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Melanoma brain metastases (MBM) exhibit extensive intertumor and intratumor heterogeneity (ITH), driven by a complex tumor microenvironment. The aim of this study was to perform a detailed analysis of individual MBM patient tumors using a multiomics approach, integrating spatial transcriptomics with multi-region bulk exome, proteome, and transcriptome profiling for a small group of four patient sa

This thesis is focused on the investigation of the ultrafast structural response of the phase change material (PCM) Ge$_2$Sb$_2$Te$_5$ following laser excitation. Phase change materials are a group of materials capable of rapid, non-volatile, switching between an amorphous and a crystalline phase. The two phases exhibit high optical and electrical contrast, meaning the optical reflectivity and the

Biological neural network functionality depends on the vast number of connections between nodes, which can be challenging to implement artificially. One radical solution is to replace physical wiring with broadcasting of signals between the artificial neurons. We explore an implementation of this concept by light emitting/receiving III-V semiconductor nanowire neurons in a quasi-2D waveguide. They

In recent years, unbalanced diets and high consumption of processed foods have primarily contributed to the rise of diet-related diseases, such as obesity and diabetes, among others. One way to address these problems is to increase the consumption of plant-based foods rich in fibre, healthy fats, and protein. The growing interest in plant-based foods continues to rise, leading to a rapid expansion

Van der Waals heterostructures have become a rapidly growing field in condensed matter research, offering a platform to engineer novel quantum systems by stacking different two-dimensional (2D) materials. A diverse range of material combinations, including hexagonal boron nitride, transition metal dichalcogenides and graphene, with electronic properties spanning from insulating to semiconducting,

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the comparative effectiveness of monoclonal antibodies (mAbs) for preventing respiratory syncytial virus (RSV) infection in children, and to evaluate the relative rankings for benefits and harms of mAbs for preventing RSV in children.

HfO2, one of the most common materials in resistive switching devices, can stabilize in a ferroelectric orthorhombic phase, enabling two nonvolatile polarization states via oxygen displacement in the unit cell. Under certain conditions, ferroelectric and resistive switching can coexist, independently addressable, within one device. This study employs operando spectroscopic analysis to elucidate th

Polyploidization is an important driver of evolution and diversification in flowering plants. Here, we assess how repeated polyploidization may have shaped diversification of floral morphology in Lithophragma bolanderi (Saxifragaceae). This species comprises multiple cytotypes and varies geographically in its interactions with specialized pollinating moths in the genus Greya (Prodoxidae). Past stu

This chapter explores Afghanistan's relationship with international law. Post-2001 statebuilding efforts in Afghanistan involved a strong commitment to reintegrating the Afghan state into the international legal system. However, a significant gap existed between formal commitments and on-the-ground realities. This chapter examines Afghanistan's relationship with international law by focusing on fo

Miljöfrågan är högaktuell i dagens samhälle. Företagen och kommunerna tävlar om att vara mest klimatvänliga. Detta leder till en nyfikenhet kring hur byggnadsmaterial kan användas på ett mer effektivt sätt och hur de material som redans används i våra byggnader kan få ett nytt liv på bästa sätt. En stor andel av det som byggdes på 60-talet i Sverige var av tegel, därav har intresset för att kunna Environmental issues are highly topical in today´s society, with companies and municipalities competing to be the most climate friendly. This has sparked an increasing interest in how building material can be used more efficiently and how existing materials within buildings can be given a new life. A large proportion of buildings constructed in Sweden during the 1960s were made of brick, which has

This article elaborates on the embodiment of heritage via dressing practices in several rural and urban Nordic communities in the United States. Getting dressed is a shared human practice that we engage in and repeat most days, and for special occasions, traditional dress, or folk costume, comes into particular focus. I approach dressing in folk costume as a “situated embodied practice,” a mode of

This paper explores ‘utopia as method’ to envision solid waste and sewage management systems which are equitable and sustainable. Global solid waste management is largely sustained by millions of waste pickers who collect, sort and manage waste. Sanitation workers play a vital role in maintaining sewage systems. These workers are exposed to dangerous, toxic workspaces, and they often belong to mar

Background We investigate whether, in Swedish national registers, social and psychiatric outcomes for six major psychiatric and substance disorders - drug use disorder (DUD), alcohol use disorder (AUD), major depression (MD), bipolar disorder (BD), anxiety disorder (AD), and schizophrenia (SZ) - reflect the primary genetic risk for each disorder and the level of genetic heterogeneity. Methods We u

Background Access to adequate antenatal care (ANC) is crucial for improving maternal and neonatal health outcomes. Despite high national ANC coverage, Colombia still faces regional and socioeconomic disparities. This study aims to estimate geographical and intersectional inequalities in ANC coverage and evaluate the contribution of social determinants to these disparities. Methods We conducted a c

This article analyses the rapid rise of gambling addiction in Kazakhstanwithin the broader context of Central Asia’s evolving gambling economy. Drawingon ethnographic fieldwork, it shows how digital technologies, regulatory gaps, andneoliberal reforms have expanded gambling access while deepening its harms.Official statistics vastly understate the problem, while unofficial estimates suggesthundred

Introduction Sweden, as many other high-income countries, has adopted guidelines to offer induction of labour at 41+0 gestational weeks to decrease the risk for perinatal death. As more than 20% of the pregnant population reach this gestational age, and along with other contributing factors, induction rates have increased up to 30% in many countries. Both women and care providers have raised the q

The chemical structures of dissolved organic compounds in natural waters, including the degree of aromaticity, affect their physical, chemical, and biological properties and ultimately the fate of carbon in aquatic systems and during water treatment. Herein, a new fluorescence-based aromaticity index named ARIX is shown to link the composition of aquatic dissolved organic matter to its aromaticity