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Integrating bioinfomatics and physiology to describe genetic affects in complez polygenic diseases Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the gene

https://www.ludc.lu.se/education-training/theses/theses-2009/hemang-parikh - 2025-11-21

Exploring the Grey Zone between Type 1 and Type 2 Diabetes T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA),

https://www.ludc.lu.se/education-training/theses/theses-2009/ekaterine-bakhtadze - 2025-11-21

Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus The aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify poss

https://www.ludc.lu.se/education-training/theses/theses-2010/magnus-ekelund - 2025-11-21

Regulation of Glucagon Secretion from pancreatic alpha cells Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insul

https://www.ludc.lu.se/education-training/theses/theses-2010/yang-zhang-de-marinis - 2025-11-21

Molecular Etiology of Graves´ Disease and Associated Ophthalmopathy Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we de

https://www.ludc.lu.se/education-training/theses/theses-2010/tereza-planck - 2025-11-21

The Role of Genetic Variation and DNA Methylation in Human Glucose Metabolism and Type 2 Diabetes The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thes

https://www.ludc.lu.se/education-training/theses/theses-2010/tina-ronn - 2025-11-21

New aspects of voltage-gated calcium channel regulation in pancreatic beta-cells. Relevance for insulin release and type 2 diabetes Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose low

https://www.ludc.lu.se/education-training/theses/theses-2011/thomas-reinbothe - 2025-11-21

Triggers of autoimmunity. Studies on gestational events The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of deve

https://www.ludc.lu.se/education-training/theses/theses-2011/sabina-lindehammer - 2025-11-21

Adaptive immune responses in atherosclerosis: Or how to prolong the use of your yellow socks Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is

https://www.ludc.lu.se/education-training/theses/theses-2011/daniel-kolbus - 2025-11-21

Genetic Variants and the Risk of Type 2 Diabetes Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and public health. Although this increase can be ascribed to both genetic and environmental factors, until 2007, the genetic factors have been largely restricted to a few candidate genes based upon our limited knowledge of the pathogenesis of the disease. In

https://www.ludc.lu.se/education-training/theses/theses-2011/anna-jonsson - 2025-11-21

Search for molecular and metabolic mechanisms contributing to impaired bet-cell function Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for

https://www.ludc.lu.se/education-training/theses/theseis-2012/siri-malmgren - 2025-11-21

Exocytosis in Type 2 Diabetes - Functional and Genetic Studies of Hormone Secretion Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts

https://www.ludc.lu.se/education-training/theses/theses-2012/sofia-andersson - 2025-11-21

Genetic and Epigenetic Influence on Oxidative Phosphorylation, Islet Function and Type 2 Diabetes in Humans The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistanc

https://www.ludc.lu.se/education-training/theses/theses-2012/anders-h-olsson - 2025-11-21

Melatonin Receptors in pancreatic Islets - Linking a Genetic Variant Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous effo

https://www.ludc.lu.se/education-training/theses/theses-2012/cecilia-nagorny-holmberg - 2025-11-21

Detecting the Vulnerable Plaque Myocardial infarction and stroke, mainly caused by a rupture of an atherosclerotic plaque, are two of the most common causes of mortality and morbidity in the world. Previous studies have pointed out inflammation, drivenby inflammatory lipids, as the keystone in the formation of the rupture prone vulnerable plaque. The risk for a plaque rupture is greatly enhanced i

https://www.ludc.lu.se/education-training/theses/theses-2013/andreas-edsfeldt - 2025-11-21

Adapt, Survive or Die; Metabolic Imbalances and the Enteric Nervous System Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest surface to the outside envir

https://www.ludc.lu.se/education-training/theses/theses-2013/ulrikke-voss - 2025-11-21

Estrogen and Serotonin - old dogs, new tricks, implications for pancreatic beta-cell function Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet hormone sec

https://www.ludc.lu.se/education-training/theses/theses-2013/alexander-balhuizen - 2025-11-21

New actors in adipocyte function - Focusing on PDEs, CART and Superantigens Obesity is increasing rapidly in all parts of the world and is now considered to be a global epidemic. Obesity is a major risk factor for several health issues such as type 2 diabetes (T2D) and cardiovascular disease. The adipose tissue is central in the maintenance of a normal energy homeostasis in the body for instance v

https://www.ludc.lu.se/education-training/theses/theses-2013/elin-banke - 2025-11-21

NFAT signaling in chronic and acute inflammation. A novel target for the treatment of diabetic vascular complications and acute pancreatitis? Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel

https://www.ludc.lu.se/education-training/theses/theses-2013/anna-zetterqvist - 2025-11-21

Mechanisms by which variants in the tcf7l2 gene increase the risk of developing type 2 diabetestype 2 diabetesxs Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the deve

https://www.ludc.lu.se/education-training/theses/theses-2014/yuedan-zhou - 2025-11-21