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Purpose: Evaluating performance of modern dose calculation algorithms in SBRT and locally advanced lung cancer radiotherapy in free breathing (FB) and deep inspiration breath hold (DIBH). Methods: For 17 patients with early stage and 17 with locally advanced lung cancer, a plan in FB and in DIBH were generated with Anisotropic Analytical Algorithm (AAA). Plans for early stage were 3D-conformal SBR

The combustibility of timber is one of the main reasons that many building regulations strictly limit the use of timber as a building material. Fire safety is an important contribution to feeling safe, and an important criterion for the choice of building materials. Historically, the combustibility aspect of wood has been a disadvantage for using timber as a construction material. The main precond

With the purpose to increase the knowledge on human behaviour when evacuating along elevated platforms, an experiment was carried out at the subway station of Skarpnäck, Stockholm, in October 2016. The overall project objective was to develop basic data for guidelines regarding fire safety design concerning evacuation along elevated platforms. The experiment was designed as a group experiment divi

A search for supersymmetric partners of gluons and quarks is presented, involving signatures with jets and either two isolated leptons (electrons or muons) with the same electric charge, or at least three isolated leptons. A data sample of proton-proton collisions at s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider between 2015 and 2018, corresponding to a total integrated

Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein translation. Isolated reports have shown that variants that create or disrupt uORFs can cause disease. Here, in a systematic genome-wide study using 15,708 whole genome sequences, we show that variants that create new upstream start codons, and variants disrupting stop sites of existing uORFs, are under strong negat

Production cross sections of muons from semi-leptonic decays of charm and beauty hadrons were measured at forward rapidity (2.5 < y < 4) in proton-proton (pp) collisions at a centre-of-mass energy s = 5.02 TeV with the ALICE detector at the CERN LHC. The results were obtained in an extended transverse momentum interval, 2 < pT< 20 GeV/c, and with an improved precision compared to previous measurem

Multi-nucleotide variants (MNVs), defined as two or more nearby variants existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, existing tools typically do not accurately classify MNVs, and understanding of their mutational origins remains limited. Here, we systematically survey MNVs in 125,748 whole exomes and 15,708 whole

How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furth

The relationship between environmental attitudes and behaviour is known to be weak, especially when these variables are measured as self-report items in surveys. In addition many environmental questions are highly polarised, making it even more problematic to use survey data to inform policy making. To better explore the attitude–behaviour gap in the context of environmental policies, along with i

This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb−1 of proton–proton collision data at a centre-of-mass energy s=13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the bb¯bb¯, bb¯W+W−, bb¯τ+τ−, W+W−W+W−, bb¯γγ and W+W−γγ final states. Results are presented

Identifying factors responsible for the emergence and evolution of social complexity is an outstanding challenge in evolutionary biology. Here we report results from a phylogenetic comparative analysis of over 1000 species of squamate reptile, nearly 100 of which exhibit facultative forms of group living, including prolonged parent–offspring associations. We show that the evolution of social group