AbstractBreast cancer (BC) is the most common cancer among women in Sweden and worldwide. Adjuvant endocrine therapies are effective, yet 20-30% patients experience disease relapse. Altered cholesterol metabolism is an emerging hallmark of breast cancer proliferation and endocrine therapy resistance. Studies have shown that the use of cholesterol-lowering medications (statins) reduces the risk of

Symmetry breaking and competition between electronic decay and nuclear dynamics are major factors determining whether the memory of the initial core-hole localisation in a molecule is retained long enough to affect fragmentation. We investigate the fate of core holes localised at different sites in the free 1,3 trans butadiene molecule by using synchrotron radiation to selectively excite core

Skogen är bäst på bild is an electroacoustic text-sound-composition work; it could also be considered a radiophonic work. This was the first work of text-sound composition I ever made, repurposing that more abstract genre here as a direct tool for finding memory and identity in the city. Although Stockholm’s history of text-ljud-komposition (text-sound-composition) is something I have engaged with

Under stjärnvalvets drömmar is a 19-minute, MIDI-driven composition for the Skandia theater organ, a 1926 Wurlitzer Unit Orchestra instrument that was refurbished and given a new home in the Reaktorhallen (The Reactor Hall, or “R1”) over the entire year of 2021. R1 is a huge, cavernous former nuclear reactor hall, several stories underground, hewn out of solid rock. The work is a collection of con

Ghost Installation Kafferepet is one of several "Ghost Installation" compositions in the project. Using small, consumer grade speakers and looping sound collage files, these sound installation compositions are placed in multichannel arrays into the sites they address.Ghost Installation: Kafferepet was installed outside the former site of the Kafferepet konditori (traditional Swedish coffee house),

I was asked to make this installation on the occasion of Cyklopen’s 5th anniversary celebration in their new building. Cyklopen is an “anarchist cultural house” in the Högdalen neighborhood, a suburb in the south of Stockholm. There was to be a great deal of loud music, crowds, presentations and general festivities, so I decided to make an oasis in the library, where some artworks were hanging. Lo

Ghost Installation: Sparvkvarteren was part of the same evening that Deuterium: Virkesvägen was composed for. It was made with a single, combined recording of sparrows from Solna, Tensta and Hammarby, two clips of synthesizer material, and two recordings of the construction machinery closing in on Virkesvägen 3, recorded the same week we made our event in the Coyote Collective’s exhibition, Pionee

In January of 2022, I made an installation event at Rönnells. I set larger speakers up on the balcony, and played three of the large-scale multi-channel compositions from this project– Skogen är bäst på bild, Vädersolsmodernitet and Vart ska dom ta vägen nu?–at a very much lowered volume. I made them hoping they could function both as concert pieces and as installations. The event at Rönnels prove

The garden at the Moderna Museet is a garden for a future – even a post-future! – which had already passed into history when I arrived in 2011. I spent much of that summer contemplating this paradox through the lens of the presence and resonating echoes of Frukost i den Gröna and Paradiset. Even more, the colorful story of the Bucky Dome which had been erected in the garden illuminated the recentl

Tropical forests contribute a major sink for anthropogenic carbon emissions essential to slowing down the buildup of atmospheric CO2 and buffering climate change impacts. However, the response of tropical forests to more frequent weather extremes and long-recovery disturbances like fires remains uncertain. Analyses of field data and ecological theory raise concerns about the possibility of the Ama

OBJECTIVE: Access to effective treatments for adolescents with depression needs to improve. Few studies have evaluated behavioural activation (BA) for adolescent depression, and none remotely delivered BA. This study explored the feasibility and acceptability of therapist-guided and self-guided internet-delivered BA (I-BA) in preparation for a future randomised controlled trial (RCT). DESIGN: A si

The simplest and most natural definition of the term ‘conspiracy theory’ leads us to the conclusion that we are all conspiracy theorists. Yet, I claim that most of us would not self-identify as such. In this paper I call this the problem of self-identification. Since virtually everyone emerges as a conspiracy theorist, the term is essentially theoretically fruitless. It would be like defining inte

Calcium isotopes (δ44/40Ca) are particularly useful in palaeo-environmental studies due to the key role of carbonate minerals in continental weathering and their formation in seawater. The calcium isotope ratio can provide hints on past changes in the calcium fluxes, environmental shifts, ecological factors and alternatively diagenesis of carbonate rocks. The investigation of the Late Triassic cal

Objective: Priority areas for emergency care research are emerging and becoming ever more important. The objectives of this scoping review were to (1) provide a comprehensive overview of published emergency care priority-setting studies by collating and comparing priority-setting methodology and (2) describe the resulting research priorities identified. Methods: The Joanna Briggs Institute methodo

Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer an

Background: Supervisors play a key part as role models and supporting the learning during residents’ post-graduate medical education, but sometimes lack sufficient pedagogic training and are challenged by high demands in today’s healthcare. The aim of this study was to describe the strengths and areas for improvement identified in the supervision process by residents and supervisors in post-gradua

Treatment of melanoma with a BRAF inhibitor (BRAFi) frequently initiates development of BRAFi resistance, leading to increased tumor progression and metastasis. Previously, we showed that combined inhibition of elevated WNT5A and IL-6 signaling reduced the invasion and migration of BRAFi-resistant (BRAFi-R) melanoma cells. However, the use of a combined approach per se and the need for high inhibi