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Patients with hemophilia have an impaired thrombin Generation and therefore form loose fibrin hemostatic plugs that are easily dissolved by fibrinolysis. This prevents maintained hemostasis in these patients, resulting in a severe bleeding disorder. Recombinant (F)VIIa has been shown to enhance thrombin generation on already thrombin-activated platelets in the absence of FVIII and FIX. An efficacy
The southern slopes of the mountain ridge Kolmarden along the northern border of the province Ostergotland ill south-eastern Sweden have a very rich flora and varied geomorphology. Several rare and locally endemic microspecies of Hieracium have been described or reported from the area but no hieraciologist has visited the region since c. 1930. In 2004, the present author walked c. 50 km in this ar
A new electrochemical reactor, three-phase three-dimensional electrode reactor, was designed and used to investigate the removal of formic acid from simulated wastewater. The experimental results were assessed in term of Chemical Oxygen Demand (COD) removal efficiency. The results showed that the three-phase three-dimensional electrodes could effectively remove formic acid. Its COD removal efficie
Continuing our work toward a system mimicking the electron-transfer steps from manganese to P680+ in photosystem II (PS II), we report a series of ruthenium(II)-manganese(II) complexes that display intramolecular electron transfer from manganese(II) to photooxidized ruthenium(III). The electron-transfer rate constant (kET) values span a large range, 1 × 105-2 × 107 s-1, and we have investigated di
Habituation signifies a decreased response to a constant or repeated stimulus or environment. Although habituation is a fundamental form of nonassociative learning, little is known about its ontogenesis. Here, locomotor activity of postnatal ferrets within individual open field sessions was quantitatively analysed. The patterns of activity revealed a gradual shift across developmental time between
The interactions between chelating agents and metal oxide particles play important roles for the distribution and availability of metal ions in aquatic environments. In this work, the adsorption of ethylenediaminetetraacetate (EDTA) onto goethite (alpha-FeOOH) was studied as a function of pH, time, and background electrolyte concentration at 25.0 degrees C, and the molecular structures of the surf
Cerebral ischaemia is associated with elevated levels of endothelin B (ETB) receptors in the ipsilateral middle cerebral artery (MCA). This up-regulation of ET receptors occurs via de novo transcription involving mitogen-activated protein kinases (MAPK). The aim of this study was to examine the effect of inhibition of the MAP kinase/ERK kinase (MEK)1/2 on ET receptor alteration, brain damage, and
High blood levels of glucocorticoids are associated with increased mortality, confusion and poor functional outcome in stroke patients. It has been proposed that inhibition of glucocorticoids in acute stroke might be beneficial, but experimental data are conflicting and no long-term follow-up study has been reported. We have studied whether pre- or postoperative administration of metyrapone, a ste
PURPOSE. This study describes the treatment in ordinary clinical practice in Spain of patients with glaucoma with a two-drug combination therapy. The authors present the treatment outcome as end-of-period intraocular pressure (IOP) and the calculated direct medical costs over a 2-year period. METHODS. Data were extracted retrospectively from patient charts recording the use of all medical resource
Uncoupling-protein 2 (UCP2) is a mitochondrial protein that appears to be involved in cellular oxidant defense and in the regulation of oncotic cell death, both of which are important features of acute pancreatitis. However, UCP2 expression in acute pancreatitis has not been previously reported. In the current experiments, pancreatic gene expression was studied by real-time reverse-transcription/p
This paper presents a suggested methodology based on virtual reality (VR) technology that enables people with cognitive disabilities to communicate their knowledge and experiences of public transport systems. The users interacted with the VR system by verbally describing their actions to the person controlling the VR system and/or pointing with a laser pointer while seated in front of three screen
A review essay of two recent publications: L. Longo and N. Skakun (eds) "The Roots of Use-Wear Analysis: Selected Papers of S.A. Semenov" and "'Prehistoric Technology' 40 Years Later: Functional Studies and the Russian Legacy". These volumes were published upon the occasion of an international congress entitled 'Prehistoric Technology' 40 Years Later: Functional Studies and the Russian Legacy. The
This study reports outcomes of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients with chronic myeloid leukemia (CML) from the European Group for Blood and Marrow Transplantation (EBMT). The median age was 50 years, and 64% were in first chronic phase (CP1), CP2 13%, accelerated phase 17%, and blast crises 6%. The median EBMT transplant sco
An arbitrary fixed convex set in ${\bf R}^2$ is considered as are two families of equally spaced parallel lines making angle $\alpha$ with each other. It is assumed that the inter-line distance in each family of parallel lines is greater than the maximum width of the convex set. A congruent copy of the convex set is placed randomly (centroid uniform in one particular parallelogram cell and orienta
Ras and Notch signaling have recently been shown to cooperate in the maintenance of neoplastic transformation. Here, we show that TGF alpha, a known activator of Ras signaling, can drive cell proliferation and at the same time induce the expression of the Notch target Hes-1 in the neuroblastoma cell line SK-N-BE(2)c. The up-regulation of Hes-1 occurred both at the transcriptional and protein level
