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Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO)

Background and purpose: There is an urgent need to improve patient-selection to surgical treatment in advanced ovarian cancer as our results showed that cytoreductive surgery was without effect or even detrimental in a yet unknown subgroup of women. With an ageing population, 30% of women with advanced ovarian cancer in Sweden are >75 years. Nevertheless, there are no recommendations on patient-se

Increased frontocortical microvascular raspberry density in frontotemporal lobar degeneration compared to Lewy body disease and control cases: a neuropathological study

Background: Brain raspberries are histologically defined microvascular entities that are highly prevalent in the neocortex. Increased cortical raspberry density occurs in vascular dementia, but also with advancing age. Here, we examined the raspberry density in two neurodegenerative diseases, wherein vascular alterations distinct from conventional vascular risk factors have been indicated: frontot

Visualization of unsteady combustion of single aluminum droplets: coalescence, eruption and fragmentation

Detailed characterization of the unsteady combustion behaviors of individual aluminum (Al) droplets is scarce, due to the experimental challenges in resolving the transient phenomena at the micrometer scale. In this work, we spatiotemporally elucidate the complex interplay, including droplet coalescence, eruption, and fragmentation, of individually burning Al droplets and alumina (Al2O3) products,

A CO2–Δ14CO2 inversion setup for estimating European fossil CO2 emissions

Independent estimation and verification of fossil CO2 emissions on a regional and national scale are crucial for evaluating the fossil CO2 emissions and reductions reported by countries as part of their nationally determined contributions (NDCs). Top-down methods, such as the assimilation of in situ and satellite observations of different tracers (e.g., CO2, CO, Δ14CO2, XCO2), have been increasing

Recession experiences during early adulthood shape prosocial attitudes later in life

This paper explores whether the experience of a recession during early adulthood shapes individuals’ prosocial attitudes. The analysis uses survey responses to experimentally validated questions that measure prosocial attitudes for approximately 64,000 respondents in 74 countries. The identification approach exploits variation in recession experiences across 75 different birth cohorts. We find tha

Introduction

In this introduction, we explain how the chapters in this volume give support to the idea that different accounts of active cognition in the history of philosophy directly or indirectly respond to Aristotle’s account of cognition in his De anima.

Boethius of Dacia (1270s) and Radulphus Brito (1290s) on the Universal Sign ‘Every’

In this article I present the analysis of the syncategorematic term ‘omnis’ in the commentaries on the Topics by the Parisian masters of Arts Boethius of Dacia and Radulphus Brito. I shall focus on the different relations between subject, predicate and particular instances that obtain in universally quantified statements, and in particular on the relations that obtain in universally quantified sta

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The question 'whether an utterance (word/term/name) loses its signification with the destruction of things (i.e. things signified)' is raised as a question about the truth-value of assertions with an empty term as a subject, namely as a sub-problem of the sophism 'Whether "omnis homo de necessitate est animal" is true when no man exists (=OHNEA)'. In this paper, I shall introduce the discussions a

Martinus Dacus and Boethius Dacus on the signification of terms and the truth-value of assertions

The article intends to show: a) that the modist Martin of Dacia sides with the traditional reading of the first chapter of Aristotle's De interpretatione that we find in masters of arts from the first half of the thirteenth century; and b) that the modist Boethius of Dacia is one of the first thirteenth-century scholars to depart from this reading. In fact, Boethius presents us with an account of

Pragmatics in Peter John Olivi's account of signification of common names

The aim of this paper is to present a reconstruction of Olivi's account of signification of common names and to highlight certain intrusion of pragmatics into this account. The paper deals with the question of how certain facts, other than original imposition, may be relevant to determine the semantical content of an utterance, and not with the question of how we perform actions by means of uttera

Reading the signs : on inferential semiotics and market imagination

The paper concerns a historical shift in the semiotic interpretation of financial data and how this shaped the imagination of the market. The investigation centres on the emergence of two systems of financial foresight, technical and fundamental analysis. It is demonstrated how both systems were synthesised around the codification of certain pieces of data as semiotic windows to the future which t