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The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “stimulus-secretion coupling”. The core of stimulus-secretion coupling is a process which generates electrical activity in response to glucose uptake and causes Ca2+ oscillation for triggering exocytosis of insulin-containing secretory granules. Prior to exocytosis, the secretory granules are mobili
Habitat preferences and foraging strategies affect population-level space use and are therefore crucial to understanding population change and implementing spatial conservation and management actions. We investigated the breeding season habitat preference and foraging site fidelity of the under-studied and threatened, Baltic Sea population of Caspian Terns (Hydroprogne caspia). Using GPS devices,
Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of
The exact spatial and temporal behaviour of rapid climate shifts during the Last Glacial– Interglacial Transition are still not entirely understood. In order to investigate these events, it is necessary to have detailed palaeoenvironmental reconstructions at geographically spread study sites combined with reliable correlations between them. Tephrochronology, i.e., using volcanic ash deposits in ge
We know that informal networks explain differences in career success. Historical differences in business careers of men and women have frequently been explained with differences in informal networks. We also know that corporations tend to recruit future leaders and professionals from highly ranked business schools, and that important social networks form among the students there. However, it is no
As climate-related issues are important and concern all aspects of the built environment, there is a need to better understand the motives underlying household recycling behavior. The purpose of the present study is twofold: to investigate factors important for explaining the recycling behavior of young people and to explore respondents’ own ideas regarding barriers to recycling. This paper report
Background: In problem gambling, normative personalized feedback interventions have demonstrated promising effects. Given the widespread increase in online gambling in recent years, internet-delivered normative feedback may serve as a promising intervention. This study aimed to examine whether such an intervention, delivered by a gambling operator and aiming to help problem gamblers decrease their
There is a knowledge gap about nurses’ use of social media in relation to and during the COVID-19 pandemic, which demands the upholding of a physical distance to other people, including patients and their relatives. The study aims to explore how nurses in the Scandinavian countries used social media for professional purposes in relation to the first 15 months of the COVID-19 pandemic. Qualitative,
Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unknown. We hypothesized that the protease cathepsin G (CG) may participate in degrading lubricin in sy
Large carnivores elicit strong emotional reactions, which could influence consensus or social conflicts between persons promoting wildlife conservation and people who suffer from its negative consequences. Interventions to prevent carnivore attacks on domestic animals are intended to promote coexistence between people and carnivores, but could fail to mitigate fear and social conflicts if emotions
We investigate how early exposure to parental externalizing behaviors (EB) may contribute to development of alcohol use disorders (AUD) in young adulthood, testing a developmental cascade model focused on competencies in three domains (academic, conduct, and work) in adolescence and emerging adulthood, and examining whether high parental education can buffer negative effects of parental EB and oth
This article explores the paradox of corporations using social and environmental justice concerns to market products that are themselves made in conditions of environmental and social injustice, most often in the Global South. The effects of the fashion industry on people is two-pronged: 1) the unsafe and exploitative conditions under which many garment workers operate, and 2) the severe and harmf
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models (HMMs) and its variants are a class of models
