BACKGROUND AND AIM: Cigarette smoking is the most common cause of chronic obstructive pulmonary disease (COPD) but more mechanistic studies are needed. Cigarette smoke extract (CSE) can elicit a strong response in many COPD-related cell types, but no studies have been performed in lung fibroblasts. Therefore, we aimed to investigate the effect of CSE on gene expression in lung fibroblasts from hea

Background/Aims: Postural orthostatic tachycardia syndrome (POTS) is a chronic condition in which patients show a marked increase in heart rate on standing, but also suffer from a range of additional symptoms, which may include fatigue and difficulty in concentration. This study’s aim was to investigate the role of psychological stress, resilience, and lifestyle as possible contributing factors in

Online platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, FlashbackOnline platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, Flashback

Världens enklaste kulspetspenna dyker upp tidigt i min intervju med den pensionerade och ytterst erfarne – för att inte säga slipade – försäljaren Rolf. Under hela sitt yrkesliv var han verksam i ett konsultbolag med uppdrag över hela världen. Han arbetade med att sälja tjänster till företag och offentliga institutioner i olika länder, framför allt i Mellanöstern men även i Öst- och Sydeuropa. I d

In health care, the provision of pertinent information to patients is not just a moral imperative but also a legal obligation, often articulated through the lens of obtaining informed consent. Codes of medical ethics and many national laws mandate the disclosure of basic information about diagnosis, prognosis, and treatment alternatives. However, within publicly funded health care systems, other k

While organizations providing critical services to society must have the ability to anticipate and prepare for foreseeable threats, they also need to develop a capacity to adapt in the face of unforeseen challenges and crises. While adaptive capacity becomes manifested in a specific situation through the concrete adaptations carried out by an organization, the preconditions to adapt exist already

Abstract in FrenchLe populisme invoque l’autorité du peuple contre une élite. Souvent, cela implique un rejet de l’autorité des experts et de leurs critères de validité du discours. Cette tension apparaît dans les conflits autour des théories de la conspiration. Est suggéré que cette tension soit considérée comme un conflit entre deux interprétations de la réalité, de phénomènes particuliers ou dePopulism invokes the authority of the people against an élite. Often that entails a rejection of the authority of experts and their criteria for a valid discourse. This tension surfaces in conflicts around conspiracy theories and here is suggested that this tension is seen as a conflict between two interpretations of reality, of particular phenomena or history. The question is what role the philos

Climate change is increasingly affecting human well-being and will inevitably impact on occupational sectors in terms of costs, productivity, workers' health and injuries. Among the cooling garment developed to reduce heat strain, the ventilation jacket could be considered for possible use in workplaces, as it is wearable without limiting the user's mobility and autonomy. In this study, simulation

Recension av Caterina Stenius essäsamling Sanningen är alltid större – En essä på sju famnars djup, Vasa Scriptum, 2022.

Two-dimensional electronic spectroscopy (2DES) is a popular technique that can track ultrafast coherent and incoherent processes in real time. Since its development in the late 1990s, 2DES has become a powerful tool for investigating ultrafast dynamics in a range of systems, including nanomaterials and optoelectronic devices. This Primer explains the underlying physical principles of 2DES and how

The spatial prediction of the turbulent flow of the unsteady von Kármán vortex street behind a cylinder at Re = 1000 is studied. For this, an echo state network (ESN) with 6000 neurons was trained on the raw, low-spatial resolution data from particle image velocimetry. During prediction, the ESN is provided one half of the spatial domain of the fluid flow. The task is to infer the missing other ha

ObjectivesBeing met with empathy increases information sharing, treatment coherence, and helps patients to recover faster. However, we do not know how the content of the conversation about disease progression, new treatments, or other issues concerning serious illness affects patients' perceptions of the physician's empathy, and thus, the quality of the conversation. This study aimed to test the h

The family Simuliidae includes more than 2000 species of black flies worldwide. Their morphological uniformity creates difficulty for species identification, which limits our knowledge of their ecology and vectorial role. We investigated the systematics of black flies in a semiarid area of the Iberian Peninsula, an ecologically harsh environment for these organisms. Sampling adult black flies in t

Introduction Atrial fibrillation (AF) is a major risk factor for ischaemic stroke and transient ischaemic attack (TIA), and AF detection can be challenged by asymptomatic and paroxysmal presentation. Long-term ECG monitoring after ischaemic stroke or TIA is recommended by all major societies in cardiology and cerebrovascular medicine as a secondary prophylactic measure. However, data on stroke red

PURPOSE: To describe the clinical presentation and treatment outcomes in a nationwide cohort of patients with giant prolactinomas. METHODS: Register-based study of patients with giant prolactinomas [serum prolactin (PRL) > 1000 µg/L, tumor diameter ≥40 mm] identified in the Swedish Pituitary Register 1991-2018. RESULTS: Eighty-four patients [mean age 47 (SD ±16) years, 89% men] were included in th

In order to achieve environmental goals, the impact of the European building stock on the environment needs to be reduced through renovation measures. However, regarding heritage buildings, the choice of measure(s) must simultaneously consider the preservation of cultural and historical values. Besides the impact on such values, energy-efficiency measures can result in increased risks for moisture