BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C

Open Government Data (OGD) is an important driver for open innovation among public entities. However, extant research highlights a need for improved feedback loops, collaboration, and a more demand-driven publication of OGD. In this study, we explore how public platform providers can address this issue by enabling collaboration within OGD ecosystems, both in terms of the OGD, and any related Open

Riktlinjer för Kungl. Konsthögskolans grafiska formgivning beskrivs i skriften Mellan sköldebrev och varumärkesmanual. Skriften är främst riktad till dig som arbetar med högskolans grafiska formgivning och kommunikation, men även till dig som har annan anknytning till verksamheten eller är intresserad av konstnärliga högskolors kommunikation med omvärlden.

This paper describes and discusses the development of mobile exergames for children with cerebral palsy. The design process was built on co-design, and resulted in three activity games, two augmented reality (AR) games and one GPS based game. The resulting activity games were evaluated by 8 per-sons with cerebral palsy (CP). To complement this evaluation, the games have been evaluated against exis

I denna bok beskrivs och analyseras unga mäns berättelser om utsatthet för misshandel, rån och hot. Boken syftar till att visa på komplexiteten i ämnen som brott, offerskap och etnicitet. Ungdomar med svensk respektive invandrarbakgrund beskriver ofta varandra utifrån ett ”vi” och ett ”dom”. I mediaskildringar har denna dikotomi förstärkts vad gäller brottslighet och offererfarenhet. Men hur beskr

The aim of this theoretical paper is to critically reflect on the ethical and methodological issues that arose during a study that observed nurses’ care-giving in an intensive care unit setting. The authors critically discuss the methodological and ethical issues as well as the practical realities that were encountered when evaluating a complex intervention using unstructured qualitative observati

Although remarkable progress has been achieved in reducing hunger and poverty and improving people’s health in the past couple of decades, humanity still faces considerable socio-economic and sustainability challenges. Ensuring sustainable access to safe and sufficient water, improved sanitation facilities, clean energy sources and healthy food is a necessary requirement for ending hunger and pove

Background: The five Nordic Associations for palliative medicine (PM) have since 2003 organized a common specialist course for six weeks in two years. Aim: To describe the course: participants, evaluations, impact on participants' careers, and on the development of PM in the Nordic countries. Methods: Information on participants taken from the course archive and national registries. A web survey s

The biological function of a protein is intimately related to its structure and dynamics, which in turn are determined by the way in which it has been folded. In vitro refolding is commonly used for the recovery of recombinant proteins that are expressed in the form of inclusion bodies and is of central interest in terms of the folding pathways that occur in vivo. Here, biophysical data are report

Aims: Obesity is a risk factor for several cardiovascular diseases (CVDs), including atrial fibrillation (AF). However, it is less clear whether overall fat or abdominal fat distribution are most important for risk of developing AF. This study investigates how different anthropometric measures correlate to the risk of developing clinical AF in the Malmö Diet and Cancer cohort (MDC-cohort). Methods

Spectroscopy from the final internal data release of the Gaia-ESO Survey (GES) has been combined with Gaia EDR3 to assign membership probabilities to targets observed towards 63 Galactic open clusters and 7 globular clusters. The membership probabilities are based chiefly on maxim likelihood modelling of the 3D kinematics of the targets, separating them into cluster and field populations. From 43

Penetration of the viral genome into a host cell nucleus is critical for initiation of viral replication for most DNA viruses and a few RNA viruses. For herpesviruses, viral DNA ejection into a nucleus occurs when the capsid docks at the nuclear pore complex (NPC) basket with the correct orientation of the unique capsid portal vertex. It has been shown that capsid vertex-specific component (CVSC)

Some first investigations have focused on the consequences of the COVID-19 pandemic for the general mental health after its outbreak in 2020. According to multiple self-reporting surveys, symptoms of stress, anxiety, and depression have risen worldwide. Even some studies based on health care records start to be published, providing more objective and statistically reliable results. Additionally, c

How might the connections between anthropology and international law become more dynamic? I reflect upon this question in this essay using ethnographic insights from the documentary cycles of the UN Human Rights Committee, the treaty body monitoring state compliance with the International Covenant on Civil and Political Rights. Building on recent anthropological scholarship on international organi

Should anthropologists continue to use pseudonyms in their writings? I joined this symposium thinking that the answer would be “no.” Yet through the writing of this essay my view changed. In what follows, I share this shift of view with insights from my research among human rights experts at the UN and NGOs, and state delegates in the Finnish Ministry of Foreign Affairs (Halme-Tuomisaari 2017, 201

CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signa