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Term synonymous variation is widely used, but frequently in a wrong or misleading meaning and context. Twenty three point eight % of possible nucleotide substitution types in the universal genetic code are for synonymous amino acid changes, but when these variants have a phenotype and functional effect, they are very seldom synonymous. Such variants may manifest changes at DNA, RNA and/or protein

Through a systematic review and a series of meta-analyses, we evaluated the general responsiveness of putative transcriptional biomarkers of general toxicity and chemical stress. We targeted metal exposures performed on bivalves under controlled laboratory conditions, and selected six transcripts associated with general toxicity for evaluation: catalase (cat), glutathione-S-transferase (gst), heat

Under de senaste åren har ord som krig, kris och råvarubrist varit hett nyhetsstoff. Pandemin och Rysslands krig i Ukraina har visat hur sammanlänkade vi är i en global ekonomi. Men redan på 1800-talet, mitt under brinnande inbördeskrig i USA, drabbades världen av sin första globala råvarukris. ”Bomullskrisen” orsakades av en exportblockad av bomull från de amerikanska sydstaterna och påverkade EuUnder de senaste åren har ord som krig, kris och råvarubrist varit hett nyhetsstoff. Pandemin och Rysslands krig i Ukraina har visat hur sammanlänkade vi är i en global ekonomi. Men redan på 1800-talet, mitt under brinnande inbördeskrig i USA, drabbades världen av sin första globala råvarukris. ”Bomullskrisen” orsakades av en exportblockad av bomull från de amerikanska sydstaterna och påverkade Eu

Vaccination to prevent influenza virus infection and to lessen its severity is recommended among healthcare workers (HCWs). Health professionals have a higher risk of exposure to viruses and could transmit the influenza virus to vulnerable patients who are prone to severe disease and mortality. The aim of the current study was to evaluate the levels of influenza vaccine acceptance and uptake as we

The transition of industrial production from petrochemistry to a more sustainable economy requires the use of carbon neutral, renewable feedstock, which does not compete with food and feed supplies – by-products of farming and agro-food industry offer this possibility. With a limited range of low-value applications today coupled with the need for maximal utilisation of resources, the by-products o

PurposeThis paper aims to examine how CEO talk of sustainability in CEO letters evolves in a period of increased expectations from society for companies to increase their transition towards becoming more sustainable and to better account for progress and performance within the sustainability areas.Design/methodology/approachBy adopting an interpretive textual approach, the paper provides a careful

COVID-19 vaccine hesitancy poses a threat to the success of vaccination programmes currently being implemented. Concerns regarding vaccine effectiveness and vaccine-related adverse events are potential barriers to vaccination; however, it remains unclear whether tailored messaging and vaccination programmes can influence uptake. Understanding the preferences of key groups, including students, coul

Detta arkiv innehåller en tematiserad sammanställning av forskningsdata som samlats in i intervjuer med personer som har egna erfarenheter av asylprocessen i Sverige, personer som har erfarenheter av asylkontexten genom sina yrken och personer ur civilsamhället som har engagerat sig på frivillig basis för att stödja människor i asylprocess. Materialet är hämtat från projektet Insamling av forsknin

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast canc

Polymeric anion-exchange membranes (AEMs) with alkali-stable quaternary ammonium (QA) cations are essential components for the development of alkaline membrane fuel cells and water electrolyzers. Ionic loss by β-elimination reactions typically accelerates at low water contents, i.e., high alkali concentrations, which makes QA cations attached to polymer backbones via benzylic sites interesting alt

Detta kapitel har för avsikt att inspirera till metoder för ett alternativt sätt att bedriva forskning och antirasistiskt socialt arbete. Med avstamp i Lena Dominellis analys av hur vi är fångade i en rasistisk och patriarkal världsordning och hur detta drabbar väldigt många människor och samhällen, diskuterar vi med Asylkommissionen som exempel våra erfarenheter av en forskningspraktik med antira

The study of slavery and coerced labour is increasingly conducted from a global perspective, and yet a dual Eurocentric bias remains: slavery primarily brings to mind the images of Atlantic chattel slavery, and most studies continue to be based – either outright or implicitly – on a model of northern European wage labour. This book constitutes an attempt to re-centre that story to Asia.With studie

This global microhistorical analysis of the Swede Brigitta Scherzenfeldt’s capture in Russia and her subsequent enslavement in the Dzungar khanate stresses actors and regions needed to nuance the history of globalisation. The early globalisation process is commonly exemplified with maritime contacts, involving free and often male West European actors. In contrast, this study combines multilingual

Persons with stress-related disorders, mental disorders and neuropsychiatric disabilities are in particular vulnerable to cognitive challenges at the workplace. The barriers faced by persons with communicative, social and cognitive disabilities are most often invisible to persons in the environment. The objective of the study presented in this paper is to develop and test a tool that increases awa

The centre of the research ‘Conversation Costume’ was an investigation of co-creational costume process. An important starting point for the research was verbal and non-verbal conversations. One aspect of the conversation was the practice of listening, for example, sensing the costume ‘things’, ourselves, each other, and the space as costume-body-space-improvisations. Another aspect of the convers

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder characterized by excessive heart rate increase on standing, leading to debilitating symptoms with limited therapeutic possibilities. Proteomics is a large-scale study of proteins that enables a systematic unbiased view on disease and health, allowing stratification of patients based on their protein background.

The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccina

Voltage-gated Ca2+ (CaV) channel dysfunction leads to impaired glucose-stimulated insulin secretion in pancreatic β-cells and contributes to the development of type-2 diabetes (T2D). The role of the low-voltage gated T-type CaV channels in β-cells remains obscure. Here we have measured the global expression of T-type CaV3.2 channels in human islets and found that gene expression of CACNA1H, encodi