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For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD), caused by mutations in GBA. In adult patients, the milder form presents with hepatomegaly, splenomegaly and occasional lung and bone disease; this is managed, symptomatically, by enzyme re
Photoinduced electronic and structural changes of a hydrogen-generating supramolecular RuPt photocatalyst are studied by a combination of time-resolved photoluminescence, optical transient absorption, and X-ray absorption spectroscopy. This work uses the element specificity of X-ray techniques to focus on the interplay between the photophysical and -chemical processes and the associated time scale
The large share of carbon emitted by energy-intensive industries in the extraction and processing of basic materials must be limited to decarbonise society and the economy. Ways in which the state can govern industrial decarbonisation and contributes to green state theory are explored by addressing a largely ignored issue: the green state’s industrial relations and its role in industrial governanc
Transition-metal complexes are used as photosensitizers1, in light-emitting diodes, for biosensing and in photocatalysis2. A key feature in these applications is excitation from the ground state to a charge-transfer state3,4; the long charge-transfer-state lifetimes typical for complexes of ruthenium5 and other precious metals are often essential to ensure high performance. There is much interest
A complete characterization of solar energy conversion devices and the processes underlying their function is a challenge, and require a multitude of different experimental methods. This chapter discusses investigations of molecular solar cells and solar fuels devices by time-resolved laser spectroscopic methods. These methods have established important concepts we now use for understanding the fu
The purpose of the article is to discuss the term ‘quality’ in relation to primary education in Tanzania, and to contextualize quality and identify the premises for obtaining quality in primary school education in rural and urban settings. To understand opinions about the quality of education and the current situation in primary schools, the author conducted interviews with teachers and focus grou
The multiconfiguration Dirac-Hartree-Fock theory is used to calculate the 3d9D3/22→2D5/2 transition energy for Co-like ions with Z=28-100. We investigate how electron correlation, frequency-independent and -dependent Breit interactions, as well as QED corrections vary along the sequence. The well-understood frequency-independent Breit contribution has the largest contribution for all ions. Among t
Control of nutrients, mainly nitrogen (N) and phosphorus (P), plays a significant role in preventing cyanobacterial blooms (harmful algal blooms (HABs)). This study aims at evaluating changes in the risk of the occurrence of cyanobacterial blooms and advancing the understanding of how nitrogen and phosphorus affect the growth of cyanobacteria in a eutrophic lake, Lake Vombsjön, in southern Sweden.
Background and purpose — Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors. Patients and methods — 340 subjects from the Osteoarthritis Initiative, a
Objective: The aim of this study was to clarify the association of scoliosis and windswept hips with immobility, lying position, and time in lying, in adults with cerebral palsy (CP). Methods: This cross-sectional study included 830 adults (469 males and 361 females) with a diagnosis of CP, 16–73 years, and classified at levels I–V according to the Gross Motor Function Classification System (GMFCS
Background: Today people can live a long time with a chronic cancer diagnosis, and it affects the entire family. Family members to patients in palliative care often have to leave valued occupations due to lack of time and energy, while new roles are forced upon them, potentially affecting their health. Objective: To explore occupational balance, needs and roles among family members to persons in p
This article presents an example of how the transnational production of memory is at work in a small Polish town that, prior to the Holocaust, was a “shtetl.” The author uses transnational optics to take an in-depth look at how local memories of Jews and the Holocaust are formed in this particular locality and discusses the effects of transnational mnemonic encounters. She highlights the multiscal
A Fe–Ti-rich garnet, clinopyroxene, and quartz eclogite sample from the 1.0 Ga Sveconorwegian orogen, SW Sweden, contains abundant quartz, rutile, and zircon in distinct micro-textural sites: garnet core, garnet rim, and matrix, constituting an ideal case for investigation of the behavior of Zr-in-rutile and Ti-in-quartz at high-pressure and temperature. A P–T path, peaking at 16.5–19 kbar and 850
Objectives: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. Data are, however, lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. Methods: A case-r
Electroactive polymers with time-dependent behavior are considered in the present paper by way of a new physics-based micromechanical model; such viscoelastic response is described by the internal evolution of the polymer network, providing a new viewpoint on the stress relaxation occurring in elastomers. The main peculiarity of such internally rearranging materials is their capacity to locally re
Objectives Poisoning is a frequent cause of admission to the emergency department (ED) and may involve drugs known to prolong the QT interval. This study aims to describe the prevalence of QTc prolongation among ED patients with suspected poisoning and to calculate the absolute and relative risk of mortality or cardiac arrest associated with a prolonged QTc interval. Methods We performed a registe
Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of t
The theory of quantum thermodynamics predicts fundamental bounds on work extraction from quantum states. As these bounds are derived in a very general and abstract setting, it is unclear how relevant they are in an experimental context, where control is typically limited. Here we address this question by showing that optimal work extraction is possible for a realistic engine. The latter consists o
