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The properties of the amyloid-beta peptide that lead to aggregation associated with Alzheimer's disease are not fully understood. This study aims at identifying conformational differences among four variants of full-length Abeta42 that are known to display very different aggregation properties. By extensive all-atom Monte Carlo simulations, we find that a variety of beta-sheet structures with dist

Drought is a recurrent natural hazard that is expected to increase in the future due to anthropogenic climate change. The Middle East region witnessed a drought period between 2007 and 2009 that has been reported to have severe consequences for the population, especially in Syria and Iraq. This study seeks to assess the spatial and temporal characteristics of the drought in the Duhok Governorate i

Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation. We studied exocytosis, measured as increase in membrane capacitance (ΔCm), as a function of calcium entry (Q) in insulin secreting INS-1 832/13 cells using patch cla

The focus of this paper is on how organizational change within medical research evolves and is influenced by different types of institutions at different geographical levels, as well as what characteristics of the key individuals are important in enacting institutional opportunities and overcoming hindrances. The paper reveals the complexity of institutions influencing change processes. First, the

We studied the commencement and finishing of the growing season using different air temperature indices, the surface albedo, the chlorophyll fluorescence (Fv/Fm) and the carbon dioxide (CO2) tropospheric concentration, together with eddy covariance measurements of CO2 flux. We used CO2 flux data from four boreal coniferous forest sites covering a wide latitudinal range, and CO2 concentration measu

Development of InN films for devices is hindered due to metallic In clusters, formed readily during growth, and unintentional n-type conductivity of the nominally undoped films, including surface electron-accumulation layers via the Fermi level pinning into the conduction band. Plasma nitridation eliminates even large In clusters from the surface by changing them to two-dimensional InN [Yamaguchi

Popular Abstract in Swedish Alla människor ska kunna vara delaktiga i samhället och mobilitet är viktigt för att kunna förflytta sig i bostaden och i samhället i stort. Mobilitet gör det möjligt att vara delaktig i olika aktiviteter som till exempel sociala aktiviteter och fritidsaktiviteter. Den åldrande befolkningen ökar och eftersom förflyttningssvårigheter ökar med stigande ålder, ökar även anThis thesis elucidates the use of powered mobility devices in a Swedish context. The overall aim was to increase and deepen the knowledge on powered mobility device use in relation to participation and accessibility in different environments and among different user groups, with a specific focus on independence and autonomy. An additional aim was to contribute to the knowledge base regarding the o

Review

Popular Abstract in Swedish I denna avhandling undersöker vi vilka anpassningar som behöver göras i designen av matematikkurser när de överförs från en kulturell miljö till en annan. Vi fokuserar på en kurs i beräkningsmatematik som undervisas på Lunds Universitet i Sverige och som vi under studien överförde till Sorans Universitet i Kurdistan/Irak. Projektet har två delar. Den första diskuterar hThis thesis aims to investigate necessary adaptations in the design of a mathematics course when it is transferred from one cultural environment to another. We focus on an elementary course in computational mathematics with Python taught at Lund University, Sweden, and at Soran University, Kurdistan/Iraq. This project holds two main parts. The first part elucidates how the necessary changes in tea

Cormac McCarthy's The Road takes place not before or during but after the end. The novel follows a man and his son as they seek to survive in what remains of the world after some unspecified cataclysmic event. There is almost nothing left: no society, no food, no animals, no hope. Many readers will feel that the question the novel poses is why anyone would wish to continue living under such circum

23 species of the lichen genus Caloplaca from Svalbard are described and/or discussed. The descriptions are natural language descriptions based on characters for each species coded into LIAS (Global Information System for Lichenized and Non-Lichenized Ascomycetes). A total of 37 Caloplaca species are listed for Svalbard, of which two species: C. elvebakkiana and C. scabrosa are described as new to

Relying on efficiency analysis, we evaluate to what extent policy makers have been able to promote the establishment of consolidated and comprehensive research groups to contribute to the implementation of a successful innovation system for the Spanish food technology sector, oriented to the production of knowledge based on an application model. Using data envelopment analysis techniques that allo

A simple and fast method is presented to be used for example in studies on the relationship between serum levels of persistent organic pollutants and type 2 diabetes mellitus. Method is based on liquid-liquid extraction and gas chromatography coupled with high.-resolution mass spectrometry. In the sample pretreatment special attention was paid to minimize the number of sample manipulation steps an

Physical properties of aqueous solutions of hydrophobically modified crosslinked polyacrylic acids change quite extensively as the polymer is charged up. A study is carried out concerning the similarities between two polymer ionization processes, that is, by pH increment and anionic surfactant addition. The two processes charge the polymer by distinctly different mechanisms. At sufficiently high p

Background: Conventional radiography is insufficient for diagnosis in a small but not unimportant number of hip fractures, and secondary imaging with computed tomography (CT) or magnetic resonance imaging (MRI) is warranted. There are no convincing observer variation studies performed for conventional radiography or CT in occult fractures, and no large materials for MRI. Purpose: To assess observe

Popular Abstract in Swedish Cerebral Pares (CP) är en övergripande benämning på ett rörelsehinder som orsakas av en skada som inträffat i en omogen hjärna. Graden av rörelsehinder varierar. Det föds cirka 200 barn årligen i Sverige med CP. Hög muskelspänning i kombination med muskelförsvagning och svårigheter att ändra ställning kan leda till att höften går ur led (höftledsluxation) och att ryggenAbstract Background: Children with cerebral palsy (CP) have an increased risk of scoliosis, contractures including windswept hip deformity (WS), and hip dislocation. In 1994, a follow-up program and registry for children and adolescents with CP (CPUP) was initiated in Sweden to allow the early detection and prevention of hip dislocations and other musculoskeletal deformities. Purpose: To analyze t

The expression of the inflammatory G-protein coupled receptor CysLT1R has been shown to be upregulated in colon cancer patients and associated with poor prognosis. The present study investigated the correlation between CysLT1R and colon cancer development in vivo using CysLT1R antagonists (ZM198,615 or Montelukast) and the nude mouse xenograft model. Two drug administration regimens were establish