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När vi pratar om mobilitet tänker många på bussar, tåg och bilar. Men på landsbygden handlar mobilitet om något större: tillgång till livet. Dagens sätt att mäta transporter är utformat för städer och fokuserar på kostnad per passagerare och restid. Dessa mått fungerar dåligt i glesbygd, där avstånd inte är ett val utan en geografisk realitet. Människor kör bil ofta för att det helt enkelt saknas
Triple-negative breast cancer (TNBC) exhibits heterogeneous treatment responses, yet molecular subtypes based on predefined biological pathways show limited prognostic value. We introduce tumor-specific total mRNA expression (TmS), a pathway-agnostic deconvolution metric derived from matched RNA/DNA sequencing, as a robust stratification tool. Analyzing 575 TNBC patients across Western and East As
Group A Streptococcus (GAS) forms highly deformable aggregates with broad variations in size and morphology, complicating controlled separation and biological analysis. Reliable methods to isolate fractions of GAS clusters with defined properties are essential for studying host–pathogen interactions that depend on cluster size. Here, we present a simple deterministic lateral displacement (DLD) mic
The purpose of this pilot study was to develop and characterize an in vivo porcine model of hyperoxaluria using intravenous infusion of sodium oxalate (NaOx). Two experimental regimens were developed to replicate acute and follow up chronic hyperoxaluria. In the acute model, 3 different doses of 1% NaOx were administered over 15 h, resulting in a dose-dependent increase in plasma oxalate concentra
Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). To improve treatment guidance, biomarkers are needed. We use whole-genomics (WGS; n = 155) with matching whole-transcriptomics (WTS; n = 113) from biopsies of ARSI-treated mCRPC patients for unbiased discovery of biomarkers and development of machine learning-based pr
PURPOSE: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using large cohorts. Thus, we sought to identify the intrinsic molecular subtypes of mCRPC and assess molecular and clinical correlates in the largest combined cohort
Background and purpose —The use of a tourniquet in knee replacement surgery is debated. Given the conflicting evidence, we aimed to compare the risk of revision after total knee replacements (TKR) with or without the use of tourniquet. Methods — In this register based observational study, we included the 5 most common cemented primary TKR models due to osteoarthritis reported to the Swedish Arthro
We report the inverse association between the expression of androgen receptor (AR) and interleukin-1beta (IL-1β) in a cohort of patients with metastatic castration resistant prostate cancer (mCRPC). We also discovered that AR represses the IL-1β gene by binding an androgen response element (ARE) half-site located within the promoter, which explains the IL-1β expression in AR-negative (ARNEG) cance
How do new companies attempt to captivate customers in a food market they are substantially seeking to transform? Plant-based meat has been marketed as a revolutionary food product that will not only transform markets but also provide better health and reduced environmental harms. Building on conceptualizations of captivation, we analyze video ads from leading brands. Our results highlight four mo
DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can "phenocopy" pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients to benefit from targeted treatments. We hypothesized that RNA phenocopy signatures of key cancer driver gene m
To meet future demands for cleaner water and comply with the revised Urban Wastewater Treatment Directive (UWWTD), many European wastewater treatment plants (WWTPs) will need quaternary treatment to reduce emissions of organic micropollutants (OMPs). Quaternary treatment based on granular activated carbon (GAC) is a promising solution, yet long-term, full-scale operational data remain scarce. This
Purpose To investigate patient-reported symptom relief day-by-day and the use of postoperative analgesics after open trigger finger release. The primary outcome of this study was the number of days to resolution of pain. Secondary outcomes were the use of analgesics and the number of days to complete resolution of stiffness and triggering. Methods In this prospective, multicenter cohort study, a t
We develop a Lyapunov-based analysis of Korpelevich’s extragradient method and show that it achieves an o(1/k) last-iterate convergence rate of the constructed Lyapunov function. This Lyapunov function simultaneously upper bounds several standard measures of optimality, which allows our analysis to sharpen existing last-iterate convergence guarantees for these measures. Moreover, the same analysis
Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with divers
Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com
The downscaling of environmental responsibilities poses new challenges for regional governments, necessitating an evolution in their roles to manage environmental policy alongside traditional local development duties. This paper draws on the concept of the entrepreneurial state and on the idea of the ‘entrepreneurial region’ to explore how local and regional governments implement bioeconomy polici
