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The combination of solar heat and ground-source heat pumps in dwellings gives opportunities for optimising the use of renewable energy sources and minimize the share of bought energy. Solar collectors in the system may give advantages for the operational conditions both for the solar collectors and for the heat pump. The aim of this project was to analyse different variables such as energy demand,
The enlargement of the European Union provides opportunities for members to be mobile in seeking various forms of permanent and non-permanent employment, particularly temporary work and contract labour. These changing conditions require quick reactions, overcoming soft issues such as language barriers and coping with culture clashes and political issues that could create problems for the worker. W
Consumer awareness regarding food production and food content is steadily growing. An alternative to the current model of global food chains is local production of food and local sales of food at farmers’ markets. This chapter assesses the social and economic benefits of farmers’ markets both for the farmers taking part in the markets and for the consumers purchasing the products on sale. The deve
Bioethical government advisory committees have profound influence on political decision-making on gene technology issues, concerning not only patients with genetically related diseases, but also, potentially, the whole society. • Decision-making on issues concerning all society should be democratically legitimate in all aspects, including the work of government advisory committees. • Democratic le
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the prese
Most microlevel studies in the social sciences have focused on the impact of different measured variables. While some studies have also dealt with unobserved variation, it has usually only been controlled for to perfect the estimates of the observables. In this article, the authors applied a modified version of a recently developed method designed to quantify the effect of unobserved variation in
The progression of diabetes is accompanied by increasing demand to the beta-cells to produce and secrete more insulin, requiring complex beta-cell adaptations. Functionally-active and ubiquitous non-coding RNAs (ncRNAs) have the capacity to take part in such adaptations as they have been shown to be key regulatory molecules in various biological processes. In the pancreatic islets, the function of
Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the majo
Type 2 diabetes (T2D) develops due to insulin resistance and impaired insulin secretion, predominantly in genetically predisposed subjects exposed to nongenetic risk factors like obesity, physical inactivity and ageing. Emerging data suggest that epigenetics also play a key role in the pathogenesis of T2D. Genome-wide studies have identified altered DNA methylation patterns in pancreatic islets, s
Purpose – The purpose of this paper is to look more closely at the residents’ attitude to individual heat metering and charging systems (IMC) of multi-family dwellings in residential properties, and to evaluate the tenant’s perception of IMC and how it may affect the continued expansion of such systems. Design/methodology/approach – The research in this paper is based on a questionnaire and interv
Sustainability science needs approaches that allow for the integration of knowledge across disciplines and scales. This paper suggests an approach to conceptualize problems of unsustainability by embedding the Drivers-Pressure-State-Impact-Response (DPSIR) scheme within a multi-level institutional framework represented by Hagerstrand's system of nested domains. The proposed taxonomy helps to decip
The analytical framework of regional innovation systems highlights the systemic nature of regional economies and the need for policy coordination within regions. Coordination presupposes an understanding of the underlying problems that may act as barriers to regional development. Three generic problems facing regions are: lack of resources (e.g. human and financial capital), negative lock-in (e.g.
