Background and aims After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lip

Celiac disease is associated with the HLA-DR3-DQA1*05:01-DQB1*02:01 and DR4-DQA1*03:01-DQB1*03:02 haplotypes. In addition, there are currently over 40 non-HLA loci associated with celiac disease. This study extends previous analyses on different HLA haplotypes in celiac disease using next generation targeted sequencing. Included were 143 patients with celiac disease and 135 non-celiac disease cont

High blood glucose triggers the release of insulin from pancreatic beta cells, but if chronic, causes cellular stress, partly due to impaired Ca2+ homeostasis. Ca2+ influx is controlled by voltage-gated calcium channels (CaV) and high density of CaV in the plasma membrane could lead to Ca2+ overload. Trafficking of the pore-forming CaVα1 subunit to the plasma membrane is regulated by auxiliary sub

For the assessment of value of new therapies in healthcare, Health Technology Assessment (HTA) agencies often review the cost per quality-adjusted life-year (QALY) gained. Some HTA agencies accept a higher cost per QALY gained when treatment is aimed at prolonging survival for patients with a short expected remaining lifetime, a so-called end-of-life (EoL) premium. The objective of this study is t

Conventional views of the police support a norm of emotion management. Aspiring police officers are taught not to show pain or fear and to display an image of control and assertion. If failing to convey such emotions officers might be considered too weak or simply not “man enough” for the job. This is also the case concerning border guarding and border police conduct. This study draws on data gath

The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (C

The development of cities is increasingly threatened by a worldwide water crisis. Urban water services (including drinking water, sanitation and drainage) are facing complex and multiple pressures, which are becoming increasingly frequent and severe. These pressures include floods, and the depletion, pollution and degradation of water resources and their associated ecosystems. These diverse pressu

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from t

According to the traditional view, the relation between morphology and syntax is the following: while morphology builds up word forms—typically by combining roots with other roots and with affixes, but also by applying other operations to them, syntax takes fully inflected words as input and combines them into phrases and sentences. The division of labour between morphology and syntax is thus perf

Today, the demand for shorter lead times, shorter production runs and more diversified products is a general market trend, which puts pressure on logistics systems. When adapting to this trend, agile manufacturing becomes increasingly important. Flexible printing activities, in particular, are needed when products and packaging designs increasingly are to be adapted for niche markets. This study s

Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/

AIM: The aim of this study was to investigate to what extent individual-based extended information given to mothers from city parts of low education can improve precautions taken by them to prevent burn and scald injuries involving young children in the home and further to compare the results with a group of mothers who had not received extended information. METHODS: This intervention study, with

Gifts have been given and received in all eras and societies; gifts are part of a universal human exchange. The importance of creating and sustaining social bonds with the help of gifts is widely acknowledged by social scientists, not only from anthropological but also from economic, sociological, and political science perspectives. Contemporary anti-corruption campaigns, however, have gifts to be

In order to meet the unprecedented challenge of feeding an increasing population while curbing associated environmental impacts a fundamental change in the current food system is required. Such a shift needs an active facilitator who could set and implement the sustainability agenda in the food supply chain. Recently, it has been argued that retailers might become a vital agent of change towards s