With scanning ion conductance microscopy (SICM), a noncontact scanning probe technique, it is possible both to obtain information about the surface topography of live cells and to apply molecules onto specific nanoscale structures. The technique is therefore widely used to apply chemical compounds and to study the properties of molecules on the surfaces of various cell types. The heart muscle cell

OBJECTIVE: To increase the understanding of how definitions of standards for housing design influence the proportion of dwellings not meeting the standards and the proportion of individuals defined as having accessibility problems. METHODS: The sample included old people and their dwellings in three European countries (N = 1,150). Frequencies and percentages were reported and empirical distributio

Early to late Holocene sediments from core F80, Fårö Deep, Baltic Sea, are investigated for their palynomorph composition and dinoflagellate cyst record to map variations in sea-surface-water salinity and palaeoproductivity during the past 6000 years. The F80 palynomorph assemblages are subdivided into four Assemblage Zones (AZs) named A to D. The transition from the stratigraphically oldest AZ A

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 i

A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one d

The pressure distribution over a compressed breast is in general heterogeneous. In this study we investigated the pressure distribution over compressed breasts with tumor masses. Twenty-two women either recalled for work-up of findings suspicious for breast cancer in the screening program or with clinically suspected findings were included in the study. Twenty-one lesions turned out to be malignan

A density functional theory study is presented regarding the energetics and the Mulliken population analyses of a quantum mechanical/molecular mechanical (QM/MM) system including multiple iron-sulfur clusters in the QM region. The [FeFe]-hydrogenase from Desulfovibrio desulfuricans was studied, and both the active site (an Fe6S6 assembly generally referred to as the H-cluster) and an ancillary Fe4

1. Environmental factors fluctuate spatially and temporally, and organisms that can alter phenotype in response to these changes may increase their fitness. Zooplankton are known to be able to induce body pigmentation in response to ultraviolet radiation (UVR) and to reduce the pigmentation when exposed to fish predators. Hence, reduced pigmentation because of the presence of fish could potentiall

Online social media are a perfect text source for stance analysis. Stance in human communication is concerned with speaker attitudes, beliefs, feelings and opinions. Expressions of stance are associated with the speakers' view of what they are talking about and what is up for discussion and negotiation in the intersubjective exchange. Taking stance is thus crucial for the social construction of me

Thyroid hormone level has been positively associated with breast cancer risk and with breast cancer cell proliferation and growth. Although breast cancer is a heterogeneous disease, this is the first study assessing pre-diagnostic levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibodies (TPO-Ab) in relation to breast cancer s

P>Shigella bacteria invade macrophages and epithelial cells and following internalization lyse the phagosome and escape to the cytoplasm. Galectin-3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection. Galectins are synth

Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that results in damage to myelin sheaths and axons in the central nervous system and which preferentially affects young adults. We performed a proteomics-based biomarker discovery study in which cerebrospinal fluid (CSF) from MS and control individuals was analyzed (n=112). Ten candidate biomarkers were selected for eval

Late Ordovician shelly faunas occur at several localities in the Ostersund area of Jamtland (Sweden) and developed against a background of intense and rapid global climate change. In the eastern part, approximately in the middle parts of the Krykas Quartzite, and in the western part in the uppermost Kogsta Siltstone changes in faunas and sedimentary patterns provide regional evidence of these glob

Measurements of double-helicity asymmetries in inclusive hadron production in polarized p + p collisions are sensitive to helicity-dependent parton distribution functions, in particular, to the gluon helicity distribution, Delta g. This study focuses on the extraction of the double-helicity asymmetry in eta production ((p) over right arrow + (p) over right arrow -> eta + X), the eta cross section,

Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Adult ALL patients (median age at study 25 years), treated with 24 Gy (18-30) of CR

Objective: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing vascular diseases (VD) such as myocardial infarction, stroke and venous thrombosis, which can only partly be explained by traditional risk factors. The role of platelets in this process has not been extensively studied. Platelet activation supports complement binding to the platelet surface, and incre

Recent evidence indicates experience-dependent brain volume changes in humans, but the functional and histological nature of such changes is unknown. Here, we report that adult men performing a cognitively demanding spatial navigation task every other day over 4 months display increases in hippocampal N-acetylaspartate (NAA) as measured with magnetic resonance spectroscopy. Unlike measures of brai

The chapter explores the potentials of a new type of pedagogical agent – a Challenger Teachable Agent. The aim of such a pedagogical agent is to increase engagement and motivation, and challenge students into deeper learning and metacognitive reasoning. It is based on the successful implementation of the Learning by Teaching approach in Teacheable Agents, and in addition it draws on previous work

Climate-herbivory interactions have been largely debated vis-à-vis ecosystem carbon sequestration. However, invertebrate herbivores also modify emissions of plant biogenic volatile organic compounds (BVOCs). Over the shorter term, they do this by the induction of de novo synthesis of a plethora of compounds; but invertebrates also affect the relative proportions of constitutively BVOCs-emitting pl