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Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy techniques have been used extensively for metabolite profiling. Although combining these two analytical modalities has the potential of enhancing metabolite coverage, such studies are sparse. In this study we test the hypothesis that combining the metabolic information obtained using liquid chromatography (LC) MS and 1H NMR s

Energy balance closure is an important feature in studies of ecosystem exchanges of energy and greenhouse gases using the eddy covariance method. Previous analyses show that this is still a problem with imbalances in the order of 0.6–0.7 to full closure (for only a few sites). It has been suggested that mesoscale transport processes that are not captured by the eddy covariance measurements are the

Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), force

Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. Mortality rates from 3-33 % and varying morbidity have been reported, most commonly using the Extended Glasgow Outcome Scale (eGOS). The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing c

Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. The circulating levels of its precursor, pro-NT, predicts the presence and development of metabolic and cardiovascular dise

Objective Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format. Design A pilot, single-blind, parallel

Den undersökning och intervjubaserade mixed metods-forskningen som presenteras i denna sammanläggningsavhandling utforskar hur flygtekniker i Sverige, Norge och Portugal upplever att arbeta under den vertikala kedjan av hård och mjuk lagstiftning som utgör Europeiska Unionens reglering av denna sektor. Genom att fokusera på händelserapportering och certifiering av att flygplan kan tas i drift, som

Background: Molecular signatures in prostate cancer (PCa) tissue can provide useful prognostic information to improve the understanding of a patient's risk of harbouring aggressive disease. Objective: To develop and validate a gene signature that adds independent prognostic information to clinical parameters for better treatment decisions and patient management. Design, setting, and participants:

Numerous risks threaten modern society. Some are new, while others have existed since the beginning of time, but none have been governed on a societal level since their inception. Despite the abundance of literature addressing the governance of various risks, the processes by which they become governable in the first place have gotten little attention. As a result, this paper aims to improve our k

Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly l

Accurate monitoring of glaciers’ extents and their dynamics is essential for improving our understanding of the impacts of climate and environmental changes in cold regions. The satellite-based Normalized Difference Snow Index (NDSI) has been widely used for mapping snow cover and glaciers around the globe. However, mapping glaciers in snow-covered areas using existing indices remains a challengin

Recent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While the link between systemic metabolism and atherosclerosis is well established, the implications of altered metabolism in the artery wall are less understood. Pyruvate dehydrogenase kinase (PDK)-dependent inhibition of pyruvate dehydrogenase (PDH) has been identi

Soft skills are becoming equally crucial as hard skills in today's labour market. In contrast to hard skills which are teachable typically through formal education, soft skills are non-technical and interpersonal, allowing individuals to be able to find and succeed in their studies, jobs, and professional life. Despite the increasing emphasis on soft skills, many university students are either una

Background: Brief Admission by self-referral is a preventive intervention here intended for individuals who recurrently self-harm and have a history of contact with emergency psychiatric services. Individuals with access to Brief Admission are empowered to self-admit to inpatient care for up to three days per stay and are encouraged to do so before experiencing crisis. Brief Admission was implemen

Purpose: In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866). Methods: We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to

Reception – hospitality and hostilityMarcus Knutagård and Arne KristiansenSchool of Social Work, Lund UniversityThe aim of this paper is to analyse the practice of reception of newly arrived migrants. The paper is part of an ongoing project Scanian homes: Reception, settlement or rejection – homelessness policies and strategies for refugee settlement. The aim of the project is to investigate the pReception – hospitality and hostilityMarcus Knutagård and Arne KristiansenSchool of Social Work, Lund UniversityThe aim of this paper is to analyse the practice of reception of newly arrived migrants. The paper is part of an ongoing project Scanian homes: Reception, settlement or rejection – homelessness policies and strategies for refugee settlement. The aim of the project is to investigate the p