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EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly relevant. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized human oncoprotein. CIP2A promotes malignant cell grow

Laminin-211 is a major constituent of the skeletal muscle basement membrane. It stabilizes skeletal muscle and influences signal transduction events from the myomatrix to the muscle cell. Mutations in the gene encoding the α2 chain of laminin-211 lead to congenital muscular dystrophy type 1A (MDC1A), a life-threatening disease characterized by severe hypotonia, progressive muscle weakness, and joi

This paper presents a method for using subjective factors to evaluate project success. The method is based on collection of subjective measures with respect to project characteristics and project success indicators. The paper introduces a new classification scheme for assessing software projects. Further, it is illustrated how the method may be used to predict software success using subjective mea

The life and culture of the nobility in Finland in the 18-th and early 19-th centuries in Finland. Political culture and relations, everyday life an networks in Finland, Sweden and western parts of Russia. In the centre you find the families Creutz, Glansenstierna and Sprengtporten.

This study examined variability of lip movements across repetitions of the same utterance as a function of age in Swedish speakers. Subjects were 37 typically developed Swedish children and adults (19 females, 18 males, aged 5-31 yr). Lip movements were recorded during 15-20 repetitions of a short Swedish phrase using articulography, with a sampling rate of 200 Hz. After correction for head moveme

Most primary immunodeficiencies (PIDs) have overlapping signs and symptoms - presenting a challenge for diagnosis. The information available from the Internet for over 200 PIDs is scattered between numerous services and databases. Patient information has been collected in different patient registries. Several software tools have been developed in order to build the databases, expert systems and ot

Since treatment for latent cryptococcal infection (CI) before starting antiretroviral therapy (ART) reduces mortality in HIV-infected subjects, screening for cryptococcal antigen (CrAg) in blood is recommended for individuals with CD4 cell counts < 100 cells/µL in regions with high CI prevalence. We assessed CrAg screening using the lateral flow assay in HIV-infected adults eligible for ART in cen

The platelet-derived growth factor (PDGF) alpha and beta receptors undergo dimerization as a consequence of ligand binding. Depending on the PDGF isoform (PDGF-AA, -AB or -BB), homodimers or heterodimers of receptors are formed. In this study, we have used transfected porcine aortic endothelial cells, coexpressing cDNAs for the alpha receptor and the beta receptor at comparable levels, to investig

This article explores the technological choices made at the dawn of the massification of retail finance. We describe and analyze the early development of electronic banking and the foundations of the cashless society through the experiences of organizations with similar governance in two different competitive environments — Swedish and British savings banks. We document how the adoption of direct-

Abstract in UndeterminedThere is a recognized disconnect between testing research and industry practice, and more studies are needed on understanding how testing is conducted in real-world circumstances instead of demonstrating the superiority of specific methods. Recent literature indicates that testing is a cross-cutting activity that involves various organizational roles rather than the sole in