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Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to re
Living with a life-limiting cancer illness can entail a turmoil of feelings such as constant fear of loss, suffering and dying. Because patients live longer with life-limiting illness, there is a need for enhanced understanding of how people make sense of and cope with the complicated aspects that this life situation brings on. In this article, we explore how bloggers with advanced cancer use meta
Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that ha
This chapter explores the themes of sin and punishment through the lens of a theodicy that the authors and redactors of Isaiah offer to justifyYHWH’s actions and to instruct the Israelites to stay loyal to him. The three parts of Isaiah agree that the exile wasYHWH’s punishment for the Israelites’ rebellion demonstrated through social injustice and idolatry. However, because of the different hist
Water is vital to all life on earth, but its management is becoming more difficult owing to the behavior of water in nature such as water dynamics, water movements, and different forms of water in nature. In addition, population growth, the impact of climate change, and the inappropriate use of water resources add more complexity to water resource management. The integration of natural sciences ne
There is a growing call for comparative analyses of forest governance to facilitate knowledge exchange for the sustainable management of Nordic forest systems, addressing the needs of societal stakeholders in enhancing both the quality and quantity of forest resources. This study traces the development of nation-wide policy instruments implemented in four Nordic countries; Finland, Sweden, Norway
Local genetic correlation analysis is an important tool for identifying genetic loci with shared biology across traits. Recently, Border et al. have shown that the results of these analyses are confounded by cross-trait assortative mating (xAM), leading to many false-positive findings. Here, we describe LAVA-Knock, a local genetic correlation method that builds off an existing genetic correlation
Fano resonances are ubiquitous phenomena appearing in many fields of physics, e.g., atomic or molecular photoionization, or electron transport in quantum dots. Recently, attosecond interferometric techniques have been used to measure the amplitude and phase of photoelectron wave packets close to Fano resonances in argon and helium, allowing for the retrieval of the temporal dynamics of the photoio
Rapid urbanization can change local climate by increasing land surface temperature (LST), particularly in metropolitan regions. This study uses two decades of remote sensing data to investigate how urbanization-induced changes in land use/land cover (LULC) affect LST in the Beijing Region, China. By focusing on the key issue of LST and its contributing variables through buffer zones, we determined
We present smoothed particle hydrodynamic models of the interactions in the compact galaxy group, Stephan’s Quintet. This work is extension of the earlier collisionless N-body simulations of Renaud et al. in which the large-scale stellar morphology of the group was modelled with a series of galaxy–galaxy interactions in the simulations. Including thermohydrodynamic effects in this work, we further
The evolution of compact groups of galaxies may represent one of the few places in the nearby universe in which massive galaxies are being forged through a complex set of processes involving tidal interaction, ram-pressure stripping, and perhaps finally "dry mergers" of galaxies stripped of their cool gas. Using collisionless N-body simulations, we propose a possible scenario for the formation of
In modern building construction, where light weight structures are preferred for cost reasons, the sound transmission is often a problem to be considered carefully, hence the many studies addressing this issue. Various modal methods are frequently used to investigate the vibration pattern of light weight building structures in the low frequency range. The experimental determination of time average
Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 7
Purpose: Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to explore plasma extracellular vesicle (plEV) immunoprofiling as a tool for noninvasive diagnosis of glioma.Experimental Design: PlEV isolation and analysis were optimized using advanced mass spectrometry, nanoparticle tracking analysis,
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nest
Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discover
The presence of unobserved heterogeneity and its likely detrimental effect on inference has recently motivated the use of factor-augmented panel regression models. The workhorse of this literature is based on first estimating the unknown factors using the cross-section averages of the observables, and then applying ordinary least squares conditional on the first-step factor estimates. This is the
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help
