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Cost-effectiveness of adding a non-invasive acoustic rule-out test in the evaluation of patients with symptoms suggestive of coronary artery disease : Rationale and design of the prospective, randomised, controlled, parallel-group multicenter FILTER-SCAD trial

Most patients with symptoms suggestive of chronic coronary syndrome (CCS) have no obstructive coronary artery disease (CAD) and better selection of patients to be referred for diagnostic tests is needed. The CAD-score is a non-invasive acoustic measure that, when added to pretest probability of CAD, has shown good rule-out capabilities. We aimed to test whether implementation of CAD-score in clini

Dorsal landmark navigation in a Neotropical nocturnal bee

Bees, ants, and wasps are well known to visually navigate when traveling between their nests and foraging sites. When leaving their nest, landmarks in the vicinity are memorized and used upon return to locate the nest entrance.1,2 The Neotropical nocturnal sweat bee Megalopta genalis navigates under the forest canopy at light intensities ten times dimmer than starlight.3 Despite these dim conditio

Unlocking the health system barriers to maximise the uptake and utilisation of molecular diagnostics in low-income and middle-income country setting

Background Early access to diagnosis is crucial for effective management of any disease including tuberculosis (TB). We investigated the barriers and opportunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) and Line Probe Assay (LPA

Non-attracting regions of local minima in deep and wide neural networks

Understanding the loss surface of neural networks is essential for the design of models with predictable performance and their success in applications. Experimental results suggest that sufficiently deep and wide neural networks are not negatively impacted by suboptimal local minima. Despite recent progress, the reason for this outcome is not fully understood. Could deep networks have very few, if

Berättelser och koalitioner i offentlig sektorsinnovationsarbete

Mot bakgrund av ett förändringstryck på offentlig sektor lanseras i dag flera innovationer för organisatorisk förändring. I det här kapitlet analyseras hur aktörerna som är involverade i dessa processer konstruerar, reproducerar och saluför förändringsidéer genom berättelser om offentlig sektors förnyelse –men också hur berättelserna knyter aktörerna samman och skapar nya roller och koalitioner.

A global metagenomic map of urban microbiomes and antimicrobial resistance

We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria

Population genetic considerations for using biobanks as international resources in the pandemic era and beyond

The past years have seen the rise of genomic biobanks and mega-scale meta-analysis of genomic data, which promises to reveal the genetic underpinnings of health and disease. However, the over-representation of Europeans in genomic studies not only limits the global understanding of disease risk but also inhibits viable research into the genomic differences between carriers and patients. Whilst the

Cooperative event-based rigid formation control

This article discusses cooperative stabilization control of rigid formations via an event-based approach. We first design a centralized event-based formation control system, in which a central event controller determines the next triggering time and broadcasts the event signal to all the agents for control input update. We then build on this approach to propose a distributed event control strategy

aYChr-DB : a database of ancient human Y haplogroups

Ancient Y-Chromosomal DNA is an invaluable tool for dating and discerning the origins of migration routes and demographic processes that occurred thousands of years ago. Driven by the adoption of high-throughput sequencing and capture enrichment methods in paleogenomics, the number of published ancient genomes has nearly quadrupled within the last three years (2018-2020). Whereas ancient mtDNA hap

Service quality in social media communication of NPOs : The moderating effect of channel choice

Social media communication is attractive for non-profit organizations (NPOs); however, the channels of social media are not homogeneous; a factor not sufficiently considered by empirical research. We address this gap by looking into the moderating effect of social media channel choice on the impact of brand trust on process and outcome quality. By surveying 174 customers of an Austrian NPO, we ana

Comparing the Clinical Utility and Diagnostic Performance of Cerebrospinal Fluid P-Tau181, P-Tau217 and P-Tau231 Assays

BACKGROUND AND OBJECTIVES: Phosphorylated tau (P-tau) in cerebrospinal fluid (CSF) is considered an important biomarker in Alzheimer's disease (AD) and has been incorporated in recent diagnostic criteria. Several variants exist, including P-tau at threonines 181 (P-tau181), 217 (P-tau217) and 231 (P-tau231). However, no studies have compared their diagnostic performance or association to amyloid-β

Empowering industry 4.0 and autonomous drone scouting use cases through 5G-DIVE solution

The 5G Edge Intelligence for Vertical Experimentation (5G-DIVE) project aims at demonstrating the technical merits and business value proposition of 5G technologies in two vertical pilots, namely the Industry 4.0 (I4.0) and Autonomous Drones Scout (ADS) pilots. This paper presents an overview of the overall 5G-DIVE solution and reports the results of the initial validation campaign of the selected

DEEP : A Vertical-Oriented Intelligent and Automated Platform for the Edge and Fog

The fifth generation (5G) of mobile communications introduces improvements on many fronts when compared to its previous generations. Besides the performance enhancements and new advances in radio technologies, it also integrates other technological domains, such as cloud-to-things continuum and artificial intelligence. In this work, the 5G-DIVE Elastic Edge Platform (DEEP) is proposed as the linki

Potential role of an athlete-focused echocardiogram in sports eligibility

Sudden cardiac death (SCD) of an athlete is a rare but tragic event and sport activity might play a trigger role in athletes with underlying structural or electrical heart diseases. Preparticipation screenings (PPs) have been conceived for the potential to prevent SCD in young athletes by early identification of cardiac diseases. The European Society of Cardiology protocol for PPs includes history

Breaking inversion symmetry by protonation : Experimental and theoretical NEXAFS study of the diazynium ion, N2H+

As an example of symmetry breaking in NEXAFS spectra of protonated species we present a high resolution NEXAFS spectrum of protonated dinitrogen, the diazynium ion N2H+. By ab initio calculations we show that the spectrum consists of a superposition of two nitrogen 1s absorption spectra, each including a π∗ band, and a nitrogen 1s to H+ charge transfer band followed by a weak irregular progression