De novo mutations (DNMs) are drivers of genetic disorders. However, the study of DNMs is hampered by technological limitations preventing accurate quantification of ultra-rare mutations. Duplex Sequencing (DS) theoretically has < 1 error/billion base-pairs (bp). To determine the DS utility to quantify and characterize DNMs, we analyzed DNA from blood and spermatozoa from six healthy, 18-year-old S

We present a new instrument, "Boreas", a cryogen-free methane (CH4) preconcentration system coupled to a dual-laser spectrometer for making simultaneous measurements of δ13C(CH4) and δ2H(CH4) in ambient air. Excluding isotope ratio scale uncertainty, we estimate a typical standard measurement uncertainty for an ambient air sample of 0.07‰ for δ13C(CH4) and 0.9‰ for δ2H(CH4), which are the lowest r

Non-traditional stable isotope systems are increasingly used to study micronutrient cycling and acquisition in terrestrial ecosystems. We previously proposed for zinc (Zn) a conceptual model linking observed isotope signatures and fractionations to biogeochemical processes occurring in the rice soil environment and we suggested that 2’deoxymugineic acid (DMA) could play an important role for rice

The 2015 Paris Agreement of the United Nations Framework Convention on Climate Change aims to keep global average temperature increases well below 2 °C of preindustrial levels in the Year 2100. Vital to its success is achieving a decrease in the abundance of atmospheric methane (CH4), the second most important anthropogenic greenhouse gas. If this reduction is to be achieved, individual nations mu

Under the UK-focused Greenhouse gAs and Uk and Global Emissions (GAUGE) project, two new tall tower greenhouse gas (GHG) observation sites were established in the 2013/2014 Northern Hemispheric winter. These sites, located at existing telecommunications towers, utilized a combination of cavity ring-down spectroscopy (CRDS) and gas chromatography (GC) to measure key GHGs (CO2, CH4, CO, N2O and SF6)

We reconstruct atmospheric abundances of the potent greenhouse gas span classCombining double low line inline-formula span classCombining double low line inline-formula perfluorocyclobutane, perfluorocarbon PFC-318) from measurements of in situ, archived, firn, and aircraft air samples with precisions of span classCombining double low line inline-formula reported on the SIO-14 gravimetric calibrat

Atmospheric inverse modelling has become an increasingly useful tool for evaluating emissions of greenhouse gases including methane, nitrous oxide, and synthetic gases such as hydrofluorocarbons (HFCs). Atmospheric inversions for emissions of CO2 from fossil fuel combustion (ffCO2) are currently being developed. The aim of this paper is to investigate potential errors and uncertainties related to

Hydrofluorocarbons (HFCs) are used in a range of industrial applications and have largely replaced previously used gases (CFCs and HCFCs). HFCs are not ozone-depleting but have large global warming potentials and are, therefore, reported to the United Nations Framework Convention on Climate Change (UNFCCC). Here, we use four independent inverse models to estimate European emissions of the two HFCs

This proposal addresses the profile area: Art, Technology, Materiality, by focusing on discussions of the nature of the materiality of artistic practice and its implications. The proposal considers the interplay between making and thinking, encompassing both the human and the non-human, resulting in co-constructed knowledge and meaning through performative and textile practices. This performative

BackgroundWe aimed to fill the gaps of knowledge concerning incidence rates and temporal trend, clinical features and risk factors for death for M. morganii bloodstream infections in south Sweden.MethodsThis was an observational, population-based study including all patients with at least one blood culture positive for Morganella morganii between 2013-2023 in Skåne, south Sweden.ResultsA total of

OBJECTIVES: Carbapenem- and colistin-resistant Klebsiella pneumoniae were isolated from war victims treated in hospitals in Ukraine. The question was whether these pandrug-resistant K. pneumoniae are pathogenic and capable of causing disease in a broader context.METHODS: Klebsiella pneumoniae clinical isolates (n = 37) were tested for antibiotic resistance and subjected to whole-genome sequencing

We investigate the problem of low-complexity, high-dimensional channel estimation with beamspace observations, for the purpose of localization. Existing work on beamspace ESPRIT (estimation of signal parameters via rotational invariance technique) approaches requires either a shift-invariance structure of the transformation matrix, or a full-column rank condition. We extend these beamspace ESPRIT

Scientists have found an alternative way to produce atoms of the superheavy element livermorium. The new method opens up the possibility of creating another element that could be the heaviest in the world so far: number 120.

Objectives: Antihistamines have been reported to be linked with less pain in osteoarthritis. We aimed to estimate associations between antihistamine use and three outcomes: prevalent osteoarthritis, current joint pain, and developing osteoarthritis. Methods: We included 25 003 participants of EpiHealth – a cohort of persons aged 45 to 75 from Malmö/Uppsala in Sweden. Participants self-reported the

Understanding the counter-flow of liquid inlet and gas outlet at the interface between the electrolyte and cathode gas diffusion layer (GDL) is crucial for water management in proton exchange membrane fuel cells. Existing studies typically overlook air outlets and assume a fixed liquid inlet direction. This study uses a volume of fluid method to model two-phase interactions in a T-shaped GDL and g

BackgroundHospitalization indicates the presence of severe disease and constitutes a leading cost in health care. We aimed to prospectively assess if prevalent diabetes mellitus contributes to excess all-cause and cause-specific hospital admissions and mortality at the population level.MethodsWe used a Swedish prospective population-based cohort, including 25,642 individuals of whom 4.2% had preva

In the face of climate change, governments are scaling up public investments in mitigation efforts and green technologies. However, critics question the ability of public funding agencies to promote the most promising innovations. This paper contributes to this debate by presenting a long-term database, that directly links Swedish innovations to public funding between 1970 and 2021. We use logisti

Har du gjort något du inte borde? Eller ångrat vad du aldrig gjorde?Vi löser ditt dilemma på plats!Tre operasångare och en pianist improviserar en unik föreställning om dina små och stora vägval.Operaimprovisatörerna tar dig med på en spektakulär resa på de outforskade vägarna genom ”Operamultiversumet” där dina dilemman, minnen och funderingar ger upphov till nya kammaroperor och operetter.”Vad hFöreställning i Laholms Stadspark inom ramen för Halland Opera and Vocal Festival