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Tumor response mechanisms and treatment effects of alpha1-oleate
Impact of different carbon labels on consumer inference
Carbon labelling of food products serves as a demand-side tool with the potential to drive the essential shift in consumption patterns toward reducing climate impact. For carbon labels to influence food choices, they must enable consumers to recognize and adopt purchasing behaviour that lower their climate footprint. While inference plays a critical role in facilitating behavioural change, evidenc
Using SILMAS to improve machine learning-assisted quantification of pathology
In this study, we investigate the benefits of using structured illumination light-sheet microscopy with axial sweeping (SILMAS) in the context of neural network-assisted quantification of pathology in volumetric data. A bottleneck for training a neural network is the availability of manually labeled training data that adequately covers the variance in unseen samples, allowing the network to correc
Tourism satellite account for Sweden 1992-93
This paper calculates the consumption expenditure of internal visitors in Sweden, and Swedes' expenditures on outboard tourism, according to the WTO definition of tourism expenditure. The demand-based calculations of national tourism are distributed among same-day visitors and overnight visitors, for leisure and business purposes. The supply side calculations cover the main tourism industries. Dai
A new approach to modelling and forecasting monthly guest nights in hotels
Starting from a day-to-day model on hotel specific guest nights we obtain an integer-valued moving average model by cross-sectional and temporal aggregation. The two parameters of the aggregate model reflect mean check-in and the check-out probability. Letting the parameters be functions of dummy and economic variables we demonstrate the potential of the approach in terms of interesting interpreta
Enhancing Photothermal Therapy Against Breast Cancer Cells by Modulating the End Point of Gold Shell-Isolated Nanoparticles Using Nanostraw-Assisted Injection
Gold shell-isolated nanoparticles (AuSHINs) are promising photothermal therapy (PTT) agents for cancer treatment due to their excellent photoconversion efficiency, biocompatibility, colloidal stability, and tunable properties, including size, shape, and surface functionalization. However, their therapeutic efficacy in in vitro assays is often limited by poor cellular uptake and lysosomal entrapmen
Aerosolized Dornase Alfa (DNase I) for the Treatment of Severe Respiratory Failure in COVID-19 : A Randomized Controlled Trial
Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa
Cloud-scale Gas Properties, Depletion Times, and Star Formation Efficiency per Freefall Time in PHANGS-ALMA
We compare measurements of star formation efficiency to cloud-scale gas properties across the PHANGS- ALMA sample. Dividing 67 galaxies into 1.5 kpc scale regions, we calculate the molecular gas depletion time τ dep mol = Σ mol / Σ SFR and the star formation efficiency per freefall time ϵ ff mol = τ ff / τ dep mol for each region. Then we test how τ dep mol and ϵ ff mol vary as functions of the re
Patient-reported outcome measures are urgently needed for patients with skin of colour who have atopic dermatitis
Response to Letter to the Editor from Candemir and Çakal : "24-Hour Urine Calcium Predicts Reduced Fracture Incidence and Improved Bone Mineral Density after Surgery for Primary Hyperparathyroidism"
Advancing regulatory dialogue : In silico models for improved vaccine biomanufacturing - an expert meeting report
On March 30, 2022, Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), organised a hybrid workshop, titled “Regulatory Dialogue for Road Maps of Implementation of New Tools in Chemistry, Manufacturing, and Controls Dossiers.” This event brought together modellers, regulatory experts, and academic and industry professionals specialising in vaccine process
Stained DNA Dot Detection (SD3) : An automated tool for quantifying fluorescent features along single stretched DNA molecules
The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally read using sequencing methodologies. DNA can, however, also carry other important information, such as epigenetic marks and DNA damage. This information has recently been visualized along single DNA molecules using fluorescent labels. Quantifying fluorescent labels along DNA is
Unveiling the Local Fate of Charge Carriers in Halide Perovskite Thin Films via Correlation Clustering Imaging
As the field of metal halide perovskites matures, a range of compositionally different perovskite films has found a place in efficient optoelectronic devices. These films feature variable local structural stability, carrier diffusion, and recombination, while there is still a lack of easy-to-implement generic protocols for high-throughput characterization of these variable properties. Correlation
Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy : an ERA Registry study
Background. Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category ‘miscellaneous’ or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic ki
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies : Proceedings of the Tau2024 Global Conference
Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss
Unraveling the origins of top managers’ intrapersonal diversity decision
Intrapersonal diversity has emerged as an important trait among top managers, significantly improving firm and team performance. However, existing research treats this diversity as static orexogenously given, overlooking its developmental origins. Drawing on imprinting theory, we explore how early-childhood parental diversity and later-life crisis events shape a manager’s decision to acquire this
Modelling district heating and cooling : analysis of network costs and configurations for a decarbonised heat and cold supply
District heating and cooling is a simple but powerful technology that could contribute to decarbonising Europe's heating and cooling supply. However, its current overall penetration is minor. Furthermore, future systems could adopt different configurations with various settings of temperature levels or production location. This thesis has aimed to improve existing tools to evaluate district heatin
Contributions of injury deaths to changes in life expectancy and disparity : A comparative analysis of G7 countries over two decades
BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017