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BackgroundOrthostatic hypotension (OH) occurs when blood pressure regulation fails. The underlying molecular mechanism of OH remain largely unexplored. Endostatin is a biologically active molecule cleaved by matrix metalloproteinases, elastases and cathepsins from collagen XVIII in the extracellular matrix and inhibits angiogenesis. Circulating levels of endostatin have been proposed to be involve
Background: There are contradictory research findings regarding whether individuals with Autism Spectrum Disorders (ASDs) are more or less likely to commit crimes. The aims of the current study were to: (1) Describe psychiatric and crime-related characteristics of a large group of offenders with ASD who had undergone a Forensic Psychiatric Investigation (FPI). (2) Identify clinical subgroups among
BACKGROUND: Oncological outcome after radical radiotherapy (RRT) combined with neoadjuvant and adjuvant androgen suppression therapy (AST) may differ according to type of AST. The aim of this nationwide register-based study was to investigate risk of prostate cancer (Pca) death after different neoadjuvant and adjuvant ASTs; (i) bicalutamide, (ii) gonadotropin-releasing hormone agonists (GnRH) or (
Aims/hypothesis: Roux-en-Y gastric bypass surgery (RYGB) frequently results in remission of type 2 diabetes as well as exaggerated secretion of glucagon-like peptide-1 (GLP-1). Here, we assessed RYGB-induced transcriptomic alterations in the small intestine and investigated how they were related to the regulation of GLP-1 production and secretion in vitro and in vivo. Methods: Human jejunal sample
Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions part
Greater central artery stiffness is observed in people with type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery s
Pentachlorophenol (PCP) is a commonly found recalcitrant and toxic groundwater contaminant that resists degradation, bioaccumulates, and has a potential for long-range environmental transport. Taking proper actions to deal with the pollutant accounting for the life cycle consequences requires a better understanding of its behavior in the subsurface. We recognize the huge potential for enhancing de
Orthostatic hypotension (OH) is associated with increased total mortality but contribution of specific death causes has not been thoroughly explored. In this prospective study, authors followed up 32,068 individuals without baseline history of cancer or cardiovascular disease (69% men; mean age, 46 years; range, 26-61 years) over a period of 24 years. Hazard ratios (HRs) for total and cause-specif
Male cancer survivors (MCS) are at risk of suffering from impaired fertility. Male fertility is dependant on sperm DNA quality. The Sperm Chromatin Structure Assay (SCSA) reflects the proportion of sperm with poor DNA, the DNA fragmentation index, DFI. A high DFI indicates reduced in vivo fertility and the need of ICSI (Intracytoplasmic sperm injection) to achieve pregnancy. A concern with ICSI, i
The ability to understand and communicate about the actions of others is a fundamental aspect of our daily activity. How can we talk about what others are doing? What qualities do different actions have such that they cause us to see them as being different or similar? What is the connection between what we see and the development of concepts and words or expressions for the things that we see? To
Future anthropogenic climate change is likely to increase the air temperature (T a ) across Europe and increase the frequency, duration and magnitude of severe heat stress events. Heat stress events are generally associated with clear-sky conditions and high T a , which give rise to high radiant heat load, i.e. mean radiant temperature (T mrt ). In urban environments, T mrt is strongly influenced
The effect of climate change on tree growth in boreal forests is likely mediated by local climate conditions and species-specific responses that vary according to differences in traits. Here, we assess species-specific tree growth responses to climate along gradients of mean annual temperature and soil moisture. We assessed growth-climate relationships by using tree-ring width data in Norway spruc
Background Anorexia nervosa is associated with high personal and financial costs for sufferers, carers and society in general, but little is known about the long-term health economic burden. Aims To examine healthcare utilisation, social assistance, sick leave and disability pension in individuals with anorexia nervosa over a period of 30 years. Method Fifty-one individuals with adolescent-onset a
AbstractGiant Cell Arteritis (GCA) is the most common vasculitis in adults among people in the western world. The pathogenesis and etiology are not fully understood.In Study I, we investigated potential predictors for developing GCA, i.e. Body Mass Index (BMI), smoking and hormone-related factors, in a nested case control study. We identified cases and matched controls (4/case) who previously had
Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepress
