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PURPOSE: Cisplatin-based combination chemotherapy (CHT) is standard of care in metastatic urothelial cancer (mUC); however, no predictive molecular biomarkers are available for clinical use. The aim of this study was to investigate the impact of molecular subtypes in relation to treatment response and survival in patients with mUC treated with first-line CHT.PATIENTS AND METHODS: Molecular subtype

A geologically rapid Neoproterozoic oxygenation event is commonly linked to the appearance of marine animal groups in the fossil record. However, there is still debate about what evidence from the sedimentary geochemical record—if any—provides strong support for a persistent shift in surface oxygen immediately preceding the rise of animals. We present statistical learning analyses of a large datas

Inborn errors of metabolism (IEMs) are traditionally the domain of pediatricians and internists for metabolic diseases. In general, neurologists only become involved when these disorders are complicated by neurologic symptoms such as seizures, developmental delay, or motor problems. However, in recent years and mainly due to the successes of next-generation sequencing, the number of IEMs primarily

The research presented here explores the nuances of data collection and sharing via digital platforms in everyday CrossFit coaching practice. There is a growing body of work on data and digital platforms in CrossFit, though currently there is a lack of research on the role of coaches in these processes. Empirically grounding the digital fitness practices of CrossFit coaching is essential for our u

Site specific exhibition (photographs) at Pumphuset Borstahusens Konstförening, Landskrona

HIP 41378 d is a long-period planet that has only been observed to transit twice, three years apart, with K2. According to stability considerations and a partial detection of the Rossiter- McLaughlin effect, Pd = 278.36 d has been determined to be the most likely orbital period. We targeted HIP 41378 d with CHEOPS at the predicted transit timing based on Pd = 278.36 d, but the observations show no

Context. The TOI-421 planetary system contains two sub-Neptune-type planets (Pb ~ 5.2 days, Teqb ~ 900 K, and Pc ~ 16.1 days, Teq,c ~ 650 K) and is a prime target to study the formation and evolution of planets and their atmospheres. The inner planet is especially interesting as the existence of a hydrogen-dominated atmosphere at its orbital separation cannot be explained by current formation mode

The decays Λb0→Λc +D¯(∗)0K- and Λb0→Λc+Ds∗- are observed for the first time, in proton-proton collision data at s=13TeV, corresponding to an integrated luminosity of 5.4fb-1 collected with the LHCb detector. Their ratios of branching fractions with respect to the Λb 0→Λc +Ds - mode are measured to be (Formula presented.) where the first uncertainties are statistical, the second systematic, and the

Groupexhibition. Philip Dufva, Maria Hedlund och Eva Löfdahl.6 juli 2024–6 oktober 2024Jag betraktar allt som passerar mina ögon och testar det mot ett behov”.Citatet ovan, liksom utställningens titel, är hämtat från Eva Löfdahl – en konstnär som arbetar i många olika material och tekniker, alltid med det specifika behovet hos detta speciella verk som utgångspunkt – snarare än en färdig idé, ett u

IMPORTANCE: Over the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. Yet, in Europe, none of the countries have reported any significant decline in melanoma incidence for any age group.OBJECTIVE: To assess melanoma incidence and