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When applying Bayesian optimization (BO) algorithms which utilizes Gaussian processes (GP) models, several components can be adapted to suit different systems and optimization objectives. In this paper, we explore and evaluate a set of such modifications to tailor the algorithm for a high-pressure grinding rolls (HPGR) system. The system is represented by a steady-state simulator modeling the HPGR
BackgroundLarge-scale genomic rearrangements in cancer cells can lead to the creation of fusion genes which alter the expression or function of the partner genes. Some fusion genes act as tumour drivers and the use of kinase inhibitors in patients with specific fusions have led to breakthroughs in cancer therapy. The large clinical and scientific interest in fusions has led to the development of s
BACKGROUND: Artificial intelligence may improve diagnostic yield and accuracy in syncope.OBJECTIVES: The purpose of this study was to compare Generative Pretrained Transformer 4-Omni (GPT-4o) with medical professionals (MPs) in establishing syncope diagnoses and recommending interventions based on general practitioner's referral letters to a syncope-unit.METHODS: This three-phase study evaluated 5
Congenital vascular malformations, affecting 0.5% of the population, often occur in the head and neck, complicating treatment due to the critical functions in these regions. Our previous research identified distinct developmental origins for blood and lymphatic vessels in these areas, tracing them to the cardiopharyngeal mesoderm (CPM), which contributes to the development of the head, neck, and c
Chemical defences, such as the monoterpenes of conifer oleoresin, frequently occur as complex blends of many components, but the selective pressures that maintain these mixtures are not yet known. Several theories attempt to explain the existence of chemical defence mixtures in plants. However, due to limited empirical evidence, it is unclear which theories might best apply. Here, we tested the va
Based on a combination of morphometric analyses, a chloroplast DNA phylogeny, and multivariate analyses of whole genome sequence data from >300 museum samples, we discuss and evaluate the delimitation, taxonomy, and evolution of wild and escaped taxa in Mentha subgen. Mentha, focusing on the northern hemisphere. Thirteen species (Mentha aquatica, M. arvensis, M. australis, M. capensis, M. dahurica
This thesis explores index theory for linear differential operators using tools from noncommutative geometry. We study how spectral triples can accommodate elliptic and Heisenberg-elliptic higher-order differential operators in K-homology, with a specific focus on manifolds with boundary. In the case of higher-order elliptic differential operators on manifolds with smooth compact boundary, we prov
Understanding of mononuclear phagocyte (MNP) diversity in the human intestine and the alterations this compartment undergoes in inflammation remains incomplete. Here, we used single-cell RNA sequencing, cellular indexing of trancriptomes and epitopes by sequencing, flow cytometry, and imaging to explore MNP heterogeneity in human ileal and colonic laminae propriae (LPs) in health and Crohn's disea
Pituitary tumours, originating from endocrine cells of the anterior pituitary, are quite common, and in most cases well-controlled by surgery or medical treatment. However, a small subset of pituitary tumours presents with multiple local recurrences or tumour progression despite combined surgical, medical or radiotherapeutic treatment. These are known as aggressive pituitary tumours (APT); also ca
Gut-associated lymphoid tissues (GALT) represent major sites of adaptive immune priming in the intestine, yet our understanding of human GALT diversity and function remains limited. Here, we used single-cell RNA sequencing, flow cytometry, and confocal laser microscopy to map the fibroblast (FB) landscape of human GALT, including that of Peyer's patches (PP), mucosal isolated lymphoid follicles (M
High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive subtype of ovarian cancer. The combination of late-stage diagnosis and the tendency to exhibit resistance to existing treatments highlights a critical gap in effective therapeutic options. There is thus a need for novel strategies for targeting HGSOC, particularly in its advanced stages. To address this gap, we developed
INTRODUCTION: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated associations between SV2A concentrations in the brain and cerebrospinal fluid (CSF). METHODS: Twenty-one participants with early AD and 7 cognitively normal (CN) individua
The rapid growth of smart logistics, driven by IoT devices and data-intensive applications, necessitates secure, scalable, and efficient computing frameworks. As the edge-fog-cloud (EFC) paradigm supports real-time data processing, it faces significant security threats and attacks, including privacy risks, data breaches, and unauthorized access. To address these security threats and attacks, block
We report 23 lichenicolous fungi new to Sweden, among these, one is new to Europe, 21 are new to Fennoscandia, and two are newly reported for Norway. This article focuses only on mitosporic fungi. The newly reported species are Acremonium pertusariae, Cladophialophora dimorphospora, Cladosporium licheniphilum, Corynespora laevistipitata, Didymocyrtis cladoniicola, D. grumantiana, Ellisembia lichen
BACKGROUND: Changes in Ischemic White matter hyperintensities volume (WMH) on MRI over time are associated with cognitive decline. We investigated whether changes in WMH volume over time exhibit WMH-normalized volume threshold effects on declining cognitive performance and whether these effects on cognition differ between deep white matter hyperintensities (DWMH) and periventricular white matter h
To address climate change, firms are increasingly forming sustainability alliances. Pursuing sustainability via such alliances is challenging as it means working with multifaceted and not necessarily compatible goals. Moreover, it often requires collaboration among heterogeneous partners outside traditional industrial contexts as well as dealing with wicked problems. This article presents a multip
