Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with squamous cell carcinomas (SCCs). Furthermore, there are reports of KAs that have metastasized, invoking the question of whether KA is a variant of SCC (Hodak et al., 1993). To date, no reported criteria are sensitive enough to discriminate reliably between KA and SCC, and

Acute tubular necrosis (ATN), elicited by ischemia and/or toxicity, is a potentially life-threatening condition. Histologically, ATN corresponds to necrosis and detachment of renal tubular epithelial cells. However, the tubules possess a considerable regenerative capacity and may be restored. We have previously identified a scattered population of progenitor-like cells within the proximal tubules,

A combination of synchrotron radiation photoelectron spectroscopy and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy has been used to study the adsorption of phenylphosphonic acid (PPA) on anatase TiO2(101) single crystal at coverages of 0.15 monolayer (ML) and 0.85 ML. The photoelectron spectroscopy data suggest that at 0.15 ML coverage PPA adsorbs in a bidentate geometry followi

The soot growth region of a premixed one-dimensional ethylene/air flame has been investigated using two-color laser-induced incandescence (2C-LII) with focus on optical soot properties. From the 2C-LII technique, primary soot particle sizes were deduced together with the temperature from pyrometry of the laser-heated particles, while the gas temperatures were obtained from pure rotational CARS nit

Over the last years, an expanding family of small regulatory RNAs (e.g. microRNAs, siRNAs and piRNAs) was recognized as key players in novel forms of post-transcriptional gene regulation in most eukaryotes. However, the machinery associated with Ago/Dicer-dependent small RNA biogenesis was thought to be either entirely lost or extensively simplified in some unicellular organisms including Trypanos

Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the

In spite of recommendations advocating conservative best medical treatment, many patients with infrainguinal intermittent claudication (IC) are treated by invasive open and endovascular methods. This study aims to evaluate the incidence and 1-year results of all such treatments during 2009 in Sweden.

Studying information flow between node clusters can be conceptualised as an important challenge for the knowledge management research and practice community. We are confronted with issues related to establishing links between nodes and/or clusters during the process of information flow and search transfer in large distributed networks. In the case of missing socio-technical links, social networks

Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations

The electronic structure of cobalt phthalocyanine (CoPc) on Pt(111), graphene/Pt(111), and Au-intercalated graphene/Ni(111) is investigated by photoexcited electron spectroscopies: photoemission (XPS and UPS) and X-ray absorption spectroscopy (XAS or NEXAFS). For CoPc on Pt(111), significant changes of the shape of XPS and XAS spectra indicate a charge transfer from the metal substrate to the Co i

Background: This study investigated the clinical importance of linked angiogenetic biomarkers to chemotherapy, combined with the anti-vascular endothelial growth factor A (anti-VEGF-A), as a first-line treatment in patients with metastatic colorectal cancer (mCRC). Methods: A total of 230 patients from a randomised phase III study were included. The primary microRNA-126 (pri-miRNA-126) A24G single

Overfishing and eutrophication affects coastal communities worldwide, leading to dwindling fish stocks and deteriorated habitats. Hence, attempts to rebuild overfished stocks to past fish productivities need to account for functional relations between habitat types and fish performance. Here we quantify resource availability, foraging performance and anti-predator behaviour of juvenile Atlantic co

Background: Abdominal adhesions develop on da- maged peritoneal surfaces and constitute a significant health related problem. Previous animal studies have shown promising anti-adhesive effects when adminis- tering the polycation α-poly-L-lysine (αPL) and the polyanion poly-L-glutamate (PG) together. The ob- jective of the study was to examine the effect of these differently charged polypeptides wh

Transgenerational effects of environmental conditions can have several important ecological and evolutionary implications. We conducted a fully factorial experiment manipulating food availability across three generations in the collembolan Folsomia candida, a springtail species that inhabits soil and leaf litter environments which vary in resource availability. Maternal and grandmaternal food avai

The crucial step in the conversion of solar to chemical energy in photosynthesis takes place in the reaction centre, where the absorbed excitation energy is converted into a stable charge-separated state by ultrafast electron transfer events. However, the fundamental mechanism responsible for the near-unity quantum efficiency of this process is unknown. Here we elucidate the role of coherence in d

Palladium complexes containing abnormally bound C4-bound dicarbene ligands have been exploited for catalytic alkene hydrogenation. Comparison to normally C2-bound homologues indicates that the carbene bonding mode critically influences the catalytic activity. Good catalytic performance in the hydrogenation of cis-disubstituted olefins and non-isomerizable terminal olefins under mild conditions (RT

Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age

Lasers are common tools in the field of combustion diagnostics In some respects, however, they have disadvantages Therefore, there is a need for new light sources delivering radiation in the required wavelength regions with high stability and reliability at low cost Light-emitting diodes (LED) in the near and mid infrared spectral region have proven their potential for spectroscopic applications i

Patients with haemophilia A and inhibitors are at high risk for severe bleeding, progression of joint disease and deterioration of health-related quality of life (HRQoL). To determine the impact of prophylaxis with an activated prothrombin complex concentrate (aPCC) on HRQoL, HRQoL was assessed using the Short-Form (SF)-36 Health Survey and the EQ-5D questionnaire in subjects 14years participating