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The extracellular matrix (ECM) is a network of macromolecules which, together with cells, forms the various tissues of all metazoan organisms. Cartilage, in contrast to most other tissues, contains relatively few cells in proportion to the volume occupied by ECM. Part of this work involves investigation of cartilage ECM for expression and secretion of proteins that are considered to be the definin

Infectious diseases constitute a major global health problem. The presenting clinical picture results from a mixture of direct toxic actions by the microbiological agent and of the immune response mounted by the host. There is often a rapid onset, which may constitute a diagnostic and therapeutic challenge, whereas in other cases an extensive investigation over a long time period can fail to ident

If Luke’s first audience understood the Gospel as a biography, what would their experience of the text have been? This book invites the reader to accompany the first readers or hearers of Luke’s Gospel and to experience the narrative about the life of Jesus alongside them. It utilises Wolfgang Iser’s theory about reading and readers and focuses on gaps and vacancies in the text. The most important

The dynamic friction process and contact surface between tool and working material in a plastic forming process is hard to describe in mathematical form and hard to monitor and control in real time. High production speed and highly optimised forming operations result in great demands on the control equipment. Especially if the influence from variations due to the tool, work material and the fricti

This study focuses on the region of Argolid in the eastern part of the Greek Peloponnese during the Roman Imperial era, taking up a variety of aspects of life there based mainly on archaeological evidence. The introduction presents the study area and the background to the study. This is followed in the next chapter by a survey of the various kinds of sites of Roman date found in the Argolid. Citie

Goodpasture disease is a prototype autoimmune disease that is characterized by a rapidly progressive glomerulonephritis, with or without lung haemorrhage, associated with autoantibodies against the glomerular basement membrane. The major antigen has previously been shown to be the non-collagenous domain of the a3 chain of type IV collagen, one of the six known a chains of type IV collagen. On aver

Life as we know it is based on cells that use proteins and RNA to carry out metabolism, self-replication, and other essential tasks. The genes that code for these molecules are encoded in DNA, and through the processes of transcription and translation the cell expresses its genes. Some proteins are transcription factors that regulate the transcription rate of genes, so genes interact and form a ge

It has long been thought that aging is accompanied by an emotional flattening. Although a different view has started to emerge recently, studies investigating psychophysiological responses in reaction to affective stimuli so far have reported an age-related reduction of the affective response. One of the main goals of this thesis was to revisit this issue by examining subjective reports, phasic he

The aim of this thesis is to enhance the overall understanding of the plasma spray process and increase control and reproducibility of the coating properties. This was performed by establishment of relationships between controllable process parameters, in-flight properties of the injected particles (velocity and temperature), and microstructure properties. The relationships were used to establish

With the main aim to test the applicability of the surface wave seismic technique Spectral Analysis of Surface Waves (SASW), used for determination of the shear stiffness (shear modulus - Gmax), four areas of applications have been studied. The four areas have been sites with natural geological conditions, sites where non destructive testing is necessary, pavement testing and multichannel testing.

Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. The miRNA expression profiles in different human cancers

Fouling is the deposit of proteins and minerals formed on equipment surfaces during the heat treatment of dairy products. The concentrations of the components and the structure of the fouling reflect the processing conditions used. The use of a higher processing temperature, e.g., ultra-high temperature (UHT) treatment, promotes a mineral-rich fouling. The fouling layer decreases the transfer of h

Contrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM con

Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ferrochelatase inserts a ferrous ion. These two enzymes have been studied in this thesis. Even though they both insert a metal ion into protoporphyrin IX the

The Late etruscan terracotta votive heads from Tessennano were found near a rural sanctuary about a hundred km to the North of Rome in 1956. Whereas the facial fronts are serially produced with moulds, the backs are handmade. By using not only the moulded and the handmade features but the raw material (clay and temper) as well, it has been possible to make suggestions as to how, when and where the

The aim of this work was to achieve surface modification of two biomedical polyurethanes and one poly(urethane urea) through the addition of small amounts of amphiphilic copolymers in solution. The matrix polymers used were the poly(ether urethane)s Pellethane 2363-80AE (P80) and 2363-75D (P75) and a poly(ether urethane urea) similar to Biomer (PUUR). The amphiphilic additives consisted of segment

Positron emission tomography (PET) is a tracer technique used for quantitative in vivo studies of physiological and biochemical processes. Because of the use of positron-emitting radionuclides such as 11-C, 13-N, 15-O and 18-F, which are isotopes of the biologically ubiquitous elements, it is possible to label radiopharmaceuticals which trace biochemical processes precisely. In order to be able to

Through the identification of a series of inscriptions, mainly datable to the Hellenistic era, a link between Aphrodite and the civic life and administration of the Greek poleis has come to light. The inscriptions in question are dedications to Aphrodite through which magistrates of various cities and varying status express their devotion to the goddess. In certain dedications, the goddess is even

The function of non-vertebrate haemoglobins (Hbs) appears more diverse than that of vertebrate Hbs, possibly reflecting the various demands to be met among their hosts. Sharing structural features with other haem proteins/enzymes, Hbs display a qualitative overlap in activities with functions extending beyond oxygen transport/storage. When subjected to oxygen deficient conditions, the obligate ae