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Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic inflammation induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of hypothalamic neuroinflammation and gliosis in mice fed a f

Background Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients. Methods This was a secondary analysis

Ledarskap har beskrivits som ett undflyende fenomen – en (positiv) lösning som kan kopplas till nästintill alla problem, men är svårt att fånga när det händer. Karisma, transformation och extraordinärisering utgör synsätt på ledarskap där särskilda individer tillskrivs extraordinära egenskaper, men de har inte fångat hur detta görs i vardagliga interaktioner. Ledarskap som praktik och ledarskap i Leadership has been described as a disappearing phenomenon – a (positive) solution that can be attached to almost any problem, yet it is difficult to capture as it happens. Charisma, transformation, and extra-ordinarization are perspectives on leadership where certain individuals are ascribed extraordinary qualities, but this is not captured analytically in everyday interactions. However, Leadersh

A biorefinery can operate with various plant materials as feed stock, (in contrast to fossil-based oil refineries). It has been defined by the International Energy Agency, Task 42, as “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (biofuels, power, heat)”. One of the challenges in operating large-scale facilities is that

Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se < 70 μg/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR < 0.7 of creatinine-based

Introduction: Umbilical cord blood measurement is the gold standard of evaluating neonatal metabolic status at birth. Dual sampling of cord blood vessels is clinical routine, yet the long-term value of venoarterial differences(ΔpH) is undetermined. The objective was to investigate the association of ΔpH, to long-term mortality and morbidity up to 20 years.Material and methods: This was a retrospecIntroductionUmbilical cord blood measurement is the gold standard of evaluating neonatal metabolic status at birth. Dual sampling of cord blood vessels is clinical routine, yet the long-term value of venoarterial differences (ΔpH) is undetermined. The objective was to investigate the association of ΔpH, to long-term mortality and morbidity up to 20 years.Material and methodsThis was a retrospectiv

Background: The prevalence of mental health problems is increasing, placing growing pressure on mental healthservices to provide care that is meaningful, accessible, and supportive for those who require it. However, currentpractices often do not fully meet individuals’ needs for person-centred, recovery-oriented, and integrated care andsupport. As these care and support models are being introduced

Global water scarcity requires innovative treatment solutions. This presentation explores three membrane-based concepts advancing from idea to pilot scale: stormwater harvesting with micro-/ultrafiltration (MF/UF), direct membrane filtration (DMF) for wastewater treatment, and a hybrid forward osmosis (FO), membrane distillation (MD), and nanofiltration (NF) system for seawater desalination.The EU

Paratransit services support individuals with limited mobility by providing access to healthcare, errands, and social activities. While designed to be enabling, these services impose temporal demands that require the user’s active engagement, such as booking in time and coordinating with other support services. This study explores how older users experience and manage the temporal dimensions of SwParatransit services support individuals with limited mobility by providing access to healthcare, errands, and social activities. While designed to be enabling, these services impose temporal demands that require the user’s active engagement, such as booking in time and coordinating with other support services. This study explores how older users experience and manage the temporal dimensions of Sw

Aims: In a co-twin control design, we aimed to examine whether individuals who initiate metformin treatment have an altered risk of incident diagnosis of osteoarthritis (OA), for up to 11 years after starting the treatment, compared with their non-treated co-twin. Methods: In all twin pairs different for metformin treatment (N=1 261 pairs) and all eligible twins/singletons (N=52 341) aged 35–75 ye

Despite frequent use of conodonts as an archive for seawater 87Sr/86Sr, available diagenetic screening tools are inconsistent predictors of primary seawater 87Sr/86Sr preservation. Here, we attempt to isolate variables affecting the preservation of seawater 87Sr/86Sr in conodonts. We present new Middle–Late Ordovician (∼470–450 Ma) conodont 87Sr/86Sr from mid-paleolatitude (30–45°S) carbonate succ

Background: We aimed to investigate if early life marine n-3 fatty acids and fish intake, and fatty acid desaturase (FADS) genetic variants, were associated with later risk of celiac disease (CeD).Methods: Among 85,244 children in the prospective Norwegian Mother, Father, and Child Cohort Study, fish and marine fatty acid intakes were estimated from questionnaires to mothers during pregnancy, and

ObjectiveTo determine whether the genetic disorder severe α1-antitrypsin deficiency, which has a known association with increased risk for development of lung and liver diseases, is also associated with increased risk for development of gastrointestinal diseases.Patients and MethodsWe conducted a national, longitudinal, registry-based study of individuals with severe α1-antitrypsin deficiency (phe

Background: Precision prevention involves tailoring interventions to the unique characteristics of a group or individual to maximize their effectiveness. In this study, we examined the role of participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain (GWG). Methods: We searched Medline, Embase, and PubMed, from inception up to March 2025, to id

Background: Helicobacter pylori (Hp) and its virulence factor Cytotoxin-associated gene A (CagA) have been linked to myocardial infarction (MI), but the mechanisms are unknown. This study aims to test if Hp infection and CagA are associated with pre-specified inflammatory and vascular biomarkers in patients with MI and to explore whether a broader biomarker panel can predict infection. Furthermore

Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th

Background and aims: We examined whether the excess cardiovascular disease (CVD) risk among adults with steatotic liver disease (SLD) subtypes could be reduced or eliminated through joint control of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) [Lp(a)], and high-sensitivity C-reactive protein (hs-CRP). Methods and results: This prospective cohort study included 291,995 participants f

Background: Evidence on the association between systemic glucocorticoid use and colorectal cancer (CRC) risk is limited. This study aimed to determine whether systemic glucocorticoid use is associated with an increased risk of overall CRC (diagnosed at any age) and early-onset CRC (EOCRC; diagnosed before 50 years of age). Methods: A nationwide cohort study (follow-up: 2005–2018) was conducted usi