Investigation of novel malaria parasite enzyme (DHODH) inhibitors based on 4-amino-3-benzylcoumarin and 4-amino-8-azacoumarin scaffolds
Abstract Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed chemotherapeutics. The de novo pyrimidine biosynthesis enzymes offer potential as targets for drug design, because, unlike the host, the parasite lacks pyrimidine salvage pathway.In search for new Plasmodium falciparum dihydroorotate dehydrog
