Filtyp
In this paper I’m concerned with the functional role of singular terms and how it can be used to construct a pragmatist theory of what it takes to understand reference. I argue that there are, at least, two distinct functions which singular terms fulfil, what I will call the talking-about and picking-out functions respectively. Both are, in one sense, ways that a term aids our understanding by spe
Background Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship to diagnostic findings and clinical phenotypes. Methods Genetic variants and clinical findings (a
High-order harmonic generation (HHG) in gases has been studied for almost 40 years under many different conditions, varying the laser wavelength, intensity, focusing geometry, target design, gas species, etc. However, no systematic investigation of the effect of the pulse duration has been performed despite its expected impact on phase-matching of the high-order harmonics. Here, we develop a compa
While delays in human-robot encounters can harm perceptions of competence, they can also enhance engagement and relatability, making timing a crucial factor in the design of robot behaviors for effective human-robot interaction. Previous research has primarily focused on how robots’ pauses or errors impact perceptions of competence, but it has not adequately addressed the complexity of timing in s
Hydrogen energy technologies are anticipated to play a fundamental role in securing a decarbonised energy future. While the deployment of low-carbon hydrogen energy systems remains nascent and is subject to a range of techno-economic constraints, potential scalability will also hinge on social acceptance. In response, this study draws on extensive national survey data to derive a comprehensive typ
National hydrogen strategies are emerging as a critical pillar of climate change policy. For homes connected to the gas grid, hydrogen may offer an alternative decarbonisation pathway to electrification. Hydrogen production pathways in countries such as the UK will involve both the gas network and the electricity grid, with related policy choices and investment decisions impacting the potential co
The Gaia satellite revealed a remarkable spiral pattern (‘phase spiral’, PS) in the z–Vz phase–plane throughout the solar neighbourhood, where z and Vz are the displacement and velocity of a star perpendicular to the Galactic plane. As demonstrated by many groups, the kinematic signature reflects the Galactic stellar disc’s response to a dynamical disturbance some 0.3–3 Gyr ago. However, previous
The skin is the outermost organ that serves as the host's live, microbiota-inhabited physical border, evolved to cope with continuous confrontation by a wide variety of environmental elements. This dynamic borderline is prone to injury and damage. Therefore, to deliver on the critical demands for protection, skin is tightly associated with innate and adaptive defense mechanisms that ensure homeost
Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare
The first generation of ELT instruments includes an optical-infrared high resolution spectrograph, indicated as ELT-HIRES and recently christened ANDES (ArmazoNes high Dispersion Echelle Spectrograph).ANDES consists of three fibre-fed spectrographs ([U]BV, RIZ, YJH) providing a spectral resolution of ∼100,000 with a minimum simultaneous wavelength coverage of 0.4-1.8 µm with the goal of extending
Background: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior desce
Molecular subtyping has been a major focus of bladder cancer research over the past decade. Despite many promising associations with clinical outcomes and treatment response, its clinical impact has yet to be defined. As part of the 2022 International Society of Urological Pathology Conference on Bladder Cancer, we reviewed the current state of the science for bladder cancer molecular subtyping. O
Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionu
A mobile gamma spectrometer's series of pulse height distributions (gamma spectra) acquired when passing a point source contains enough information to derive the distance to the source, its shielding and activity. Two Excel routines, SODAC and SSC, have been developed to determine these source parameters. SODAC determines the source-road distance by finding the best fit of the measured series of t
High energy prices recently have moved nuclear power back into the limelight. The biggest risk of nuclear industry has been large-scale accidents that give rise to ground deposition of long-lived fission products such as 137Cs, notably Chernobyl in 1986 (Ukraine) and Fukushima in 2011 (Japan). In Japan, extensive land remediation of residential areas was carried out at an estimated direct cost bet
Thyroid dose estimations after nuclear power plant (NPP) accidents are traditionally based on internal uptake of radioiodine, mainly 131I, either by instrumental measurements of thyroid uptake or by ecological estimations based on geographical dispersion of the radioiodine cloud, demographics, and food habits. However, it has been shown that 134Cs and 137Cs in some cases can be the dominant contri
The feasibility of the global energy transition may rest on the ability of nations to harness hydrogen's potential for cross-sectoral decarbonization. In countries historically reliant on natural gas for domestic heating and cooking such as the UK, hydrogen may prove critical to meeting net-zero targets and strengthening energy security. In response, the UK government is targeting industrial decar
Breath-hold ECG-gated cardiovascular magnetic resonance (CMR) imaging is challenging during exercise due to motion, ECG-problems, and lengthy scans. To facilitate time-resolved volumetric measures from exercise-CMR, we aimed to develop a method for constructing time-resolved ventricular cines from real-time free-breathing exercise-CMR. Time-resolved ventricular cines were semi-automatically constr
Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood. Methods: We conducted a nested case-control study of 549
