OBJECTIVE: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).DESIGN: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden.METHODS: Seventy-one adult patients diagnosed with prima

Background: The preservatives methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI are well-known contact sensitizers. Recently, an increase in the contact allergy frequency for MI 0.2% aqueous (aq) has been seen in many European countries paralleled with an increase in MCI/MI allergy. Many of the MI-allergic patients do not react to MCI/MI 0.01% or 0.02% because the concentration of

Context: After an anterior cruciate ligament (ACL) injury, a majority of patients have a traumatic bone marrow lesion (BML, or bone bruise). The clinical relevance of posttraumatic lesions remains unclear. Objective: To explore the cross-sectional associations between traumatic BML volume and self-reported knee pain and symptoms among individuals within 4 weeks of ACL injury. Design: Cross-section

The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and reg

In this work we present a practical thermogravimetric method for quantifying the IEC (ion exchange capacity) decrease of hydroxide exchange membranes (HEMs) during intrinsic degradation mainly occurring through nucleophilic attack of the anion exchanging group by hydroxide ions. The method involves measuring weight changes under controlled temperature and relative humidity. These conditions are cl

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one si

We prove, when S is a 2-group of order at most 29, that each reduced fusion system over S is the fusion system of a finite simple group and is tame. It then follows that each saturated fusion system over a 2-group of order at most 29 is realizable. What is most interesting about this result is the method of proof: we show that among 2-groups with order in this range, the ones which can be Sylow 2-

The peak-to-valley method was investigated under laboratory conditions and in situ with respect to both 134Cs perturbation of the 137Cs valley and use of collimation. The 134Cs perturbation is significant down to 134Cs:137Cs activity ratios of 1:100. In these cases the full energy peaks from 134Cs (796 and 802 keV) and associated valley should be used instead of the peak and valley from the 137Cs

We present the charged-particle pseudorapidity density in Pb–Pb collisions at sNN=5.02 TeV in centrality classes measured by ALICE. The measurement covers a wide pseudorapidity range from −3.5 to 5, which is sufficient for reliable estimates of the total number of charged particles produced in the collisions. For the most central (0–5%) collisions we find 21400±1300, while for the most peripheral

In this paper, a parametric analysis on the main engine calibration parameters applied on gasoline Partially Premixed Combustion (PPC) is performed. Theoretically, the PPC concept permits to improve both the engine efficiencies and the NOx-soot trade-off simultaneously compared to the conventional diesel combustion. This work is based on the design of experiments (DoE), statistical approach, and i

Employing a socio-legal approach that draws on Bourdieuian studies of law, this study critically examines self-determination’s status as a norm of international activity by tracing the manner in which it has been articulated and transformed by a number of key actors, the empirical and theoretical tensions accompanying its trajectory, and the negotiations and interactive contestations that lie outs

Dredged material resulting from deepening and maintenance activities of the Aveiro Harbor inlet channel, northwestern coast of Portugal, has been used to mitigate the erosion trend recorded on nearby beaches (from Barra to Costa Nova Beach) through direct placement of sand by using standard dredge equipment. The disposal activities of dredged material have been undertaken at two main sites: betwee

Vacuum impregnation (VI) has been widely used as pre-treatment prior to, e.g., minimal processing, freezing, or drying of fruit and vegetables. Most of the investigations have focused on the applicability of VI to modify physicochemical, sensory, and nutritive characteristics. However, little attention has been paid to the metabolic consequences of impregnating different substances into the plant

Flexibility and modulus of elasticity data for two types of wet cellulose fibres using a direct force–displacement method by means of AFM are reported for never dried wet fibres immersed in water. The flexibilities for the bleached softwood kraft pulp (BSW) fibres are in the range of 4–38 × 1012 N−1 m−2 while the flexibilities for the thermomechanical pulp (TMP) fibres are about one order of magni