The SH3 domain of Bruton's tyrosine kinase (Btk) is preceded by the Tec homology (TH) region containing proline-rich sequences. We have studied a protein fragment containing both the Btk SH3 domain and the proline-rich sequences of the TH region (PRR-SH3). Intermolecular NMR cross-relaxation measurements, gel permeation chromatography profiles, titrations with proline-rich peptides, and N-15 NMR r

Abstract in UndeterminedIt has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes in animal models for RA resulted in the identification of

Popular Abstract in Swedish Cykeln som transportmedel har många fördelar för individ och samhälle. Det är ett mycket energisnålt transportmedel, det förorenar inte, bullrar inte, tar liten plats och ger dem som cyklar välbefinnande och motion. Om fler cyklade istället för att åka bil skulle detta medföra trevligare stadsmiljöer. Ökad cykling hade också kunnat bidra till en ökad folkhälsa. För närThis work presents an evaluation of bicycle lane effects on cyclist safety and the ability of bicycles to compete with car traffic. Thirteen Swedish urban streets were studied before and after bicycle lanes were introduced. Data was collected using video recordings, speed studies, road side questionnaires/interviews with cyclists/car drivers, conflict studies and accident analysis. Results showed

Sambandet mellan kunskapssyn, undervisning och examinationsformer på 20-poängskursen i statsvetenskap vid Lunds Universitet.

Cross-linking of polyvinylalcohol (PVA) by boronate-containing copolymer of N,N-dimethylacrylamide (DMAA, 1) was studied and compared to cross-linking of PVA by borate buffers in weakly alkaline solutions. The copolymer of M-w = 19,000 g mor(-1) containing 9 mol% N-acryloyl-m-aminophenylboronic acid (NAAPBA, 2) was prepared by free radical polymerization of the monomers, exhibiting copolymerizatio

Severe hypoglycemia was induced in rats by insulin. The brain was fixed in situ by perfusion after the spontaneous EEG had disappeared for 30 or 60 min or after recovery had been induced for 30 or 180 min by glucose injection. Samples from the cerebral cortex from the area corresponding to the previous metabolic studies were processed for electron microscopy. The light-microscopic finding of two d

An improved technique for direct vision chorionic biopsy that gives a clear view of the amniotic sac was developed. With this technique, used in 48 women prior to vacuum aspiration and in six cases for diagnosis (karyotyping or enzyme analysis), it was possible to obtain chorionic villi free from contamination by maternal tissue. It was also possible to pick out villi (rich in blood vessels and wi

Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we investigated and examined the fate and functional impact of bone marrow (BM) cells and embryonic stem cell (ES cell)-derived cardiomyocytes after transplantation into the infarcted mouse heart. This proved

The idea behind the service life model presented in this report was published in 1979. It has thereafter been described and developed in a number of reports and papers. The basis of the model is the observation that a well-defined critical, or maximum allowable, moisture content exists, above which the material is severely damaged by frost, and below which it is unharmed also when freezing is repe

Extreme degrees of obesity may occur in association with hypothalamic tumors, usually after surgical intervention. This phenomenon has been reported to occur in as many as 25-75% of children undergoing extensive surgical extirpation of craniopharyngiomas (Cranio). Because less is known about the auxology of children with Cranio with milder alterations in growth, we undertook a 3-yr longitudinal an

A thorough kinetic investigation of the ammoxidation of toluene over a V2O5 catalyst was carried out. Pressures of reactants were varied and rates for formation of benzonitrile and benzaldehyde were determined. Kinetic expressions completely describing experimental data were derived. A mechanisms is proposed on basis of both rate equations and other types of information published in the literature