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Cell type deconvolution - the computational estimation of cellular composition in bulk tissue samples - is a valuable tool in cancer research for understanding immune infiltration and tissue heterogeneity. Most deconvolution algorithms infer the composition of cell types in bulk samples by modeling the observed expression data as a linear combination of reference expression profiles from each cell
Adsorption onto chromium surfaces during heat treatment (65–68°C) of β-lactoglobulin A and B in phosphate buffer, pH 6.88, was investigated byin situellipsometry. Thermal unfolding andin situheat-induced aggregation under the same conditions were studied by differential scanning calorimetry and dynamic light scattering, respectively. A lag phase was observed for buildup of the thickness of the
EU:s koncentrationsförordning syftar till att skydda konkurrensen på den inre marknaden från skada som orsakas av betydande strukturella förändringar, genom att säkerställa att företagsförvärv och fusioner leder till ökad tillväxt och en högre levnadsstandard inom EU. Denna uppsats undersöker det rättsliga ”vakuum” som uppstår utanför förordningens tillämpningsområde, samt hur den praktiska tillämThe EU Merger Regulation aims to protect the common market from lasting damage to competition caused by significant structural changes, by ensuring that mergers and acquisitions ultimately lead to improved growth and a higher standard of living within the EU. This thesis examines the regulatory gap outside the scope of the EU Merger Regulation, and how the practice of EU merger control has evolved
This thesis explores the Brazilian State logic of criminalization or legitimization of violence through two important cases: the 1992 Carandiru massacre, in which 111 inmates were assassinated by the military police, and the 2013-2014 Black Bloc demonstrations in which 23 activists were criminalized. Aiming to challenge entrenched ideas about violence, the research investigates who benefits from t
BackgroundHematoma location may influence hematoma volume and risk of expansion, the strongest prognostic predictors in patients with intracerebral hemorrhage (ICH). This study aims to determine differences in imaging and clinical factors affecting survival in patients with lobar vs. deep ICH.MethodPatients with spontaneous supratentorial ICH residing in Skåne county registered in the Swedish Stro
The most common cause of death in pediatric cancer patients is a treatment-resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanisms behind metastatic spread in pediatric tumors remain largely unexplored. We conducted whole-genome copy number profiling on 171 primary tumor and metastases s
In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release o
Gas in Scattering Media Absorption Spectroscopy (GASMAS) is a near-infrared (IR) optical spectroscopy technique showing great potential in the continuous, non-invasive monitoring of the lungs. While the feasibility of GASMAS has been proven in neonatal lung studies, applying the technique to older children and adults is challenging. The increased tissue thickness strongly attenuates the signal, ne
Our current patterns of resource use have serious impact on the environment and are affecting our chances to future welfare. In this context, circular economy practices emerge as essential. Circular economy focuses on maximizing resource efficiency through reuse, repair, recycling, and product longevity—ultimately minimizing waste and reducing reliance on virgin materials. My dissertation presents
The extensive use of neonicotinoids has raised concerns about their impact on pollinators like hoverflies, which are vital for pollination and ecosystem health. This study develops and validates a green extraction method using Supercritical Fluid Extraction (SFE), coupled with HPLC (High Performance Liquid Chromatography) - MS/MS (Mass Spectrometry) for selective analysis. SFE was employed as a m
The dairy industry faces increasing demand for enhanced productivity, sustainability, and innovation. Artificial Intelligence (AI) has emerged as a transformative tool capable of addressing these challenges by enabling data-driven decision-making across the dairy supply chain. AI integrates machine learning (ML), big data analytics (DA), and predictive algorithms (PA) to optimize processes, improv
Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We
Industries across the globe are making arduous efforts to mitigate emissions and use greener ways of transporting goods and delivering services. The supply chain includes all the activities which involve producing, transporting, and distributing goods and services, contributing to a major portion of worldwide emissions. Road transport contributes majorly to emissions; therefore, focusing on net-ze
Fuel cell electric vehicles (FCEVs) are gaining global attention as a sustainable transportation solution, yet their adoption in emerging South Asian economies remains limited. This study addresses the research gap by identifying and prioritizing barriers to FCEV adoption in India, Pakistan, and Bangladesh, regions underrepresented in existing literature. A hybrid methodology integrating Explorato
Urban expansion has led to ever increasing noise and light pollution, which impairs the audio-visual perception of wild animals and drives changes in key activities and behaviours. Nocturnal predators may be especially affected in detecting prey, with potentially dramatic consequences for their fitness. However, the combined effects of noise and light pollution on predator performance are still mo
