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Impact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

Introduction: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). Material and method

EURO-B.O.S.S. : A European study on chemotherapy in bone-sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma

INTRODUCTION: The EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) was the first prospective international study for patients 41-65 years old with high-grade bone sarcoma treated with an intensive chemotherapy regimen derived from protocols for younger patients with high-grade skeletal osteosarcoma.METHODS: Chemotherapy based on doxorubicin, cisplatin, ifosfamide, and methotrexate was suggested

Inguinal Hernia Surgery in Men - Chronic Pain and Sexual Dysfunction

Life time occurrence of inguinal hernia is 30% of men. Most are symptomatic and will require surgical treatment. Operation will commonly cure the hernia but remaining chronic pain or new pain is seen in 10–15%. Groin pain due to an inguinal hernia can cause impairment of sexual functions. This is sparsely studied. The aim was to analyse postoperative long term chronic pain and sexual impairment in

The Relevance of Sexual Dysfunction Related to Groin Pain After Inguinal Hernia Repair : The SexIHQ Short Form Questionnaire Assessment

Background: Chronic postoperative pain after inguinal hernia surgery can affect sexual function. A new short form questionnaire for inguinal hernia pain related sexual dysfunction (SexIHQ) was introduced and applied to a register based cohort of total extra-peritoneal hernioplasty (TEP) operated patients. Methods: Sexually active men, 30–60 years old, recorded in the Swedish Hernia Register for a

How task demands influence scanpath similarity in a sequential number-search task

More and more researchers are considering the omnibus eye movement sequence—the scanpath—in their studies of visual and cognitive processing (e.g. Hayes, Petrov, & Sederberg, 2011; Madsen, Larson, Loschky, & Rebello, 2012; Ni et al., 2011; von der Malsburg & Vasishth, 2011). However, it remains unclear how recent methods for comparing scanpaths perform in experiments producing variable

Microsaccade detection using pupil and corneal reflection signals

In contemporary research, microsaccade detection is typically performed using the calibrated gaze-velocity signal acquired from a video-based eye tracker. To generate this signal, the pupil and corneal reflection (CR) signals are subtracted from each other and a differentiation filter is applied, both of which may prevent small microsaccades from being detected due to signal distortion and noise a

Rules of engagement - Regulation of complement response in tissue

Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.The work in

Working towards paradise; an interdisciplinary theoretical framework for environmental peacebuilding

Exploring the human-environment nexus and linkages between (post-conflict) political developments and environmental dimensions, this paper reflects on the development of interdisciplinary theories of environmental peacebuilding. Theories of environmental peacebuilding come from a variety of different disciplines within the social and biophysical sciences; warfare ecology (Machlis et al. , 2011), e

Every day peace: the ignored role of Civil Society in the Syrian Uprising

This paper discusses the role of civil society in the Syrian war between 2012 and 2016, specifically in the so-called "liberated areas" under the control of the Free Syrian Army and the Syrian opposition. A postdoctoral research project of Copenhagen University between 2014 and 2016, has investigated the role of citizen video journalists and peaceful activists in the Syrian uprisings. Responding t