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Researchers at Lund University in Sweden have compared the effects of intravenous ketamine treatment with ECT treatment in severe depression. The results support the view that ketamine is a possible treatment, but also show that ECT treatment helps more people. In recent years, ketamine has emerged as a new treatment for depression, after studies have shown it to be a fast-acting antidepressant. “

https://www.medicine.lu.se/article/ect-more-effective-ketamine-severe-depression - 2025-11-03

Previous research from Lund University has shown that diabetes can be divided into five groups with different disease progression. A new study published in Nature Genetics demonstrates that there are also genetic differences between different groups of patients. An important goal of the research is to contribute with knowledge that will enable tailored treatments of patients with type 2 diabetes.

https://www.medicine.lu.se/article/new-research-highlights-genetic-differences-between-different-forms-type-2-diabetes - 2025-11-03

A lot of research explains which diets may reduce the risk of developing type 2 diabetes. Much research remains to be done about how our genes respond to the foods we eat. A new study led by researchers at Lund University adds to evidence that variations in the AMY1 gene may affect the way the body breaks down starchy foods. Unhealthy food habits are risk factors for developing type 2 diabetes. An

https://www.medicine.lu.se/article/bread-study-examines-role-genes-breaking-down-food - 2025-11-03

...showing that competitors in the Vasaloppet cross-country ski race run a lower risk of suffering from anxiety than the general population. Your results have been reported by the New York Times, CNN and many other international news outlets. Published in September last year, the article Physical Activity Is Associated With Lower Long-Term Incidence of Anxiety in a Population-Based, Large-Scale St

https://www.medicine.lu.se/article/hello-professor-tomas-deierborg-and-congratulations-considerable-international-attention-attracted - 2025-11-03

Immune Thrombocytopenia, ITP, is an autoimmune bleeding disorder that is still treated with immunosuppressive drugs that cause serious side effects. Professor John Semple’s laboratory studies the pathophysiological mechanisms behind this disease and together with Dr. Drew Provan, London, UK, has recently published the newest ideas on pathological mechanisms and therapies for the treatment and mana

https://www.medicine.lu.se/article/new-therapies-itp - 2025-11-03

Researchers in Lund have discovered an antitoxin mechanism that seems to be able to neutralise hundreds of different toxins and may protect bacteria against virus attacks. The mechanism has been named Panacea, after the Greek goddess of medicine whose name has become synonymous with universal cure. The understanding of bacterial toxin and antitoxin mechanisms will be crucial for the future success

https://www.medicine.lu.se/article/new-multipurpose-switch-inhibiting-bacterial-growth - 2025-11-03

In recent years, great advances have been made in the development of new successful immunotherapies to treat cancer. CAR T-cell therapy and antibody treatments are two types of targeted immunotherapies that have revolutionised areas of cancer care. However, there are still significant challenges in the identification of cancer cell surface proteins as targets for immunotherapies. A research group

https://www.medicine.lu.se/article/new-precision-technology-immunotherapy - 2025-11-03

New population study from Lund University Risk of bladder cancer by disease severity in relation to metabolic factors and smoking; a prospective pooled cohort study of 800,000 men and womenPrevious studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811 63

https://www.lupop.lu.se/article/risk-bladder-cancer-disease-severity-relation-metabolic-factors-and-smoking - 2025-11-03

Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use in the field of pain. R

https://www.lupop.lu.se/article/perspectives-pain-registries - 2025-11-03

Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality ratio or hazard ratio to

https://www.lupop.lu.se/article/translating-all-cause-mortality-rate-ratios-or-hazard-ratios-age-longevity-and-probability-based - 2025-11-03

Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −9

https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2025-11-03

Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in some way to the constr

https://www.lupop.lu.se/article/constructed-measures-and-causal-inference-towards-new-model-measurement-psychosocial-constructs - 2025-11-03

Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and interpretations are un

https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2025-11-03

Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compare statistical methods

https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2025-11-03

The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing participants with non-

https://www.lupop.lu.se/article/cohort-profile-and-representativeness-participants-diet-cancer-and-health-next-generations-cohort - 2025-11-03

Karin Larsson's presentation from the GIS seminar is now available Read more here.

https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2025-11-03

Recruiting participants to a clinical study is a resource-intensive process with a high failure rate. The Scottish Health Research Register (SHARE) provides recruitment support service which helps researchers recruit participants by searching patients’ Electronic Health Records (EHRs). The current study aims to evaluate the performance of SHARE in participant recruitment. Read the paper at https:/

https://www.lupop.lu.se/article/early-experience-opt-research-register-scottish-health-research-register-share-multi-method - 2025-11-03

Modern artificial intelligence techniques have solved some previously intractable problems and produced impressive results in selected medical domains. One of their drawbacks is that they often need very large amounts of data. Pre-existing datasets in the form of national cancer registries, image/genetic depositories and clinical datasets already exist and have been used for research. In theory, t

https://www.lupop.lu.se/article/registries-databases-and-repositories-developing-artificial-intelligence-cancer-care - 2025-11-03

Background: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time. Patients and Methods: We extracted systemic anticancer treatment procedures from the Danish Nati

https://www.lupop.lu.se/article/high-validity-danish-national-patient-registry-systemic-anticancer-treatment-registration-2009-2019 - 2025-11-03

The DMSKW is a valuable structure in providing safety data on drug exposure during pregnancy and lactation in combination with information on disease activity up to 6 years postpartum. This article will be the reference for describing the methods of future publications from the DMSKW. Read the paper at https://journals.sagepub.com/doi/10.1177/17562864211054956

https://www.lupop.lu.se/article/german-multiple-sclerosis-and-pregnancy-registry-rationale-objective-design-and-first-results - 2025-11-03