In vivo cortical glutathione response to oral fumarate therapy in relapsing-remitting multiple sclerosis : A single-arm open-label phase IV trial using 7-Tesla 1H MRS
BACKGROUND: This is an open-label, single-arm, single-center pilot study using 7-Tesla in vivo proton magnetic resonance spectroscopy (1H MRS) to measure brain cortical glutathione concentration at baseline before and during the use of oral fumarates as a disease-modifying therapy for multiple sclerosis. The primary endpoint of this research was the change in prefrontal cortex glutathione concentr