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Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Wetland bird species have been declining in population size worldwide as climate warming and land-use change affect their suitable habitats. We used species distribution models (SDMs) to predict changes in range dynamics for 64 non-passerine wetland birds breeding in Europe, including range size, position of centroid, and margins. We fitted the SDMs with data collected for the first European Breed

Bacteria in the order 'Candidatus Brocadiales' within the phylum Planctomycetes (Planctomycetota) have the remarkable ability to perform anaerobic ammonium oxidation (anammox). Two families of anammox bacteria with different biogeographical distributions have been reported, marine Ca. Scalinduaceae and freshwater Ca. Brocadiaceae. Here we report evidence of three new species within a novel genus a

Människobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte melMänniskobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte mel

I detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som erI detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som er

Starch is the most abundant component in wheat flour, but has not traditionally been regarded as responsible for differences in quality between wheat varieties. In this chapter the role of starch in the baking process is described and examples on the role of starch during mixing, fermentation, and the oven step are given. The relevance of starch for baking performance is discussed, e.g., the setti

Nanoporous metals fabricated by dealloying have a unique bi-continuous, sponge-like porous structure with ultra-high surface area. The unique properties of these materials, especially nanoporous gold, have numerous potential applications in sensors and actuators and in energy-related applications such as catalytic materials, super-capacitors, and battery supports. The degree of porosity and size o

Summary: Microstructures from the millimeter- tonanometer scale have been studied and described in ametal nodule from the Vaca Muerta mesosiderite. Ourobservations are interpreted in the context of formationmechanisms.

Insomnia and sleep apnea represent the most prevalent sleep disorders worldwide. Incidences are discouraging, with perhaps less attention in some parts, and the complexity in the pathophysiologies of the two diseases pose a major challenge to clinicians and researchers. Mainstream therapeutic regimens are afflicted by adverse side effects, laborious, demanding enormous amounts of money, and are in

Inorganic lead is the most extensively studied environmental toxin. Today's humans have in the order of 100 times higher lead exposure, compared to prehistoric humans, mainly from food. The exposure was even higher during the 20th century, mainly due to lead addition to gasoline. Today, high exposures occur in many occupations, but also through, for example, contaminated drinking water, traditiona

With the aim of understanding how the International Criminal Court (ICC) affects peace processes, this article examines the Colombian peace and justice processes through the lens of friction. It investigates frictional encounters between the Colombian judicial system and the ICC, in order to reveal the tensions in this relationship. First, we disaggregate the concept of friction and propose three

We study the rheological response of dense suspensions of elliptical particles, with an aspect ratio equal to 3, under oscillatory shear flows and imposed pressure by numerical simulations. Like for the isotropic particles, we find that the oscillatory shear flows respect the Cox-Merz rule at large oscillatory strains but differ at low strains, with a lower viscosity than the steady shear and high

The principles of diversity and inclusion are valued across the higher education sector, but the ways in which these principles are translated into pedagogic practice are not always evident. Students who are first in their family to attend university continue to report barriers to full participation in university life. They are more likely to leave their studies early, and to achieve lower grades

Leading change in relation to assessment is a significant challenge; almost everyone in the university is a stakeholder and they may have strong and varied views about how assessment should be managed. A baseline review of assessment practices at a large, diverse, and complex university showed that the prevailing culture around assessment was equivocal and that people were fearful of large-scale c

The early withdrawal of students from healthcare education programmes, particularly nursing, is an international concern and, despite considerable investment, retention rates have remained stagnant. Here, a regional study of healthcare student retention is used as an example to frame the challenge of student attrition using a concept from policy development, wicked problem theory. This approach al

This chapter explores the role of assessment in global citizenship education (GCE). We will consider what can be assessed, and how teachers can design and manage appropriate assignment tasks in relation to normative assessment practices. The ways in which assessment might inform curriculum, behaviours, and engagement with GCE are considered in relation to institutional practices. The role of the a

University policies are increasingly developed with reference to students’ learning experiences, with a focus on the concept of the ‘student voice’. Yet the ‘student voice’ is difficult to define and emphasis is often placed on numerical performance indicators. A diverse student population has wide-ranging educational experiences, which may not be easily captured within the broad categories provid

This chapter examines the role and responsibilities of the individual academic developer and how these reflect the context of the engagement. It considers how different responses to the development context can be identified - not as a prescription designed to treat each individual case, but as a framework for evaluating the need and creating an environment for meeting it successfully. It will make

This paper reflects on the work done at a large UK university to redesign assessment procedures in a way that was intended to contribute to an improvement in assessment literacy for staff. Existing practice was reviewed and showed that changes in assessment processes were needed to make the organization of assessment more consistent and more transparent across the institution and to develop staff