Popular Abstract in Swedish Svår alfa-1antitrypsinbrist (AAT-brist), s.k. PiZZ, är ett ärftligt tillstånd som har en hög förekomst i Sverige, cirka 1/1600. Bristen innebär ökad risk för utveckling av kroniskt obstruktiv lungsjukdom (KOL), speciellt hos rökare. Leversjukdom är också relativt vanlig och kan förekomma såväl i barndomen som i hög ålder. Levercirros (skrumplever) och levercancer är öveSevere alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. The aims of the studies in this thesis which bases on AATD registry are to

A search for a fermiophobic Higgs boson using diphoton events produced in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV is performed using data corresponding to an integrated luminosity of 4.9 fb(-1) collected by the ATLAS experiment at the Large Hadron Collider. A specific benchmark model is considered where all the fermion couplings to the Higgs boson are set to zero and

Background: Climate change affects human health in various ways. Health planners and policy makers are increasingly addressing potential health impacts of climate change. Ethiopia is vulnerable to these impacts. Assessing students' knowledge, understanding and perception about the health impact of climate change may promote educational endeavors to increase awareness of health impacts linked to cl

One of the most effective propane to acrylonitrile ammoxidation catalyst is comprised of the two phases M1 (orthorhombic) Mo7.5V1.5NbTeO29 and M2 (pseudo-hexagonal) Mo4V2Te2O20. Under reaction conditions, the two phases work in symbiosis with each other where M1 is the paraffin activating component and M2 is the olefin activating component. Since the catalytic improvement of either phase should re

Recent research has shown that there is a substantial skill difference in Sweden between natives and second-generation immigrants. The objective of this study is to find out whether there exists a relationship between immigrant school segregation and the individual's human capital. The variation in immigrant concentration rate between cohorts within a school generally does not affect the individua

The World Health Organization/United Nations Children's Fund Baby-Friendly Hospital Initiative: Revised, Updated, and Expanded for Integrated Care (2009) identifies the need for expanding the guidelines originally developed for maternity units to include neonatal intensive care. For this purpose, an expert group from the Nordic countries and Quebec, Canada, prepared a draft proposal, which was dis

Background: Chronic noninfectious, nonallergic rhinitis (NINAR) is a complex syndrome with a principally unknown pathophysiology. New technology has made it possible to examine differentially expressed genes and according to network theory, genes connected by their function that might have key roles in the disease. Methods: Connectivity analysis was used to identify NINAR key genes. mRNA was extra

Bog sites and wetland settlement during the Mesolithic: research from a bog in central Scania, southern Sweden The bogs Agerods Mosse and Ronneholms Mosse with their total area of 12 km(2), form a north-westerly arm of the Ringsjon Basin of central Scania, in the southernmost part of Sweden. In the 1940s and 1970s excavations of Early Mesolithic sites around and within the bog Agerods Mosse were c

The paper focuses on the location dynamics and spatial distribution of talent by workplace to provide evidence of the multiplicity of economic geographies of city regions. City regions are not just homogenous growth machines but complex urban landscapes. The economic growth and revitalisation of the city region and the rise of the knowledge economy, including the growth of advanced business servic

Purpose: The resulting plans from a new type of treatment planning system called SharePlan (TM) have been studied. This software allows for the conversion of treatment plans generated in a TomoTherapy system for helical delivery, into plans deliverable on C-arm linear accelerators (linacs), which is of particular interest for clinics with a single TomoTherapy unit. The purpose of this work was to

Several previous studies have shown that floorball belongs to a high-risk group of sports in terms of eye injuries. Protective eyewear is available, but the extent of its use and impact on eye injuries are unknown. The purpose of this study was to investigate the current incidence of eye injuries caused by floorball and to compare it with the present use of protective eyewear. Medical records were

The fauna of hoverflies in Boreal and Arctic parts of Scandinavia is still very poorly investigated. Therefore we performed an 11 year survey of the hoverfly genus Platycheirus Lepeletier & Serville, 1828 along the Caledonian mountain chain in Sweden (from Värmland northwards to the Torneträsk area). During 2003-2013 we annually performed two trips in order to survey various areas and to colle

We investigate electron-ion recombination to excited states in atomic clusters exposed to intense NIR and XUV pulses, which leads to a yet undiscovered autoionization mechanism as a consequence of multiple recombination processes.

This study investigated the role of the antimicrobial peptide cathelicidin in Escherichia coli O157:H7 infection and subsequent renal damage. Mouse and human cathelicidin, CRAMP and LL-37, respectively, killed E. coli O157:H7 in vitro. Intestines from healthy wild-type (129/SvJ) and cathelicidin-knock-out (Camp(-/-)) mice were investigated, showing that cathelicidin-deficient mice had a thinner co

The inverse of the standard estimate of covariance matrix is frequently used in the portfolio theory to estimate the optimal portfolio weights. For this problem, the distribution of the linear transformation of the inverse is needed. We obtain this distribution in the case when the sample size is smaller than the dimension, the underlying covariance matrix is singular, and the vectors of returns a

We demonstrate interstitial diffuse optical time-of-fight spectroscopy based on a single fiber for both light delivery and detection. Detector saturation due to the massive short-time reflection is avoided by ultrafast gating of a single photon avalanche diode. We show that the effects of scattering and absorption are separable and that absorption can be assessed independently of scattering. Measu