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Smart cities, knowledge generation and the enduring pursuit of urban innovation
2-loop short-distance constraints for the g − 2 HLbL
The recent experimental measurement of the muon g−2 at Fermilab National Laboratory, at a 4.2σ tension with the Standard Model prediction, highlights the need for further improvements on the theoretical uncertainties associated to the hadronic sector. In the framework of the operator product expansion in the presence of a background feld, the short-distance behaviour of the hadronic light-by-light
Decision support tool to mitigate ship-induced erosion in non-uniform, sheltered coastal fairways
The negative impact of maritime traffic in terms of shore erosion in sheltered coastal fairways can be mitigated by sustainable fairway management. Mitigation measures include regulating the ship traffic in terms of speed, routes, or size of ships, but can also involve erosion protection along a fairway. For effective shoreline management of a fairway, it is essential to predict ship waves, to ide
The record of early Silurian climate changes from South China and Baltica based on integrated conodont biostratigraphy and isotope chemostratigraphy
New conodont and stable isotope data are presented from the classical Baizitian section in the Yanbian County of Sichuan Province, South China. The Telychian to Sheinwoodian strata were sampled and studied for carbon isotope stratigraphy and conodont biostratigraphy. The paired δ13Ccarb and δ13Corg data reveal a pronounced positive excursion, the Manitowoc carbon isotope excursion (Manitowoc CIE,
Water and productivity accounting using WA+ framework for sustainable water resources management : Case study of northwestern Iran
An exhaustive evaluation of water resources is a prerequisite for evidence-informed planning and implementing sustainable management strategies. However, the lack of sufficient information on water supply and consumption, alongside the technical limitations on comprehensive accounting for inter-relations and interactions between the subsystems, has resulted in decisions with often long-lasting out
Postoperative speech impairment and cranial nerve deficits after secondary surgery of posterior fossa tumours in childhood : a prospective European multicentre study
Purpose: Brain tumours constitute 25% of childhood neoplasms, and half of them are in the posterior fossa. Surgery is a fundamental component of therapy, because gross total resection is associated with a higher progression-free survival. Patients with residual tumour, progression of residual tumour or disease recurrence commonly require secondary surgery. We prospectively investigated the risk of
Comparative analysis of planted and unplanted controls for assessment of rhizosphere priming effect
The rhizosphere priming effect (RPE) is increasingly being considered to be an important regulator of soil organic matter (SOM) decomposition and nutrient turnover, with potential importance for the global CO2 budget. As a result, studies on the RPE have rapidly increased in number over the last few years. Most of these experiments have been performed using unplanted soil as the control, which cou
Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period o
Short-lived species move uphill faster under climate change
Climate change is pushing species ranges and abundances towards the poles and mountain tops. Although many studies have documented local altitudinal shifts, knowledge of general patterns at a large spatial scale, such as a whole mountain range, is scarce. From a conservation perspective, studying altitudinal shifts in wildlife is relevant because mountain regions often represent biodiversity hotsp
Managing Marine Mammals and Fisheries : A Calibrated Programming Model for the Seal-Fishery Interaction in Sweden
This paper develops a model based on the concept of Positive Mathematical Programming (PMP) that is useful for ex-ante analyses of how policy measures affect commercial fisheries. PMP models are frequently used in agriculture, but rarely for analyzing fisheries. Fisheries often face a large set of constraints such as effort regulations and catch quotas of which some might be binding and others not
Mental health, sleep and pain in elite Para athletes and the association with injury and illness ‐ a prospective study
IntroductionThe interest in Para athletes’ health continues to increase. Still, there are few studies that have evaluated health parameters beyond injury and illness in this athlete population.ObjectiveTo assess: i) the weekly proportion of elite Para athletes reporting anxiety/depression, low sleep levels (≤7 hours) and pain over 52 weeks and; ii) and to explore whether these health parameters ar
Gender preference gaps and voting for redistribution
There is substantial evidence that women tend to support different policies and political candidates than men. Many studies also document gender differences in a variety of important preference dimensions, such as risk-taking, competition and pro-sociality. However, the degree to which differential voting by men and women is related to these gaps in more basic preferences requires an improved unde
Alarm Technologies to Wake Sleeping People Who are Deaf or Hard of Hearing
Traditional fire alarms emit a high-frequency sound to alert the occupants of an imminent threat, which may be less appropriate for people who are deaf or hard of hearing. To address this issue, the scientific literature concerning alternative alarm technologies has been reviewed to evaluate their effectiveness in awakening people who are deaf or hard of hearing. The results show that low-frequenc
Tax presumptions in the Netherlands
Experimental analyses of step extent and contact buffer in pedestrian dynamics
This study aims to quantify and develop a deeper understanding of the parameters that underpin the development of a new, predictive, microscopic model of pedestrian movement with the potential to accurately reflect the complexity of flow dynamics now and into the future. It presents the results and analyses of two single file experiments designed to quantify the physical space taken up by the exte
Bee and non-bee pollinator importance for local food security
Pollinators are critical for food security; however, their contribution to the pollination of locally important crops is still unclear, especially for non-bee pollinators. We reviewed the diversity, conservation status, and role of bee and non-bee pollinators in 83 different crops described either as important for the global food market or of local importance. Bees are the most commonly recorded c
AXL Knock-Out in SNU475 Hepatocellular Carcinoma Cells Provides Evidence for Lethal Effect Associated with G2 Arrest and Polyploidization
AXL, a member of the TAM family, is a promising therapeutic target due to its elevated expression in advanced hepatocellular carcinoma (HCC), particularly in association with acquired drug resistance. Previously, RNA interference was used to study its role in cancer, and several phenotypic changes, including attenuated cell proliferation and decreased migration and invasion, have been reported. Th
TAp73β Can Promote Hepatocellular Carcinoma Dedifferentiation
Hepatocyte dedifferentiation is a major source of hepatocellular carcinoma (HCC), but its mechanisms are unknown. We explored the p73 expression in HCC tumors and studied the effects of transcriptionally active p73β (TAp73β) in HCC cells. Expression profiles of p73 and patient clinical data were collected from the Genomic Data Commons (GDC) data portal and the TSVdb database, respectively. Global
Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer
Selective autophagy of the endoplasmic reticulum (ER), namely ER-phagy, is mediated by ER-localized receptors, which are recognized and sequestered by GABARAP/LC3B-decorated phagophores and transferred to lysosomes for degradation. Being one such receptor, FAM134B plays critical roles in cellular processes such as protein quality control and neuronal survival. FAM134B has also been associated with