HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, derived

Weld residual stress (RS) measurements are often undertaken on test-pieces which have been Cut Out from large components, yet it remains unclear to what extent the RSs in test-pieces are representative of those present in the original component. Similarly weld mechanical performance tests are frequently undertaken on cross-weld test-pieces without a proper understanding of the level or influence o

Background: Songbirds hold great promise for biomedical, environmental and evolutionary research. A complete draft sequence of the zebra finch genome is imminent, yet a need remains for application of genomic resources within a research community traditionally focused on ethology and neurobiological methods. In response, we developed a core set of genomic tools and a novel collaborative strategy t

This contribution reviews a number of applications of the ab initio no-core shell model (NCSM) within nuclear physics and beyond. We will highlight a nuclear-structure study of the A = 12 isobar using a chiral NN + 3NF interaction. In the spirit of this workshop we will also mention the new development of the NCSM formalism to describe open channels and to approach the problem of nuclear reactions

Partitioning and mapping are important design decisions in exploiting the parallelism of programs that are to be run on systems with multiple processing elements. In this paper we introduce a fast, incremental approach for mapping dynamic dataflow programs to multiprocessor systems. We use causation traces and architecture descriptions as input for the mapping process that devises several heuristi

The association between birth position and obstetric anal sphincter injury (OASIS) in spontaneous vaginal deliveries is unclear.

This article is, first, an analysis of arguments that have been leveled against systematic empirical research in psychoanalysis. The arguments are basically two: It cannot uncover unobservable processes, and it cannot account for the uniqueness of the psychoanalytic dyad. Therefore, systematic empirical research is said to be incompatible with basic tenets of psychoanalysis. Both arguments are ref

The molecular mechanics/generalized Born surface area (MM/GBSA) method has been investigated with the aim of achieving a statistical precision of 1 kJ/mol for the results. We studied the binding of seven biotin analogues to avidin, taking advantage of the fact that the protein is a tetramer with four independent binding sites, which should give the same estimated binding affinities. We show that i

Background Autologous haematopoietic stem cell transplantation (HSCT) is a viable option for treatment of aggressive multiple sclerosis (MS). No randomised controlled trial has been performed, and thus, experiences from systematic and sustained follow-up of treated patients constitute important information about safety and efficacy. In this observational study, we describe the characteristics and

Purpose – This paper aims to develop a novel micro-ablation system to realise micrometric and well-defined hydrogel structures. To engineer a tissue it is necessary to evaluate several aspects, such as cell-cell and cell-substrate interactions, its micro-architecture and mechanical stimuli that act on it. For this reason, it is important to fabricate a substrate which presents a microtopology simi

We show that high harmonic generation driven by an intense near-infrared (IR) laser can be temporally controlled when an attosecond pulse train (APT) is used to ionize the generation medium, thereby replacing tunnel ionization as the first step in the well-known three-step model. New harmonics are formed when the ionization occurs at a well-defined time within the optical cycle of the IR field. Th

ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performed t

OBJECTIVE-Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed to characterize 19 such loci using detailed measures of insulin processing, secretion, and sensitivity to help elucidate their role in regulation of glucose control, insulin secretion and/or action. RESEARCH DESIGN AND METHODS-We investigated associations of loci identif

The modernisation of human civilisation demands sacrifices of other species for work, food, clothing, medical research, space exploration – and human self affirmation. To enable the asymmetrical relations, a hierarchical dualism between Man and Animal has been constructed and is maintained by a mechanism of continual differentiation. My aim in this article is to consider how literary fiction may t

To evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of hepatic function. Patients with advanced solid malignancies, acceptable bone marrow and renal function, and normal or impaired hepatic function, per NCI-ODWG criteria, were eligible. Initially patients received a single oral dose of 30 mg panobinostat for a 1-week pharmaco

Union density remains very high in Sweden. The significantly raised fees for union unemployment funds in January 2007 were followed by an unprecedented decline in the number of union members in modern Swedish history. In the course of two years union density dropped by 6 percentage points: from 77% in 2006 to 71% in 2008. As a result, the density of employers’ associations today is much higher tha

A measurement of elastic deeply virtual Compton scattering gamma*p --> gamma p using e(+) p and e(-) p collision data recorded with the HI detector at HERA is presented. The analysed data sample corresponds to an integrated luminosity of 306 pb(-1), almost equally shared between both beam charges. The cross section is measured as a function of the virtuality Q(2) of the exchanged photon and the ce

A small fraction of the halo field is made up of stars that share the light element (Z