The enzymes of the polyamine-biosynthesis pathway have been proposed to be promising drug targets in the treatment of malaria. Spermidine synthase (SpdS; putrescine aminopropyltransferase) catalyzes the transfer of the aminopropyl moiety from decarboxylated S-adenosylmethionine to putrescine, leading to the formation of spermidine and 5'-methylthioadenosine (MTA). In this work, X-ray crystallograp

A ternary Mg2NiH4 hydride was synthesized using method that relies on a relatively short mechanical milling time (one hour) of a 2:1 MgH2-Ni powder mixture followed by sintering at a sufficiently high hydrogen pressure (>85 bar) and temperature (>400 degrees C). The ternary hydride forms in less than 2.5 h (including the milling time) with a yield of similar to 90% as a mixture of two polymorphic

Abstract is not available

Background: Three different classification systems for the evaluation of Barrett's esophagus (BE) using magnification endoscopy (ME) and narrow-band imaging (NBI) have been proposed. Until now, no comparative and external evaluation of these systems in a clinical-like situation has been performed. Objective: To compare and validate these 3 classification systems. Design: Prospective validation stu

Irrigation water is an important vehicle for dissemination of human pathogens to plants. As contamination in an early stage of the production chain cannot necessarily be counteracted later, cultural measures to reduce the contamination risk need to be adopted during primary production. In a two-factorial greenhouse experiment, we studied the impact of inoculum density and the interval between irri

Structured Abstract: Purpose of this paper Logisticians propose changes to improve supply chains, and legal practitioners do likewise, but from a different perspective. Proposals from one domain increasingly have an impact on the other due to e.g. globalization – but cross-disciplinary knowledge often seems limited. Our purpose is to facilitate interaction between the domains by increasing the le

Climate change is expected to generate higher short-term precipitation intensities, which may have negative consequences in terms of, for example, increased risk of flooding and sewer overflow. In this study, extreme precipitation for durations between 30 min and 1 day in simulations with the RCA3 regional climate model (RCM) for Sweden are analysed. As compared with daily observations in the peri

A novel method for lactose determination in milk is proposed. It is based on oxidation of lactose by cellobiose dehydrogenase (CDH) from the basidiomycete Phanerochaete chrysosporium, immobilised in an enzyme reactor. The reactor was prepared by cross-linking CDH onto aminopropyl-silanised controlled pore glass (CPG) beads using glutaraldehyde. The combined biosensor worked in flow injection analy

The title compound, C13H16O2, is a chiral bicyclic structure composed of two fused cyclohexane rings possessing both boat and chair conformations. The molecules are packed in enantiopure columns which are pairwise linked forming an overall racemic solid; within the column pairs the packing is governed by weak dipole-dipole interactions stemming from stacked carbonyl functionalities (COcentroid-COc

Recovery of lost neurological function after stroke is limited and dependent on multiple mechanisms including inflammatory processes. Selective pharmacological modulation of inflammation might be a promising approach to improve stroke outcome. Methods: We used 1,1'-[1,4-phenylenebis(methylene)] bis[1,4,8,11-tetraazacyclotetradecane] (AMD3100), an antagonist to the C-X-C chemokine receptor type 4 (

The author proves a very good knowledge of the most subtle and diverse narrative methods up to the point of suspecting him of affectedness in writing: he seems to enjoy drawing up the most fanciful frameworks of a novel’s design. Each new fragment is being narrated from a certain character’s point of view, the abundant prospects achieving the equivocation of the whole story up to the absurd. Some

Terrestrial ecosystem models (TEMs) contain the coupling of many biogeochemical processes with a large number of parameters involved. In many cases those parameters are highly uncertain. In order to reduce those uncertainties, parameter estimation methods can be applied, which allow the model to be constrained against observations. We compare the performance and results of two such parameter estim

We show that polarized few-electron concentric double quantum rings display localized states that are the quantum analog of classical equilibrium ones. These states have very similar energies but fairly different angular momenta, constituting a new physical realization of the isomeric states found in nuclear and molecular physics. Their fingerprint is a very soft mode in the infrared-absorption sp

Artikel om varför AT borde skrotas.An article on why the mandatory medical training after medical education should be scraped.

Popular Abstract in Swedish Vid genterapi för man in nya gener i en individs celler. Detta kan göras med hjälp av modifierade virus. Dessa virus kan föra in den nya genen, den såkallade transgenen, in i värdcellen men inte bilda nya viruspartiklar. I många fall är det viktigt att begränsa i vilka celler som transgenen uttrycks, då det producerade proteinet kan ge bieffekter i andra celltyper. Det Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects

Context. Understanding the history and the evolution of the Milky Way is one of the main goals of modern astrophysics. In particular, the formation of the Galactic disc is a key problem of Galactic archaeology. Aims. We study the velocity dispersion behaviour of Galactic disc stars as a function of the [Mg/Fe] ratio, which for small metallicity bins can be used as a proxy of relative age. This key