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Miniature bladder tumors in a 3D cell culture Bladder cancer is a common cancer type and represents a complex disease that causes high mortality if not treated properly. To find new treatments and optimize current therapies, expanding research model systems is important. The aim of this Master’s Project was to establish and optimize a newly popularized organoid method on bladder cancer cells. Ou
Kan vissa läkemedel leda till spelberoende? I kroppen baserar ofta många processer på en och samma substans. Exempelvis finns det olika kommunikationssystem i hjärnan som använder sig av signalämnet dopamin. Därför kan det uppstå biverkningar när man försöker påverka ett av dessa system med läkemedel, till exempel i behandling av Parkinsons sjukdom, restless legs syndrom eller schizofreni. Den hä
This essay analyzes the differences and similarities in the most recent EU and U.S. elections. A narrative analysis is employed, and the theory is based on a social constructionist approach to knowledge. An analytical framework is developed comparing categories/contents of right-wing populism and democracy in relation to the narrative elements building on Labov och Waletskys (1967). The study show
Det här arbetet handlar om en genmodifierad och plastproducerande mikroorganism och hur den kan odlas. Plast är en oumbärlig del av vårt dagliga liv. Maten vi köper är paketerad i plast och vårt dricksvatten leds i plaströr i marken. Tyvärr är stor del av den plast som produceras idag gjord av kemikalier som härstammar från fossil olja. Användning av fossil olja är något som man vill undvika för aTo reduce pollution and green house gas emissions associated with plastic production and waste, biobased production of the biodegradable plastic, polyhydroxybutyrate (PHB), is suggested to be a good substitute to petrochemically derived plastics used in foodstuff packaging. However, bacterial production of PHB has proven costly and production with plants occurs at the expense of arable land. Oleag
Cytochrome c oxidases - why you need copper to breathe The next time anyone will ask you to provide any proof of evolution, you can surprise them by mentioning cytochrome c oxidases. Not only this answer will make you look smart and knowledgeable, but it will also provide a very solid example of something that brings together any oxygen-breathing organism, from the smallest bacterium to a majesti
How we as viewers emotionally connect and interact with art and other aesthetic experiences is a widely debated topic in the art historical discourse. Following German aesthetician and philosopher Robert Vischer’s theorisation of the concept of Einfühlung during the 1870s, the empathic discourse has intrigued and engaged thinkers throughout centuries. With the discovery of mirror neurons in the hu
Transcriptional Burst Kinetics of Dosage Compensation in Chicken Sex chromosome combinations are different between sexes in many animal species. In therian mammals, females hold XX and males hold XY, which is called male heterogametic system. In birds, the sex chromosome system is female heterogametic (ZZ in males and ZW in females). The gene dosage imbalance between sexes (Xm:XXf or Zf:ZZm) and
Antimicrobial resistance (AMR) is a growing problem worldwide as more drug-resistant bacteria are identified. However, resistance is comparably rare against antibiotics that target the cytoplasmic membrane. Membrane thickness is an important factor for the mode of action of these antibiotics, and difficult to study. Thus, constructing a biosensor to measure membrane thickness in vivo is of great i
Sustainability transition research investigates why the necessary change towards more sustainable patterns of consumption and production has not yet been achieved and how it can be accelerated. Taking into account the complexity of the globalised dynamics underlying today's sustainability challenges, it has been suggested that the existence of global regimes limits the possibilities for change
Uppsatsen utforskar vilka historiedidaktiska perspektiv man kan tillämpa på de populära Assassin's Creed-spelen, med fokus på Assassin's Creed II och Assassin's Creed: Brotherhood. Historiebruk, historiekultur och historiemedvetande, vilka tillsammans bildar den historiedidaktiska teorin, utgör de teoretiska underlagen. Det metodologiska tillvägagångssättet är en kombinerad text- och b
Current post-carbon transition trajectories are primarily based on a belief in technical solutions wherein considerations of the citizens’ role in collective mobilisation and transformation are largely overlooked. To this end, the thesis seeks to understand how citizens can become active agents of change within transition efforts and how their political agency can be empowered accordingly. This, b
There are many advantages with the development towards Integrated Circuits (ICs) with smaller, faster, and more transistors. However, tighter margins lead to a need of on-chip instruments to test, tune, and configure. These on-chip instruments, which can be in the range of thousands per IC, must be accessed through the life-time. However, access is challenged by complex system hierarchies. When IC
The aim of this study was to examine pollution-induced community tolerance (PICT) of biofilm communities induced by chemical mixtures, characteristic of agricultural aquatic environments. Additionally, the use of biofilms as a natural passive sampler was investigated. In situ biofilms grown on artificial substrate for 4 to 6 weeks from sites located in agricultural areas were used to conduct a PIC
In this project, I start by addressing the issue of the creativity decrease that happen within children when they start school. I wanted to emphasize the importance of creative play to develop problem-solving skills. After I ran some user tests, my project took a new turn and instead I started designing a board game for an older target group. The aim of the game is to improve the visual comm
Maternal Rotavirus antibodies inhibit rotavirus specific B cell responses in offspring For infants, the period following birth is marked by a developmentally immature immune system and increasing exposure to pathogens, however it is also a period in which maternally derived antibodies are still present in the neonate. These antibodies are obtained during pregnancy through the placenta and follow
The construction industry is expected to generate 2.2 billion tons of waste by the year 2025 and was responsible for 39 % of GHG emissions generated by the building processes and energy consumption, in 2017. In 2018, the Swedish construction industry accounted for 21 % of the total GHG emissions (including imported emissions) and 35 % of the total amount of waste in the country. In these past deca
Hur cancerceller ska bli bättre på att göra sig synlig för immunförsvaret Immunförsvaret består utav många olika celler som alla är med i att försvara kroppen från hot, när dom upptäcker en fara finns en del celler som kan eliminera målet, dom kallas T-celler. Ett hot som uppkommer i kroppen är cancer. Det finns många olika orsaker till att cancer uppstår, däribland arvsanlag men också miljöfaktoThe many cases of malignant melanoma and the following relapses after standard-of-care treatment demands inventions on finding new treatment to this cancer disease. One of the reasons for reduced clinical response in melanoma is the downregulation of tumor specific antigens which results in decreased tumor recognition, followed by tumor escape and progression. This study investigated the potential
Transports, and transport infrastructures enable and deliver vital societal functions in today’s society. At the same time, as sustainability becomes more and more important these sectors fail to enable the rate of change that international and national policies calls for. The electrification of the transport sector is a key driver of the future’s sustainable transport system, and the number of el
Previous research has shown that intermediate-advanced L2 learners of Swedish with a non-tonal L1 can use word accents to predict the upcoming suffix as L1 Swedish speakers do. This was also the case of low-intermediate L2 learners who produced word accents after being instructed on the Swedish prosodic system. On the contrary, previous findings on L2 Swedish learners with a tonal L1 exhibited no
The project aims to learn about Chinese young people's choices and attitudes towards cooking and solve their problems in cooking. The solution is presented in the form of a product --- a multifunctional electrothermal cooking appliance. The traditional Chinese saying "Food is god for the people" shows the importance of diet in Chinese life. But today, more and more Chinese young peo
