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Environmental exposure to noise and particle matter (PM) are risk factors for cardiovascular disease (CVD). Although there are often higher levels in occupational settings, little is known about noise and particle exposures at work and CVD risks. We investigated occupational noise and particle exposures and acute effects on pulse rate and blood pressure. 46 active, non-smoking, male construction w
Adipocyte dysfunction is a crucial driver of insulin resistance and type 2 diabetes. We identified EH domain-containing protein 2 (EHD2) as one of the most highly upregulated genes at the early stage of adipose tissue expansion. EHD2 is a dynamin-related ATPase influencing several cellular processes, including membrane recycling, caveolae dynamics and lipid metabolism. Here, we investigated the ro
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur during prophase of the first meiotic division. Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic cross
The aim of this presentation is to examine the complex reception history of Astrid Lindgren's classic children's book “Pippi Longstocking” in the GDR based on the appearance and paper quality of the various editions. “Pippi Longstockning” was published in two different editions in 1975 and 1988 by the East Berlin Children's Book Publishing House (Kinderbuchverlag Berlin). The differences between t
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc
Migratory routes and remote wintering quarters in birds are often species and even population specific. It has been known for decades that songbirds mainly migrate solitarily, and that the migration direction is genetically controlled. Yet, the underlying genetic mechanisms remain unknown. To investigate the genetic basis of migration direction, we track genotyped willow warblers Phylloscopus troc
Purpose: This research explores how status is manifested within the foodie culture. More specifically, we explored how foodies claim status and express inconspicuous meanings through their food consumption practices. Methodology: A hermeneutical epistemology approach was pursued, with the use of Interpretivism to generate insights into the foodie lived experience. A constructionist ontological pe
Populärvetenskaplig sammanfattning: Höga kadmiumkoncentrationer har uppmätts i mark, grundvatten och biota kring St.Olof, SÖ Skåne. Lokala geologiska förhållanden verkar spela en stor roll för den naturliga bakgrundshaltens variation. Området täcks av en basal utsmältningsmorän som sällan överstiger 10 meter i mäktighet och vars bergartssammansättning domineras av lokalt material. Tre lokaler vald
Populärvetenskaplig sammanfattning: Conodonter är mikroskopiska tänder från det s.k. conodontdjuret, ett fiskliknande djur som är utdött sedan juraperioden. Dessa kan hittas i stora mängder i vissa sedimentära bergarter som t. ex. de kalkhaltiga sediment som utgör Köpings klint på Öland där mina prover togs av dr. Stig M. Bergström och dr. Jan Bergström år 1960. Undersökningen behandlar conodonter
Populärvetenskaplig sammanfattning: När Sveriges Geologiska Undersökning (SGU) karterade nordöstra Skåne påträffades dels kalksediment i ett annars gnejsdominerat område, dels ett gyttjeliknande manganförande material i en husbehovstäkt i Broestorp, 2 km SSV om Sibbhult, NO Skåne. Syftet med min undersökning var att dokumentera och bestämma bildningen för moränskärningarna i täkten, utbredningen a
Vitamin D and its analogues are fat-soluble vitamins that carry out important functions in human and animal organisms. Many studies have pointed out the relationship between the deficiency of these substances and the development of both skeletal-and extra-skeletal diseases. Although vitamin D is fundamentally derived from the bio-transformation of its precursor, 7-dehydrocholesterol, through the a
As institutional forms of political engagement continue to decline, participation in protests steadily become more common. These trends are particularly strong among younger citizens. Previous research indicates that social factors can explain participation in political protests, and that younger citizens’ participation in protests is more affected by social ties than older people’s participation.
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified
Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets using human loss-of-function variants. First, even essential genes, in which loss-of-function variants
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with
