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Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate

Popular Abstract in Swedish Stamcellsbiologi är ett vetenskapligt, kliniskt och politiskt aktuellt ämne idag. Nuförtiden används blodstamceller för att behandla patienter med blod-cancer, bröstcancer eller andra immun-försvarssjukdomar. Blodstamceller finns i benmärgen och är viktiga för blodbild-ning som pågår kontinuerligt genom hela livet hos en individ. Det finns olika slags mogna celler: rödaHematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. HSCs are enriched in lineage n

Great Britain, the United States, and the Security of the Middle East: The Formation of the Baghdad Pact

Popular Abstract in Swedish Anglo-amerikanska relationer efter andra världskriget bestod både av samarbete och konflikt. Ett exempel på det första var Pentagondiskussionerna 1947 då ett amerikanskt uttalande betonade det generella målet att upprätthålla säkerheten i Mellanöstern genom att stödja de brittiska politiska, ekonomiska och strategiska positionerna i området. Ett exempel på det senare vaAnglo-American post-Second World War relations in the Middle East included cases of close cooperation and conflict. An example of the former was the Pentagon Talks in 1947 when an American statement pointed out the general objective of maintaining the security of the Middle East by retaining the British political, economic, and strategic position in areas supported by the United States. An example

Ny avhandling - ägglavar i västra Nordamerika.

För den som vill ha något att bita finns det många angelägna projekt inom lavsystematiken. Ett släkte som inte har rönt någon större uppmärksamhet de senaste 50 åren är Candelariella, ägglavarna, med sin svårbegripliga arttaxonomi. Nu finns en avhandling som förhoppningsvis kan kasta lite ljus på systematiken inom detta släkte. Martin Westberg, en av våra redaktörer, är författare till denna och s

Short-term outcome after laparoscopic and open 360 degrees fundoplication - A prospective randomized clinical trial

Background: Despite the lack of randomized trials supporting the laparoscopic approach, laparoscopic antireflux surgery has gained widespread acceptance during the last decade. The aim of this study was to compare the short-term symptomatic and objective outcome after laparoscopic and open 360 degrees fundoplication in a prospective randomized clinical trial. Methods: Sixty patients with GERD were

Inferior vestibular neuritis

Sudden, spontaneous, unilateral loss of vestibular function without simultaneous hearing loss or brain stem signs is generally attributed to a viral infection involving the vestibular nerve and is called acute vestibular neuritis. The clinical hallmarks of acute vestibular neuritis are vertigo, spontaneous nystagmus, and unilateral loss of lateral semicircular function as shown by impulsive and ca

Normalization of array-CGH data: influence of copy number imbalances

BACKGROUND: High-resolution microarray-based comparative genomic hybridization (CGH) techniques have successfully been applied to study copy number imbalances in a number of settings such as the analysis of cancer genomes. For normalization of array-CGH data, methods initially developed for gene expression microarray analysis have, in general, been directly adopted and used. However, these methods

Byggteknikhistoria - några iakttagelser

Genom ett antal artskilda exempel - valda fran det byggnadstekniska området i vid mening - har vi nu försökt belysa några karakteristiska fenomen inom teknikhistorien. Från den inledande beskrivningen av geodesins utveckling har vi kunnat observera den växling, som skett historiskt av denna vetenskaps referensram. I den tidiga historien gav därvid studier av fenomen på jorden underlaget för uppfat

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-)

The Preboreal climate reversal and a subsequent solar-forced climate shift

Accurate chronologies are essential for linking palaeoclimate archives. Carbon-14 wiggle-match dating was used to produce an accurate chronology for part of an early Holocene peat sequence from the Borchert (The Netherlands). Following the Younger Dryas-Preboreal transition, two climatic shifts could be inferred. Around 11 400 cal. yr BP the expansion of birch (Betula) forest was interrupted by a

Barriers to effective implementation of guideline recommendations.

Cardiovascular disease (CVD) is the leading cause of death worldwide, and its prevention and treatment are important healthcare aims. Hypercholesterolemia is among the most important modifiable Rick factors for CVD, and numerous guidelines exist for the treatment of this condition. Nevertheless, despite the existence of well-established and safe pharmacologic therapy for lowering cholesterol and p

Hushållens energianvändning och styrmedelsstrategier

Under decennier har alla samhällssektorer blivit alltmera beroende av tillgång till säkra energileveranser för att kunna utföra sina uppdrag vare sig det gäller företag eller offentlig service och verksamhet. Även hushåll har för sitt vardagsliv blivit beroende av energi för att hålla värme i bostaden, laga mat, tvätt och hygien samt för att orientera sig i omvärlden via radio, TV eller internet.

Ground state and electronic spectrum of Cu(II) and Cu(III) complexes of N,N '-1,2-phenylenebis-2-mercaptoacetamide

The electronic structure and the UV- vis spectrum of reduced and oxidized model systems of the N, N'- 1,2phenylenebis( 2- mercapto- 2- methylpropionamide) copper complex have been studied using a multiconfigurational quantum chemical method ( CASSCF/ CASPT2). The bonds between Cu and the two sulfur ligand atoms have a large covalent character in the oxidized Cu( (III)) form. As a result of the inc

High-repetition-rate, hard x-ray radiation from a laser-produced plasma: Photon yield and application considerations

We present an experimental study of hard x rays produced in laser-produced plasmas. The laser used is a 1 kHz system, delivering 0.7 mJ for 25 fs onto a solid target. The x-ray spectrum was measured with calibrated germanium detectors, allowing a very good estimate of the absolute number of photons emitted from the plasma over a wide energy range; from 7 keV to 0.5 MeV. Assuming a bi-Maxwellian el

Statistical presentation and analysis of ordinal data in nursing research.

Objectives: The aim of this study was to review the presentation and analysis of ordinal data in three international nursing journals in 2003. Method: In total, 166 full-length articles from the 2003 editions of Cancer Nursing, Scandinavian Journal of Caring Sciences and Nursing Research were reviewed for their use of ordinal data. Results: This review showed that ordinal scales were used in abo