Filtyp
The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on th
Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). This was discovered in the early 1960's when a screening program was initiated by the National Cancer Institute (NCI) in the US, with the aim to find new natural products
Melanin is an epidermal pigment commonly known to give darker skin coloration under sun exposure. It is also present in the hair, eyes, inner ear and brain. The first function of epidermis melanin is believed to be photoprotective against harmful ultraviolet (UV) light, but the recent increase of skin cancer correlated to an increase of sun exposure questions the properties of melanin. Its presenc
The outcomes of 20 patients participating in occupational group therapy at a psychiatric outpatient unit were explored and related to perceptions of the ward atmosphere and the treatment process. The outcome variables - psychiatric symptoms, global mental health, quality of life, and occupational functioning - were measured at admission, at discharge, and 1 year after discharge. The ward atmospher
A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. The convenient experimental procedure allowed the
Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). Numerous long-lasting hypoglycemic reactions, which have sometimes been fatal, have been reported and have been difficult to reconsile with an allegedly short elimina
The research focus in this dissertation has been on success in selling as created in the seller and buyer interaction on and between macro-, meso- and micro levels. Success seen as a value has consequences for the exchange process, since it affects the actor's action in the seller and buyer interaction on different levels in companies. The study of value is limited to success in selling as a value
In this thesis, spectroscopic studies of quantum wells (QWs), quantum wires (QWRs) and quantum dots (QDs) in III-V semiconductors are presented. The electronic structure of these low-dimensional structures have been studied by absorption, photocurrent, electroreflectance, photoluminescence (PL), and photoluminescence excitation (PLE) spectroscopy. The band alignment of GaAs pseudomorphically grow
Magnetic relaxation dispersion measurements have been performed on aqueous protein solutions to study the dynamics of waters in the proton transport channel of bacteriorhodopsin and the self-association of the proteins BPTI, lysozyme and beta-lactoglobulin. The measurements have focused on the bulk relaxation rates, R1 and R2, of three water nuclei 1H, 2H and 17O that are coupled to the protein en
Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity. Early recognition of vascular changes, both structural and functional, may help to identify individuals at risk for CVD. Using modern ultrasound techniques – the echo-tracking technique for assessment of stiffness in large arteries and flow-mediated dilatation of the brachial artery as an indicator of endothelial
Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. Despite tremendous advances in all fields
Antibiotic resistance is now a large threat with worldwide agreement that we will fall into a post-antibiotic era unless there is suitable treatment alternatives discovered. In recent years, chronic wounds have become a major burden on society and treatment is complicated. Honey has been widely used as a topical treatment for wounds yet there is much discourse between studies examining its effect
This dissertation analyzes the work on universal morality by the Swiss theologian Hans Küng. According to Küng, a universal morality can be formed out of the world's religions that can reconcile ideological, cultural and religious differences. This morality can then form the basis for international policy and politics and guarantee that relations among states are peaceful. Küng's project focuses
The overall aim of this study is to describe a number of different uses of the French "seul" and "seulement", and to account for the observed differences within a generative framework. After an introductory chapter, chapters two and three present a survey of earlier studies. The fourth chapter concerns an empirical study of authentic occurrences of "seul" and seulement", drawn from the press. The
The life cycle of electronic products is associated with significant environmental impacts. Compared to many other products, the production of electronics and in particular semiconductors is resource intensive and generates a number of highly toxic waste streams in manufacturing and post-consumer stages of product life cycle. Electronics manufacturing industry has been successful in reducing envir
The overiding aim of this study is to promote an increace in the knowledge regarding school children´s learning and meaning construction, whereby teachers attempt to exceed traditional ways of learning by combining asthetics and rationality as an integration of the learning process. The aim is to describe and interpret that which occurs in discussions between teachers and the children, when the ch
In a flexible real-time system, the constraints in available CPU time and memory lead to resource management problems, which must be handled carefully in order to maximize quality of service while avoiding overload. Managing CPU time -- scheduling -- is well studied and dynamic scheduling is widely accepted in the real-time industry. In order to make safe high-level languages, like Java, practical
Members of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte
The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle
