Objective. The aim of the study was to determine the effect of -ketoglutarate on the blood lipid profile using a rat animal model with experimentally induced hypercholesterolaemia. Material and methods. The female and male (30/30) Wistar rats had ad libitum access to a diet containing cholesterol (1 %) and lard (10 %) throughout the entire experimental period (120 days). On day 60 of the study, bo

The ongoing and planned experimental activities with direct reference to light unflavoured pseudoscalar mesons motivate a new theoretical study regarding their properties. An overview including details on new precise calculations is presented.

Psychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington's disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism, has been suggested. A direct link between the expression

This is a study about fairly ordinary situations in elder care: how staff deal with older people’s influence, how staff talk about older people’s complaints, how family members talk about elder mistreatment, and how older people act in order to exert influence in a nursing home. However ordinary, these are situations where relational power is accentuated, accomplished and able to be empirically ex

Therapeutic vaccination targeting self-molecules is an attractive alternative to monoclonal antibody-based therapies for cancer and various inflammatory diseases. However, development of cancer vaccines targeting self-molecules has proven difficult. One complicating factor is that tumor cells have developed strategies to escape recognition by the immune system. Antigens specifically expressed by t

OBJECTIVE-A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity. RESEARCH DESIGN AND METHODS-Variant

In this article an operator theoretic interpretation of the generalized Titchmarsh-Weyl coefficient for the Hydrogen atom differential expression is given. As a consequence we obtain a new expansion theorem in terms of singular generalized eigenfunctions.

Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune response. C. albicans controls and evades host complement attack by binding several human complement regulators like Factor H, Factor H-like protei

The aim of this study was to develop (68)Ga-SPIONs for use as a single contrast agent for dynamic, quantitative and high resolution PET/MR imaging of Sentinel Lymph Node (SLN). In addition (68)Ga enables Cherenkov light emission which can be used for optical guidance during resection of SLN. SPIONs were labeled with (68)Ga in ammonium acetate buffer, pH 5.5. The labeling yield and stability in hum

Kanon och kulturarv har diskuterats intensivt de senaste åren i Danmark och Sverige. I Danmark har regeringens beslut att definiera en dansk kanon väckt stor debatt. I Sverige har diskussionen varit hovsammare samtidigt som ordet kulturarv har ett starkt grepp om museer, kulturmiljövård och arkiv. I Danmark har diskussionen kretsat kring vad som är danskt, vem som ska definiera danskheten och vil

Background. Studies suggest an increased risk for compromised cognitive function among cancer survivors. It is unclear to what extent chemotherapy is the cause and how the dysfunction, when present, affects everyday life. The objective was to study self-reported behaviours that may depend on cognitive function, among testicular-cancer survivors who received various cycles of cisplatin-based chemot

While the conceptual history of the sign, as recounted by John Deely in Four ages of understanding, is immensely enlightening, history is never enough. If, before Augustine, it had occurred to no one that such diverse phenomena as are covered by this term had something in common, and if, in the time of Aquinas, Fonseca, and Poinsot, different usages of the term were in competition, the reason is n

In high energy collisions saturation and multiple collisions are most easily accounted for in transverse coordinate space, while analyses in momentum space have been more suitable for calculating properties of exclusive final states. In this paper I describe an extension of Mueller's dipole cascade model, which attempts to combine the good features of both these descriptions. Besides saturation it

The flow fields and heat transfer characteristics in a parallel-plate channel with a transversely placed spiral coil insert were investigated by three-dimensional numerical simulation. The structure of multi-longitudinal-vortices (MLVs) induced by the spiral coil and the effects of MLVs on velocity and temperature fields were studied. The three-dimensional spiral coil induces a series of longitudi