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INTRODUCTION: A subset of amyloid beta (Aβ)-positive Alzheimer's disease (AD) patients is tau-positron emission tomography (PET) negative. We aimed to characterize this subgroup using [18F]flortaucipir PET visual read (VR), as this is important for prognosis and selection for therapies. METHODS: Aβ-positive VR tau-PET-negative AD dementia patients (AD A+T−) were compared to tau-PET-positive AD pat
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To evaluate the benefits and harms of using NGS techniques compared to conventional newborn screening alone for pre-symptomatic identification of genetic diseases in newborns. Secondary objectives: to explore equity and ethical issues in the application of the new techniques, to inform healthcare d
Objective Giant cell arteritis (GCA) is a systemic disease with variable vascular involvement. The objective was to investigate predictors of time-dependent large-vessel involvement (LVI) in a population-based cohort of patients with GCA. Methods GCA patients with positive temporal artery biopsies (TAB) between 1997- 2010 were identified through a regional pathology register. A structured review o
Background: Surgical site infection (SSI) following orthopedic surgery is a complication associated with morbidity and economic burden. Transmission of airborne bacteria that settle into surgical wounds constitutes a risk factor for SSIs. However, monitoring microbial contamination inside operating rooms with conventional methods is resource and time-consuming. Aim: This study aimed to assess corr
Around one-fourth of the global population lacks access to clean fuels and technologies for cooking, most of them living in low- and middle-income countries. Reliance on rudimentary and inefficient biomass cookstoves results in high pollutant concentrations that adversely affect the health of those exposed to indoor air pollution, the environment, and the climate. In this study, we systematically
Background: Little is known regarding treatment with cangrelor during percutaneous coronary intervention (PCI) in patients with myocardial infarction complicated by cardiogenic shock or cardiac arrest. Objectives: The aim of this study was to investigate the effects of such cangrelor treatment during PCI in patients with myocardial infarction complicated by cardiogenic shock or cardiac arrest. Met
A common type of inhalation medicine uses a dry powder formulation where the active pharmaceutical ingredient (API) is attached on the surface of carrier particles, often in combination with additional components. The spatial distribution of the API on the carrier particle is critical for the release into the lungs and thus for the efficacy of the drug. In this work, we use ToF-SIMS imaging in com
Background: Concerns about the cardiovascular safety of medications used for the treatment of attention-deficit hyperactivity disorder (ADHD) remain. We aimed to compare the effects of pharmacological treatments for ADHD on haemodynamic values and electrocardiogram (ECG) parameters in children, adolescents, and adults. Methods: For this systematic review and network meta-analysis, we searched 12 e
Introduction: The rate of vaginal hysterectomies is declining globally. We investigated surgical techniques, outcomes, and costs in a large national cohort of benign hysterectomies with prerequisites for vaginal surgery. Material and Methods: A retrospective register-based cohort study with benign hysterectomies in the Swedish GynOp registry 2014–2023 (n = 17 804). Inclusion criteria were non-prol
From the end of the twelfth to the fourteenth century, a second wave of towns emerged along the coasts and estuaries of the south Baltic Sea area. During this period, urban communities acquired a high degree of independence. Extensive changes to house building accompanied the development. Timber-framing and masonry emerged as new constructions and became the dominant forms of architecture. The art
This paper investigates distribution of decision rights and responsibilities between boards of directors and CEOs with a particular focus on allocation of residual control rights. In the studied firms, the board reserves residual control rights, stating that all major decisions are to reach the board. However, the CEO is authorized to make decisions on urgent matters if the board cannot be heard w
Prediction of incident macrovascular events (iMEs) in individuals with type 2 diabetes (T2D) remains suboptimal. We aim to discover blood-based epigenetic biomarkers predicting iMEs in 752 newly diagnosed individuals with T2D, among whom 102 developed iMEs during follow-up. 461 DNA methylation sites, e.g., near ARID3A, GATA5, HDAC4, IRS2, and TMEM51, associate with iMEs. Using cross-validation, a
During a series of writing workshops at a shelter for young homeless people in Copenhagen, I examined to what extent the literary practice of student-driven imitation with its emphasis on self-governance and a dialogical approach can engage marginalized learners in reading and writing. I found that studentdriven imitation had the potential to engage different kinds of writers and that they adopted
Quintilian’s notion of imitation is often acclaimed for its focus on invention and appropriateness and for highlighting attunement to individual talent. Yet these aspects tend to be somewhat neglected in the practice of imitation as shaped by the classical rhetorical tradition, which primarily focuses on imitation exercises for beginners. This essay accentuates Quintilian’s chapter on imitation, w
Genre pedagogy is widely proliferated in Scandinaviaand shares a number of features with the rhetorical tradition ofimitation. The strengths and weaknesses of the two approachesare quite similar and both can be criticized for being focused onskills and reproduction rather than on bildungand change. Thisarticle describes the aims and values of each approach anddiscusses them in the light of a case
Ifølge nyere undersøgelser af udbredte læremidler inden for skandinaviske modersmålsfag på grundskole-og gymnasieniveau behandles sagprosa og ikke mindst sagprosatekstens indhold og situation stedmoderligt. Derfor undersøger jeg i denne artikel gennem den eksemplariske metode Isokrates’ og dansklæreren Lauras tilgange til og intentioner med især brugen af eksempeltekster i undervisning. Ved at udf
