The stimulator of interferon genes (STING) plays a significant role in immune defense and protection against tumor proliferation. Many cyclic dinucleotide (CDN) analogues have been reported to regulate its activity, but the dynamic process involved when the ligands activate STING remains unclear. In this work, all-atom molecular dynamics simulations were performed to explore the binding mode betwe

Climate may regulate dissolved organic carbon (DOC) composition across the peat-water interface, but experimental evidence is scarce. We manipulated the climate in peatland and recipient surface water mesocosms to reflect four different climate warming scenarios. In half of the mesocosms, the water level was managed to avoid drought, after which responses were recorded during two annual cycles. It

We continue our work on the light-front formulation of quarkonium γ∗γ transition form factors, extending the formalism to JPC = 2++ tensor meson states. We present an analysis of γ∗γ → χc2 transition amplitude and the pertinent helicity form factors. Our relativistic formalism is based on the light-front quark-antiquark wave function of the quarkonium. We calculate the two-photon decay width as we

We present the first data release of VELOcities of CEpheids (VELOCE), dedicated to measuring the high-precision radial velocities (RVs) of Galactic classical Cepheids (henceforth, Cepheids). The first data release (VELOCE DR1) comprises 18 225 RV measurements of 258 bona fide classical Cepheids on both hemispheres collected mainly between 2010 and 2022, along with 1161 observations of 164 stars, m

Introduction: Lichen planus is a relatively common inflammatory condition of the nails, skin, and mucosal surfaces. Oesophageal involvement of lichen planus is thought to be very rare, mainly described in case reports, but is associated with a high risk of oesophageal stenosis as well as squamous cell carcinoma. No evidence-based treatment recommendations exist, with the majority of described trea

In recent years there has been a renewed interest in the basal forebrain cholinergic system as a target for the treatment of cognitive impairments in patients with Parkinson's disease, due in part to the need to explore novel approaches to treat the cognitive symptoms of the disease and in part to the development of more refined imaging tools that have made it possible to monitor the progressive c

Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identifie

Despite a strong emphasis that individual support services should be provided according to needs, the Swedish welfare system often use age to organize support. A change in the Social Service Act in 2018 allows municipalities to provide home care for people above a decided age without individual any assessment of needs. Political parties and pensioners’ organizations’ have proposed for the introduc

Istället för att kräva sin rätt har äldre förståelse för personalens stressiga situation och accepterar att inte få sina behov tillgodosedda, skriver Håkan Jönson, Tove Harnett och Glenn Möllergren, forskare vid Socialhögskolan i Lund.Företrädare för Kristdemokraterna i Malmö, Lars Hector, Anna Reimer och Henrik Reimer, kritiserar den så kallade minutstyrningen inom hemtjänsten i staden och förkla

BackgroundThe goal of the Fifth Annual Baylor College of Medicine & DNAnexus Structural Variation Hackathon was to push forward the research on structural variants (SVs) by rapidly developing and deploying open-source software. The event took place in-person and virtually in August 2023, when 49 scientists from 14 countries and 8 U.S. states collaboratively worked on projects to address critic

Introduction: FLASH radiotherapy (RT) has emerged as a promising modality, demonstrating both a normal tissue sparing effect and anticancer efficacy. We have previously reported on the safety and efficacy of single fraction FLASH RT in the treatment of oral tumors in canine cancer patients, showing tumor response but also a risk of radiation-induced severe late adverse effects (osteoradionecrosis)

A generalized approach derived from Bloch's equation of motion of nuclear magnetic moments is presented to model the frequency, magnetic field, spin density, and temperature dependencies in the electromagnetic permeability tensor for materials with magnetic resonances. The resulting tensor model predicts characteristic polarization signatures which can be observed, for example, in Mueller matrix e