On molecular butterflies and eagles: improved synthesis of 5,11-R2dxCOTs
Enantioselective synthesis is an important research topic with applications in drug development. Asymmetrical catalysis is one of the available ways of producing enantioenriched products. C2-Symmetric dibenzo[a,e]cyclooctenes or dbCOTs are a family of versatile chiral ligands for transition metals. They display great efficiency and enantioselectivity in 1,2- and 1,4- additions reactions. In this