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Target cell entry of HIV-1 is dependent on the binding of gp120, the outer component of the viral envelope glycoprotein complex (Env), to CD4 and a coreceptor, preferentially CCR5 or CXCR4. Still, other interactions may also contribute to the infectivity of the virus. One such interaction is between the highly glycosylated gp120 and carbohydrate-binding proteins, such as galectins. Here, we studie
Purpose: Radiotherapy (RT) for patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) can be intensified by delivering 6 (6fx/w) instead of 5 (5fx/w) fractions per week. Randomized trials have demonstrated superiority for 6fx/w in patients treated without concurrent chemotherapy (CRT). This real-world analysis compares 6 vs 5 fx/w in LA-HNSCC all-comers, treated predominan
Music generation has progressed rapidly in recent years, but practical track-to-track transitions are still largely handled with conventional signal processing such as equal-power crossfades and manual beatmatching. This thesis evaluates whether latent-space interpolation in a pretrained neural audio codec can serve as a short, targeted generation operator for music transitions, where the goal is
One of the most prevailing ideas within contemporary philosophy of language is Representationalism: the idea that there is a word-world relation which plays a key role for explaining how language works. This relation is usually invoked both to explain what our utterances are about – what names and noun-phrases refer to – and what our utterances mean – how they represent the world as being. The top
Introduction: Out-of-pocket (OOP) healthcare costs remain prohibitive in low-resource settings, often pushing families into poverty. Universal health coverage (UHC) goals emphasise protecting households from financial hardship due to medical expenses. Objectives: This study examines which socioeconomic and demographic factors predict the amount of free mental healthcare support received by applica
Purpose This study aimed to evaluate the outcome of argon laser therapy for nonresolving central serous chorioretinopathy (CSCR) in a Saudi patient population. Patients and methods This is a prospective case series study of 20 eyes (20 patients) having nonresolving CSCR. In all of them, no signs of spontaneous improvement were noticed in 3 months. The assessment of the patients, including history
Motivated by the well established idea that collective wisdom is greater than that of an individual, we propose a novel learning dynamics as a sort of companion to the Abelson model of opinion dynamics. Agents are assumed to make independent guesses about the true state of the world after which they engage in opinion exchange leading to consensus. We investigate the problem of finding the optimal
Introduction This study aimed to evaluate the clinical impact of implementing routine emergency computed tomography (eCT) for all patients presenting with suspected acute renal colic at the emergency department (ED). Material and methods We did a retrospective observational study of all patients who underwent eCT for suspected acute renal colic at the ED in Helsingborg between May 9, 2023 and May
Carefully selecting the source data is crucial to achieve high performance of transfer learning methods for brain–computer interfaces (BCIs). Especially so in settings where a large amount of source data is available, and finding the optimal source is not computationally feasible. This paper presents a novel method for source selection, the so-called Transfer Performance Predictor (TPP) method. Th
Sedan RUT-avdraget infördes 2007 har sektorn för hushållsnära tjänster expanderat, och personer över 65 år utgör idag en av de största användargrupperna (Riksrevisionen 2020:34). Ett växande antal företag erbjuder tjänster som riktar sig till äldre och deras anhöriga. Utifrån intervjuer med RUT-företag, arbetsgivarorganisationer och fackförbund är syftet med artikeln att analysera omsorgstjänstern
Objective: Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is rel-atively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial highrisk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding the disease.Method: Twenty-eight daughters of mothers w
Background: Obesity and type 2 diabetes (T2DM) are considered risk factors for complications following total hip arthroplasty (THA). How these risk factors separately or in combination influence the risk of reoperation due to periprosthetic joint infection (PJI) or all-cause reoperation is not fully known. We sought to investigate the 2-year risk of reoperation following THA due to osteoarthritis
Since the introduction of the RUT tax deduction in 2007, the market for private domestic care services has grown rapidly in Sweden. Today, deductions can be made for cleaning and gardening, as well as for care services such as going for walks, providing companionship, assisting with dressing, and helping with personal hygiene. One main group that make use of the tax deduction are elderly over the
This special issue aims to deepen the understanding of the Europeanisation of universities from 1980 to the mid-1990s. By focussing on five universities situated in different European contexts, we aim to provide insight into how Europeanisation has taken place and changed higher education. The geographical diversity and the main differences between universities provide the opportunity to show both
Hydroxyl radicals (HO•), produced through reactions between H2O2 and iron oxides, drive biogeochemical transformations, mediate organism toxicity, and facilitate advanced oxidation processes. The effectiveness of these processes depends on the spatial proximity between HO• generation and target substrates. Consequently, the oxidation mechanisms should be governed by interfacial interactions among
