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Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar
Cities typically treat migration and sustainability as separate policy domains. When migration is highlighted in the context of sustainability in urban destination areas, it is typically understood to have no, or at worst, negative impacts on sustainability. As a result, migration and migrants are commonly left out of sustainability policy and planning. Here, we present emerging evidence to refram
Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline
We study how inheriting parents' credit histories affects the initial credit scores, access to credit, and life cycle borrowing of young individuals entering the credit market. We establish that inherited histories significantly positively affect initial scores, which in turn are very persistent. Inherited histories only affect outcomes through initial credit scores, which then have significant pe
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acut
The intricate relationship between climate change and the building sector is characterized by a self-reinforcing loop. Rising temperatures driven by global warming will inevitably impact heating and cooling energy, while buildings simultaneously contribute significantly to carbon emissions throughout their lifecycle, further exacerbating climate change. However, current knowledge regarding the int
Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before
The ecosystem response to disturbances is a central topic in ecology, and there is growing awareness of the impacts of human-driven climate change on ecosystem stability to disturbances. Terrestrial ecosystems are increasingly exposed to more drought and rainfall events as climate change intensifies. In soils, bacteria and fungi play a key role in ecosystem functioning, yet their responses to drou
Uppsatsen analyserar inledningsvis vad Method Acting innebär. Den ryske regissören och skådespelaren Konstantin Stanislavskij utarbetade i början på förra seklet ett system vars uppgift var att utforma ett skådespeleri som bröt mot normen av, vad han tyckte var, orealistiskt spel. Med naturalismen kom kravet att teaterns uppgift var inte att försköna verkligheten utan att visa verkligheten som den
Kvantdatorer har fått mycket fokus i media de senaste åren på grund av sin potentiella förmåga att lösa problem som är för tidskrävande för att låta sig lösas på klassiska datorer. Kvantdatorer skiljer sig i grunden från dagens datorer, genom att bygga på gåtfulla kvantmekaniska egenskaper. En sådan är kvantsuperposition, som innebär att en partikel kan vara i flera kvanttillstånd samtidigt. AntagQuantum annealing provides a promising avenue for obtaining good approximate solutions to difficult optimization problems. Protein folding represents one such problem. For testing novel algorithms and technologies, simplified lattice models are well suited, as they represent considerable computational challenges despite their simplicity. One such model is the HP model, where the protein is represe
Worldwide plastic production is expected to reach an amount of 34 billion tons by 2050, and a large portion of plastic used is for single-use packaging and low-cost consumer plastic products that are discarded. It is important to have a path to a circular economy by recycling and producing locally. The following potential research questions were identified to contribute to the existing knowledge i
Purpose - The aim of this paper is to analyze Artificial Intelligence in the music industry in order to provide an indication of how Artificial Intelligence is expected to continue impacting the connection between the consumer and the brand. Design/methodology/approach - The study is based on a qualitative single case study method and it discusses how Spotify has incorporated Artificial Intellige
Command responsibility is a mode of criminal responsibility that developed mostly during the 20th century and provides the opportunity to charge military commanders and other superiors for war crimes and crimes against humanity committed by their subordinates by proving three criteria. To begin with, the commander must have exercised effective control over the subordinate, moreover the commander m
Sudan har sedan april 2023 präglats av ett brutalt inbördeskrig mellan Sudanese Armed Forces (SAF) och Rapid Support Forces (RSF), vilket resulterat i en statlig kollaps och omfattande civil fördrivning. I detta sammanhang har konfliktrelaterat sexuellt våld (CRSV) blivit särskilt framträdande. Denna uppsats analyserar hur CRSV konstrueras i tre centrala internationella rapporter från FN:s högkommSince April 2023, Sudan has been engulfed in a brutal civil war between the Sudanese Armed Forces (SAF) and the Rapid Support Forces (RSF). The conflict has triggered the collapse of state institutions and forced the displacement of millions. Amid this humanitarian crisis, conflict-related sexual violence (CRSV) has emerged as a defining and deeply troubling feature. This thesis explores how CRSV
Coherent radiation from a relativistic electron beam is a valuable way to overcome the present limitations of conventional lasers and synchrotron radiation light sources. The typical scheme has electrons, directly from a linac, in a single-pass interaction with a laser pulse in the presence of a static undulator magnetic field. We demonstrate that a storage-ring free-electron laser can also achiev
My objective has been to characterize protein-surfactant interactions in pharmaceutically relevant formulations. Thus, the behavior of selected excipients, proteins and peptides has been studied as the system in question is driven to the verge of instability in different manners; by inducing aggregation, by inducing surfactant complexation, or by inducing precipitation by increasing ionic strength
Purpose: To examine associations of prenatal biomarkers of pesticide exposure with birth size measures and length of gestation among newborns from the Infants' Environmental Health (ISA) birth cohort, Costa Rica. Methods: We included 386 singleton liveborn newborns with data on birth size measures, length of gestation, and maternal urinary biomarkers of chlorpyrifos, synthetic pyrethroids, mancoze
Harvest residue management is a key issue for the sustainability of Eucalyptus plantations established on poor soils. Soil microbial communities contribute to soil fertility by the decomposition of the organic matter (OM), but little is known about the effect of whole-tree harvesting (WTH) in comparison to stem only harvesting (SOH) on soil microbial functional diversity in Eucalyptus plantations.
